# | Title | Journal | Year | Citations |
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1 | Cyclin dependent kinase (CDK) inhibitors as anticancer drugs | Bioorganic and Medicinal Chemistry Letters | 2015 | 207 |
2 | Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene | Cancer Discovery | 2019 | 152 |
3 | Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015–2019) | Bioorganic and Medicinal Chemistry Letters | 2019 | 146 |
4 | Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120 | Cancer Discovery | 2016 | 134 |
5 | Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets | Diabetes | 2010 | 125 |
6 | How hydrogen bonds impact P-glycoprotein transport and permeability | Bioorganic and Medicinal Chemistry Letters | 2012 | 114 |
7 | Revisiting the initial rate approximation in kinetic NOE measurements | Journal of Magnetic Resonance | 2006 | 111 |
8 | Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCβ | Bioorganic and Medicinal Chemistry Letters | 2003 | 95 |
9 | Tetrahydroquinoline-Based selective estrogen receptor modulators (SERMs) | Bioorganic and Medicinal Chemistry Letters | 2003 | 87 |
10 | Target Engagement in Lead Generation | Bioorganic and Medicinal Chemistry Letters | 2015 | 87 |
11 | Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3 | PLoS ONE | 2015 | 83 |
12 | Structural insights into probe-dependent positive allosterism of the GLP-1 receptor | Nature Chemical Biology | 2020 | 58 |
13 | Open Innovation for Phenotypic Drug Discovery: The PD2 Assay Panel | Journal of Biomolecular Screening | 2011 | 55 |
14 | Rhodium-Catalyzed Aldehyde Arylation via Formate-Mediated Transfer Hydrogenation: Beyond Metallic Reductants in Grignard/Nozaki–Hiyami–Kishi-Type Addition | Journal of the American Chemical Society | 2019 | 50 |
15 | Three-Dimensional Compound Comparison Methods and Their Application in Drug Discovery | Molecules | 2015 | 49 |
16 | Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models | Journal of Chemical Theory and Computation | 2018 | 47 |
17 | Cyclometalated Iridium–PhanePhos Complexes Are Active Catalysts in Enantioselective Allene–Fluoral Reductive Coupling and Related Alcohol-Mediated Carbonyl Additions That Form Acyclic Quaternary Carbon Stereocenters | Journal of the American Chemical Society | 2019 | 41 |
18 | A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by heterobifunctional ligands | Journal of Biological Chemistry | 2020 | 38 |
19 | Doubly compensated multiplicity‐edited HSQC experiments utilizing broadband inversion pulses | Magnetic Resonance in Chemistry | 2008 | 35 |
20 | Structural determinants of dual incretin receptor agonism by tirzepatide | Proceedings of the National Academy of Sciences of the United States of America | 2022 | 31 |
21 | The Structure and Function of the PRMT5:MEP50 Complex | Sub-Cellular Biochemistry | 2017 | 28 |
22 | A Method for Identifying and Developing Functional Group Tolerant Catalytic Reactions: Application to the Buchwald–Hartwig Amination | Journal of Organic Chemistry | 2017 | 28 |
23 | Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist | Journal of Medicinal Chemistry | 2018 | 25 |
24 | PL-PatchSurfer2: Improved Local Surface Matching-Based Virtual Screening Method That Is Tolerant to Target and Ligand Structure Variation | Journal of Chemical Information and Modeling | 2016 | 24 |
25 | Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury | Journal of Medicinal Chemistry | 2018 | 24 |
26 | Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists | Journal of Medicinal Chemistry | 2013 | 22 |
27 | PL-PatchSurfer: A Novel Molecular Local Surface-Based Method for Exploring Protein-Ligand Interactions | International Journal of Molecular Sciences | 2014 | 22 |
28 | Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia | Organic Process Research and Development | 2021 | 22 |
29 | Rapid assessment of conformational preferences in biaryl and aryl carbonyl fragments | PLoS ONE | 2018 | 18 |
30 | Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery | PLoS ONE | 2018 | 16 |
31 | Enantiomeric separations using polymeric L-glutamate surfactant derivatives: Effect of increasing steric factors | Electrophoresis | 2003 | 15 |
32 | Cryo-electron microscopy structure of a human PRMT5:MEP50 complex | PLoS ONE | 2018 | 15 |
33 | Crystal structure of human RIOK2 bound to a specific inhibitor | Open Biology | 2019 | 15 |
34 | Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design | Bioorganic and Medicinal Chemistry Letters | 2016 | 13 |
35 | Improved Synthesis of C4α- and C4β-Methyl Analogues of 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate | Organic Letters | 2012 | 12 |
36 | Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4’s group III mGlu receptor functional potency and selectivity | Bioorganic and Medicinal Chemistry Letters | 2018 | 12 |
37 | Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740 | Neuropharmacology | 2014 | 11 |
38 | Are induced fit protein conformational changes caused by ligand‐binding predictable? A molecular dynamics investigation | Journal of Computational Chemistry | 2017 | 10 |
39 | Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor | Organic Process Research and Development | 2020 | 10 |
40 | Fragmentation of Polyfunctional Compounds Recorded Using Automated High-Throughput Desorption Electrospray Ionization | Journal of the American Society for Mass Spectrometry | 2021 | 9 |
41 | Simple conversion of fully protected amino acids to zwitterions | Tetrahedron Letters | 2012 | 8 |
42 | PatchSurfers: Two methods for local molecular property-based binding ligand prediction | Methods | 2016 | 8 |
43 | Structural Basis for (S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor | Journal of Medicinal Chemistry | 2018 | 8 |
44 | Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage | PLoS ONE | 2020 | 8 |
45 | Insights into the Structural Aspects of the mGlu Receptor Orthosteric Binding Site | Current Topics in Medicinal Chemistry | 2019 | 6 |
46 | An Efficient Palladium-Catalyzed α-Arylation of Acetone Below its Boiling Point | Synlett | 2020 | 4 |
47 | ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments | Applied Magnetic Resonance | 2015 | 3 |
48 | On the origin of the 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate scaffold’s unique group II selectivity for the mGlu receptors | Bioorganic and Medicinal Chemistry Letters | 2019 | 3 |
49 | Efficient Method for the Synthesis of Amino-1,3-Oxazines from Thioureas | Organic Process Research and Development | 2020 | 3 |
50 | Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development | Drug Discovery Today | 2021 | 3 |