298
Articles
14.7K
Citations
4.2
avg. Impact Factor
66
h-index

Most Cited Articles of Integrative Biology

TitleJournalYearCitations
A transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature2007981
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's diseaseProceedings of the National Academy of Sciences of the United States of America2000714
Ghrelin octanoylation mediated by an orphan lipid transferaseProceedings of the National Academy of Sciences of the United States of America2008666
Opportunities and challenges in phenotypic drug discovery: an industry perspectiveNature Reviews Drug Discovery2017391
Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cellsProceedings of the National Academy of Sciences of the United States of America1981366
Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmissionScience2006292
Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processingBiochemistry2004263
Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cellsJournal of Pharmacology and Experimental Therapeutics2008220
Effects of parathyroid hormone on Wnt signaling pathway in boneJournal of Cellular Biochemistry2005191
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitorsNature Communications2017177
Isolation and Purification of Protein Granules from Escherichia coli Cells Overproducing Bovine Growth HormoneBio/technology1985177
Neurokinin 1 receptor antagonism as a possible therapy for alcoholismScience2008176
Conformation determines the seeding potencies of native and recombinant Tau aggregatesJournal of Biological Chemistry2015168
Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primatesBiochemical and Biophysical Research Communications2005163
Identification and expression of novel isoforms of human stromal cell-derived factor 1Gene2006161
Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male MiceEndocrinology2015151
Modern phenotypic drug discovery is a viable, neoclassic pharma strategyJournal of Medicinal Chemistry2012150
Quantitative analysis of amyloid beta peptides in cerebrospinal fluid of Alzheimer's disease patients by immunoaffinity purification and stable isotope dilution liquid chromatography/negative electrospray ionization tandem mass spectrometryRapid Communications in Mass Spectrometry2006133
Temporal gene expression analysis of monolayer cultured rat hepatocytesChemical Research in Toxicology2001132
Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experienceDiabetes Care1992132
Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthaseJournal of Cell Biology2006131
Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domainBioorganic and Medicinal Chemistry Letters2004127
The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAsNucleic Acids Research1985126
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sitesBiochemical and Biophysical Research Communications2009125
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human isletsDiabetes2010118