| # | Title | Journal | Year | Citations |
|---|
| 1 | Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index | Nature Genetics | 2010 | 2,634 |
| 2 | Hundreds of variants clustered in genomic loci and biological pathways affect human height | Nature | 2010 | 1,789 |
| 3 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 4 | Benefits and limitations of genome-wide association studies | Nature Reviews Genetics | 2019 | 1,226 |
| 5 | Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial | Gastroenterology | 2015 | 1,161 |
| 6 | Impact of the patient population on the risk for heparin-induced thrombocytopenia | Blood | 2000 | 976 |
| 7 | Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits | Nature Genetics | 2018 | 924 |
| 8 | Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings | Journal of Thrombosis and Haemostasis | 2006 | 916 |
| 9 | Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE) | Lancet, The | 2000 | 866 |
| 10 | Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution | Nature Genetics | 2010 | 836 |
| 11 | Western blot: Technique, theory, and trouble shooting | North American Journal of Medical Sciences | 2012 | 832 |
| 12 | Immunological considerations for COVID-19 vaccine strategies | Nature Reviews Immunology | 2020 | 806 |
| 13 | Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction | Cell Host and Microbe | 2017 | 799 |
| 14 | The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis? | International Journal of Biochemistry and Cell Biology | 2008 | 781 |
| 15 | Subgroup-specific structural variation across 1,000 medulloblastoma genomes | Nature | 2012 | 761 |
| 16 | New loci associated with kidney function and chronic kidney disease | Nature Genetics | 2010 | 710 |
| 17 | Consensus guidelines for the detection of immunogenic cell death | OncoImmunology | 2014 | 686 |
| 18 | ICOS is essential for effective T-helper-cell responses | Nature | 2001 | 629 |
| 19 | Can extra protamine eliminate heparin rebound following cardiopulmonary bypass surgery? | Journal of Thoracic and Cardiovascular Surgery | 2004 | 624 |
| 20 | How cigarette smoke skews immune responses to promote infection, lung disease and cancer | Nature Reviews Immunology | 2009 | 552 |
| 21 | Cell encapsulation: Promise and progress | Nature Medicine | 2003 | 546 |
| 22 | Epigenomic alterations define lethal CIMP-positive ependymomas of infancy | Nature | 2014 | 521 |
| 23 | Going viral with cancer immunotherapy | Nature Reviews Cancer | 2014 | 500 |
| 24 | Aging, frailty and age-related diseases | Biogerontology | 2010 | 489 |
| 25 | Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation | PLoS Pathogens | 2010 | 488 |
| 26 | The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses | Nature Immunology | 2003 | 479 |
| 27 | The Dual Nature of Type I and Type II Interferons | Frontiers in Immunology | 2018 | 469 |
| 28 | American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia | Blood Advances | 2018 | 448 |
| 29 | Association of Genomic O Island 122 of Escherichia coli EDL 933 with Verocytotoxin-Producing Escherichia coli Seropathotypes That Are Linked to Epidemic and/or Serious Disease | Journal of Clinical Microbiology | 2003 | 444 |
| 30 | Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea | JAMA Internal Medicine | 2020 | 439 |
| 31 | Regulation of Transforming Growth Factor-β1–driven Lung Fibrosis by Galectin-3 | American Journal of Respiratory and Critical Care Medicine | 2012 | 425 |
| 32 | Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells | Cell | 2012 | 420 |
| 33 | Surgical Mask vs N95 Respirator for Preventing Influenza Among Health Care Workers | JAMA - Journal of the American Medical Association | 2009 | 414 |
| 34 | Detection of Respiratory Viruses by Molecular Methods | Clinical Microbiology Reviews | 2008 | 405 |
| 35 | Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma | Nature Genetics | 2009 | 391 |
| 36 | Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation | Gut | 2007 | 387 |
| 37 | Vitamin D, cognition, and dementia | Neurology | 2012 | 384 |
| 38 | Ly6ChiMonocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis | American Journal of Respiratory and Critical Care Medicine | 2011 | 383 |
| 39 | From big data analysis to personalized medicine for all: challenges and opportunities | BMC Medical Genomics | 2015 | 379 |
| 40 | II. Stress and intestinal barrier function | American Journal of Physiology - Renal Physiology | 2001 | 372 |
| 41 | The unique characteristics of COVID-19 coagulopathy | Critical Care | 2020 | 366 |
| 42 | Bats and Coronaviruses | Viruses | 2019 | 357 |
| 43 | Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis | Cell | 2000 | 356 |
| 44 | Investigating Intestinal Inflammation in DSS-induced Model of IBD | Journal of Visualized Experiments | 2012 | 354 |
| 45 | Smad3 Null Mice Develop Airspace Enlargement and Are Resistant to TGF-β-Mediated Pulmonary Fibrosis | Journal of Immunology | 2004 | 349 |
| 46 | History, challenges and perspectives of cell microencapsulation | Trends in Biotechnology | 2004 | 333 |
| 47 | Interactions Between the Immune System and Cancer: A Brief Review of Non-spatial Mathematical Models | Bulletin of Mathematical Biology | 2011 | 330 |
| 48 | Trans-ethnic association study of blood pressure determinants in over 750,000 individuals | Nature Genetics | 2019 | 328 |
| 49 | Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine | Clinical Chemistry | 2018 | 327 |
| 50 | Chronic stress induces mast cell–dependent bacterial adherence and initiates mucosal inflammation in rat intestine | Gastroenterology | 2002 | 326 |
