| # | Title | Journal | Year | Citations |
|---|
| 1 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study | Lancet, The | 2001 | 2,914 |
| 2 | Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease | New England Journal of Medicine | 2006 | 1,536 |
| 3 | Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients | Lancet, The | 2000 | 1,398 |
| 4 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 5 | Interventions on Prevention of Postoperative Atrial Fibrillation in Patients Undergoing Heart Surgery | Circulation | 2002 | 442 |
| 6 | Overcoming the limitations of current meta-analysis of randomised controlled trials | Lancet, The | 1998 | 415 |
| 7 | Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction11Drs. Mehta and Eikelboom were recipients of Heart and Stroke Foundation of Canada Research Fellowship Awards. Professor Yusuf is the recipient of a Medical Research Council of Canada Senior Scientist Award and holds a Heart and Stroke Foundation of Ontario Research Chair. | Journal of the American College of Cardiology | 2001 | 364 |
| 8 | Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis | Contemporary Clinical Trials | 1997 | 359 |
| 9 | Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study | Lancet, The | 2003 | 340 |
| 10 | Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50 000 individuals | Lancet, The | 2013 | 289 |
| 11 | Randomised trials of secondary prevention programmes in coronary heart disease: systematic review | BMJ: British Medical Journal | 2001 | 286 |
| 12 | Effectiveness of comprehensive disease management programmes in improving clinical outcomes in heart failure patients. A meta-analysis | European Journal of Heart Failure | 2005 | 283 |
| 13 | Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation | Nature Genetics | 2017 | 279 |
| 14 | South Asians and Cardiovascular Risk | Circulation | 2006 | 241 |
| 15 | Benzodiazepine Versus Nonbenzodiazepine-Based Sedation for Mechanically Ventilated, Critically Ill Adults | Critical Care Medicine | 2013 | 238 |
| 16 | Role of Angiotensin Converting Enzyme Inhibitors in Patients with Left Ventricular Dysfunction and Congestive Heart Failure | European Heart Journal | 1994 | 236 |
| 17 | Increased winter mortality from acute myocardial infarction and stroke: the effect of age | Journal of the American College of Cardiology | 1999 | 226 |
| 18 | The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transcatheter Aortic Valve Replacement Centers | JACC: Cardiovascular Interventions | 2019 | 179 |
| 19 | Long-Term Effects of Ramipril on Cardiovascular Events and on Diabetes | Circulation | 2005 | 172 |
| 20 | Recurrent Stroke With Rivaroxaban Compared With Aspirin According to Predictors of Atrial Fibrillation | JAMA Neurology | 2019 | 147 |
| 21 | From the hope to the ontarget and the transcend studies: challenges in improving prognosis | American Journal of Cardiology | 2002 | 146 |
| 22 | Relationship Between Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation in Middle-Aged Healthy Men | Journal of the American College of Cardiology | 2005 | 141 |
| 23 | Oral anticoagulants in patients with coronary artery disease | Journal of the American College of Cardiology | 2003 | 140 |
| 24 | Complete vs culprit-only revascularization for patients with multivessel disease undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A systematic review and meta-analysis | American Heart Journal | 2014 | 139 |
| 25 | Why and How to Measure Aortic Valve Calcification in Patients With Aortic Stenosis | JACC: Cardiovascular Imaging | 2019 | 134 |
| 26 | Incidence, Predictive Factors, and Prognostic Significance of Supraventricular Tachyarrhythmias in Congestive Heart Failure | Chest | 2000 | 133 |
| 27 | Angiotensin receptor blockers in heart failure: meta-analysis of randomized controlled trials | Journal of the American College of Cardiology | 2002 | 132 |
| 28 | Efficacy and safety of low-dose colchicine in patients with coronary disease: a systematic review and meta-analysis of randomized trials | European Heart Journal | 2021 | 119 |
| 29 | Heart rate is associated with increased risk of major cardiovascular events, cardiovascular and all-cause death in patients with stable chronic cardiovascular disease: an analysis of ONTARGET/TRANSCEND | Clinical Research in Cardiology | 2014 | 117 |
| 30 | Fludrocortisone for the Prevention of Vasovagal Syncope | Journal of the American College of Cardiology | 2016 | 116 |
| 31 | Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice | European Journal of Heart Failure | 2005 | 111 |
| 32 | Long-Term Oral Anticoagulant Therapy in Patients With Unstable Angina or Suspected Non–Q-Wave Myocardial Infarction | Circulation | 1998 | 107 |
| 33 | Diminishing proportional risk of sudden death with advancing age: implications for prevention of sudden death | American Heart Journal | 2004 | 107 |
| 34 | Epicardial fat thickness and coronary artery disease correlate independently of obesity | International Journal of Cardiology | 2011 | 101 |
| 35 | Impact of ramipril on the incidence of atrial fibrillation: Results of the Heart Outcomes Prevention Evaluation study | American Heart Journal | 2007 | 97 |
| 36 | Prognostic capabilities of coronary computed tomographic angiography before non-cardiac surgery: prospective cohort study | BMJ, The | 2015 | 96 |
| 37 | Cardiovascular and cancer mortality among Canadians of European, south Asian and Chinese origin from 1979 to 1993: an analysis of 1.2 million deaths | Cmaj | 1999 | 96 |
| 38 | Effects of ramipril on left ventricular mass and function in cardiovascular patients with controlled blood pressure and with preserved left ventricular ejection fraction | Journal of the American College of Cardiology | 2004 | 93 |
| 39 | Calcium Antagonists in Coronary Artery Disease and Hypertension | Circulation | 1995 | 93 |
| 40 | Randomized trial of aspirin and clopidogrel versus aspirin alone for the prevention of coronary artery bypass graft occlusion: the Preoperative Aspirin and Postoperative Antiplatelets in Coronary Artery Bypass Grafting study | American Heart Journal | 2010 | 91 |
| 41 | Progression of Device-Detected Subclinical Atrial Fibrillation and the Risk of Heart Failure | Journal of the American College of Cardiology | 2018 | 91 |
| 42 | Abnormal cerebral processing of oesophageal stimuli in patients with noncardiac chest pain (NCCP) | Neurogastroenterology and Motility | 2000 | 90 |
| 43 | Relationship of glucose and insulin levels to the risk of myocardial infarction: a case-control study | Journal of the American College of Cardiology | 1999 | 88 |
| 44 | Development and validation of a generic scale for use in transition programmes to measure self‐management skills in adolescents with chronic health conditions: the TRANSITION‐Q | Child: Care, Health and Development | 2015 | 87 |
| 45 | Preferences of patients with heart failure for prognosis communication | Canadian Journal of Cardiology | 2007 | 80 |
| 46 | Risk of intracranial haemorrhage with bolus versus infusion thrombolytic therapy: a meta-analysis | Lancet, The | 2000 | 74 |
| 47 | Incidence, predictors, and clinical significance of troponin-I elevation without creatine kinase elevation following percutaneous coronary interventions | American Journal of Cardiology | 2004 | 64 |
| 48 | Repeated systematic surveillance of Kawasaki disease in Ontario from 1995 to 2006 | Pediatrics International | 2010 | 64 |
| 49 | Role of Magnesium in Reducing Mortality in Acute Myocardial Infarction | Drugs | 1993 | 59 |
| 50 | Physiological, pathological, pharmacological, biochemical and hematological factors affecting BNP and NT-proBNP | Clinical Biochemistry | 2008 | 56 |
