| # | Title | Journal | Year | Citations |
|---|
| 1 | RoB 2: a revised tool for assessing risk of bias in randomised trials | BMJ: British Medical Journal | 2019 | 10,984 |
| 2 | Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study | Intensive Care Medicine | 2015 | 1,838 |
| 3 | Paracrine Factors of Mesenchymal Stem Cells Recruit Macrophages and Endothelial Lineage Cells and Enhance Wound Healing | PLoS ONE | 2008 | 1,350 |
| 4 | Microstructural maturation of the human brain from childhood to adulthood | NeuroImage | 2008 | 1,223 |
| 5 | Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways | Cancers | 2017 | 1,153 |
| 6 | A meta-analysis of the association between adherence to drug therapy and mortality | BMJ: British Medical Journal | 2006 | 1,027 |
| 7 | Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup | Nature Reviews Nephrology | 2017 | 946 |
| 8 | Cells of the adult human heart | Nature | 2020 | 852 |
| 9 | Kinase-targeted cancer therapies: progress, challenges and future directions | Molecular Cancer | 2018 | 796 |
| 10 | Global epidemiology and outcomes of acute kidney injury | Nature Reviews Nephrology | 2018 | 698 |
| 11 | Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin | Nature Medicine | 2013 | 674 |
| 12 | How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline | Trials | 2016 | 659 |
| 13 | Drinking Water Disinfection Byproducts (DBPs) and Human Health Effects: Multidisciplinary Challenges and Opportunities | Environmental Science & Technology | 2018 | 584 |
| 14 | Acute kidney injury—epidemiology, outcomes and economics | Nature Reviews Nephrology | 2014 | 564 |
| 15 | IOC consensus statement on relative energy deficiency in sport (RED-S): 2018 update | British Journal of Sports Medicine | 2018 | 518 |
| 16 | The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis | Intensive Care Medicine | 2017 | 510 |
| 17 | Acute kidney injury in sepsis | Intensive Care Medicine | 2017 | 490 |
| 18 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 19 | COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup | Nature Reviews Nephrology | 2020 | 466 |
| 20 | A microRNA-initiated DNAzyme motor operating in living cells | Nature Communications | 2017 | 448 |
| 21 | Breathing matters | Nature Reviews Neuroscience | 2018 | 446 |
| 22 | Coming together to define membrane contact sites | Nature Communications | 2019 | 435 |
| 23 | Cross-protective efficacy of HPV-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by non-vaccine oncogenic HPV types: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial | Lancet Oncology, The | 2012 | 432 |
| 24 | A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation* | Critical Care Medicine | 2013 | 423 |
| 25 | Stroke Risk Profile Predicts White Matter Hyperintensity Volume | Stroke | 2004 | 415 |
| 26 | Hazard Ratio in Clinical Trials | Antimicrobial Agents and Chemotherapy | 2004 | 406 |
| 27 | Rapid exchange of histone H1.1 on chromatin in living human cells | Nature | 2000 | 397 |
| 28 | Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity | Diabetes | 2007 | 395 |
| 29 | Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice | Diabetes | 2006 | 387 |
| 30 | Canadian 24-Hour Movement Guidelines for the Early Years (0–4 years): An Integration of Physical Activity, Sedentary Behaviour, and Sleep | BMC Public Health | 2017 | 382 |
| 31 | Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis | Nature Medicine | 2015 | 376 |
| 32 | Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM) | Biochimica Et Biophysica Acta - Molecular Cell Research | 2013 | 373 |
| 33 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 367 |
| 34 | Optimal Perioperative Care in Major Head and Neck Cancer Surgery With Free Flap Reconstruction | JAMA Otolaryngology - Head and Neck Surgery | 2017 | 351 |
| 35 | Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression | Experimental Neurology | 2007 | 348 |
| 36 | High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial | Intensive Care Medicine | 2013 | 347 |
| 37 | Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort | BMJ: British Medical Journal | 2011 | 343 |
| 38 | Eteplirsen in the treatment of Duchenne muscular dystrophy | Drug Design, Development and Therapy | 2017 | 334 |
| 39 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 40 | Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials | BMJ, The | 2021 | 322 |
| 41 | Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis | British Journal of Sports Medicine | 2018 | 318 |
| 42 | Diffusion tensor imaging of neurodevelopment in children and young adults | NeuroImage | 2005 | 313 |
| 43 | Saturation recovery single‐shot acquisition (SASHA) for myocardial T1 mapping | Magnetic Resonance in Medicine | 2014 | 307 |
| 44 | The role of neurotrophic factors in nerve regeneration | Neurosurgical Focus | 2009 | 303 |
| 45 | Molecular Diagnosis of COVID-19: Challenges and Research Needs | Analytical Chemistry | 2020 | 294 |
| 46 | Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review | BMJ: British Medical Journal | 2007 | 293 |
| 47 | Effectiveness of School Programs in Preventing Childhood Obesity: A Multilevel Comparison | American Journal of Public Health | 2005 | 292 |
| 48 | Cerebral Microbleeds | Stroke | 2004 | 287 |
| 49 | Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level | JAMA - Journal of the American Medical Association | 2018 | 286 |
| 50 | ErbB Receptors and Cancer | Methods in Molecular Biology | 2017 | 283 |
