| # | Title | Journal | Year | Citations |
|---|
| 1 | Multiattribute and Single-Attribute Utility Functions for the Health Utilities Index Mark 3 System | Medical Care | 2002 | 1,114 |
| 2 | A meta-analysis of the association between adherence to drug therapy and mortality | BMJ: British Medical Journal | 2006 | 1,027 |
| 3 | Amphiphilic block copolymers for drug delivery | Journal of Pharmaceutical Sciences | 2003 | 943 |
| 4 | Solute Diffusion within Hydrogels. Mechanisms and Models | Macromolecules | 1998 | 798 |
| 5 | Block copolymer micelles as long-circulating drug vehicles | Advanced Drug Delivery Reviews | 1995 | 725 |
| 6 | Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery | Advanced Drug Delivery Reviews | 2002 | 724 |
| 7 | Biodegradable injectable in situ forming drug delivery systems | Journal of Controlled Release | 2002 | 632 |
| 8 | Adverse Effects of Nonsteroidal Antiinflammatory Drugs: An Update of Gastrointestinal, Cardiovascular and Renal Complications | Journal of Pharmacy and Pharmaceutical Sciences | 2013 | 528 |
| 9 | Rapid and accurate calculation of protein 1H, 13C and 15N chemical shifts | Journal of Biomolecular NMR | 2003 | 492 |
| 10 | Celiac disease: Prevalence, diagnosis, pathogenesis and treatment | World Journal of Gastroenterology | 2012 | 491 |
| 11 | Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin | ACS Nano | 2011 | 396 |
| 12 | Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls | Journal of Pharmaceutical Sciences | 1989 | 376 |
| 13 | Targeted delivery of nanoparticles for the treatment of lung diseases | Advanced Drug Delivery Reviews | 2008 | 375 |
| 14 | Polymeric micelles for drug delivery | Expert Opinion on Drug Delivery | 2006 | 369 |
| 15 | Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges | Expert Opinion on Drug Delivery | 2014 | 357 |
| 16 | Use of Chemical Shifts in Macromolecular Structure Determination | Methods in Enzymology | 2002 | 320 |
| 17 | P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives | Current Cancer Drug Targets | 2013 | 320 |
| 18 | Clinical Pharmacokinetics of Diclofenac | Clinical Pharmacokinetics | 1997 | 315 |
| 19 | Block copolymer micelles for drug delivery: loading and release of doxorubicin | Journal of Controlled Release | 1997 | 302 |
| 20 | Buccal mucosa as a route for systemic drug delivery: a review | Journal of Pharmacy and Pharmaceutical Sciences | 1998 | 265 |
| 21 | An approach to drug induced delirium in the elderly | Postgraduate Medical Journal | 2004 | 262 |
| 22 | Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations | Advanced Drug Delivery Reviews | 2011 | 257 |
| 23 | Encapsulation of plasmid DNA in biodegradable poly(d,l-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery | Journal of Controlled Release | 1999 | 245 |
| 24 | Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung | International Journal of Pharmaceutics | 2004 | 245 |
| 25 | Synthesis and antifungal activity of coumarins and angular furanocoumarins | Bioorganic and Medicinal Chemistry | 1999 | 244 |
| 26 | Molecular dynamics-driven drug discovery: leaping forward with confidence | Drug Discovery Today | 2017 | 243 |
| 27 | Comparison of the EQ-5D and SF-12 Health Surveys in a General Population Survey in Alberta, Canada | Medical Care | 2000 | 240 |
| 28 | Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery | Journal of Controlled Release | 2011 | 238 |
| 29 | Characterization of poly(d,l-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells | Vaccine | 2004 | 227 |
| 30 | Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity | Vaccine | 2008 | 227 |
| 31 | Determinants of Function After Total Knee Arthroplasty | Physical Therapy | 2003 | 223 |
| 32 | Current perspectives in dissolution testing of conventional and novel dosage forms | International Journal of Pharmaceutics | 2007 | 218 |
| 33 | ‘Magic bullets’ for bone diseases: progress in rational design of bone-seeking medicinal agents | Chemical Society Reviews | 2007 | 214 |
| 34 | Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery | Nature Reviews Drug Discovery | 2008 | 209 |
| 35 | The Uniqueness of Albumin as a Carrier in Nanodrug Delivery | Molecular Pharmaceutics | 2021 | 209 |
| 36 | Design and Synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors: Replacement of Sulfonamide and Methylsulfonyl Pharmacophores by an Azido Bioisostere | Journal of Medicinal Chemistry | 2001 | 207 |
| 37 | [18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors | Nuclear Medicine and Biology | 2003 | 205 |
| 38 | Renal adverse effects of nonsteroidal anti-inflammatory drugs | Expert Opinion on Drug Safety | 2009 | 203 |
| 39 | Micelles of methoxy poly(ethylene oxide)-b-poly(ɛ-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A | Journal of Controlled Release | 2005 | 200 |
| 40 | Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study | Cmaj | 2006 | 186 |
| 41 | The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin | Biomaterials | 2010 | 185 |
| 42 | Mitochondrial Delivery of Doxorubicin via Triphenylphosphine Modification for Overcoming Drug Resistance in MDA-MB-435/DOX Cells | Molecular Pharmaceutics | 2014 | 185 |
| 43 | Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo | Journal of Biomedical Materials Research Part B | 2002 | 182 |
| 44 | Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery | Journal of Controlled Release | 2005 | 182 |
| 45 | Mortality risk among sulfonylureas: a systematic review and network meta-analysis | Lancet Diabetes and Endocrinology,the | 2015 | 180 |
| 46 | Clinical Pharmacokinetics of Ketoprofen and Its Enantiomers | Clinical Pharmacokinetics | 1990 | 178 |
| 47 | The CyberCell Database (CCDB): a comprehensive, self-updating, relational database to coordinate and facilitate in silico modeling of Escherichia coli | Nucleic Acids Research | 2004 | 178 |
| 48 | 1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling | Molecules | 2014 | 175 |
| 49 | Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function | Circulation Research | 2006 | 173 |
| 50 | Polymeric micelles for drug targeting | Journal of Drug Targeting | 2007 | 170 |
