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Top Articles

#TitleJournalYearCitations
1Cyclin dependent kinase (CDK) inhibitors as anticancer drugsBioorganic and Medicinal Chemistry Letters2015207
2Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor GeneCancer Discovery2019152
3Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019)Bioorganic and Medicinal Chemistry Letters2019146
4Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120Cancer Discovery2016134
5Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human IsletsDiabetes2010125
6How hydrogen bonds impact P-glycoprotein transport and permeabilityBioorganic and Medicinal Chemistry Letters2012114
7Revisiting the initial rate approximation in kinetic NOE measurementsJournal of Magnetic Resonance2006111
8Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβBioorganic and Medicinal Chemistry Letters200395
9Tetrahydroquinoline-Based selective estrogen receptor modulators (SERMs)Bioorganic and Medicinal Chemistry Letters200387
10Target Engagement in Lead GenerationBioorganic and Medicinal Chemistry Letters201587
11Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3PLoS ONE201583
12Structural insights into probe-dependent positive allosterism of the GLP-1 receptorNature Chemical Biology202058
13Open Innovation for Phenotypic Drug Discovery: The PD2 Assay PanelJournal of Biomolecular Screening201155
14Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki–Hiyami–Kishi-Type AdditionJournal of the American Chemical Society201950
15Three-Dimensional Compound Comparison Methods and Their Application in Drug DiscoveryMolecules201549
16Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State ModelsJournal of Chemical Theory and Computation201847
17Cyclometalated Iridium–PhanePhos Complexes Are Active Catalysts in Enantioselective Allene–Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon StereocentersJournal of the American Chemical Society201941
18A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligandsJournal of Biological Chemistry202038
19Doubly compensated multiplicity‐edited HSQC experiments utilizing broadband inversion pulsesMagnetic Resonance in Chemistry200835
20Structural determinants of dual incretin receptor agonism by tirzepatideProceedings of the National Academy of Sciences of the United States of America202231
21The Structure and Function of the PRMT5:MEP50 ComplexSub-Cellular Biochemistry201728
22A Method for Identifying and Developing Functional Group Tolerant Catalytic Reactions: Application to the Buchwald–Hartwig AminationJournal of Organic Chemistry201728
23Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor AgonistJournal of Medicinal Chemistry201825
24PL-PatchSurfer2: Improved Local Surface Matching-Based Virtual Screening Method That Is Tolerant to Target and Ligand Structure VariationJournal of Chemical Information and Modeling201624
25Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver InjuryJournal of Medicinal Chemistry201824
26Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor AgonistsJournal of Medicinal Chemistry201322
27PL-PatchSurfer: A Novel Molecular Local Surface-Based Method for Exploring Protein-Ligand InteractionsInternational Journal of Molecular Sciences201422
28Development and Scale-Up of a Direct Asymmetric Reductive Amination with AmmoniaOrganic Process Research and Development202122
29Rapid assessment of conformational preferences in biaryl and aryl carbonyl fragmentsPLoS ONE201818
30Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discoveryPLoS ONE201816
31Enantiomeric separations using polymeric L-glutamate surfactant derivatives: Effect of increasing steric factorsElectrophoresis200315
32Cryo-electron microscopy structure of a human PRMT5:MEP50 complexPLoS ONE201815
33Crystal structure of human RIOK2 bound to a specific inhibitorOpen Biology201915
34Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug designBioorganic and Medicinal Chemistry Letters201613
35Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylateOrganic Letters201212
36Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4’s group III mGlu receptor functional potency and selectivityBioorganic and Medicinal Chemistry Letters201812
37Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740Neuropharmacology201411
38Are induced fit protein conformational changes caused by ligand‐binding predictable? A molecular dynamics investigationJournal of Computational Chemistry201710
39Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 ReceptorOrganic Process Research and Development202010
40Fragmentation of Polyfunctional Compounds Recorded Using Automated High-Throughput Desorption Electrospray IonizationJournal of the American Society for Mass Spectrometry20219
41Simple conversion of fully protected amino acids to zwitterionsTetrahedron Letters20128
42PatchSurfers: Two methods for local molecular property-based binding ligand predictionMethods20168
43Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 ReceptorJournal of Medicinal Chemistry20188
44Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phagePLoS ONE20208
45Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding SiteCurrent Topics in Medicinal Chemistry20196
46An Efficient Palladium-Catalyzed α-Arylation of Acetone Below its Boiling PointSynlett20204
47ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight FragmentsApplied Magnetic Resonance20153
48On the origin of the 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate scaffold’s unique group II selectivity for the mGlu receptorsBioorganic and Medicinal Chemistry Letters20193
49Efficient Method for the Synthesis of Amino-1,3-Oxazines from ThioureasOrganic Process Research and Development20203
50Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and developmentDrug Discovery Today20213