| # | Title | Journal | Year | Citations |
|---|
| 1 | mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity | Science | 2014 | 1,517 |
| 2 | Resolution of the Early Placental Mammal Radiation Using Bayesian Phylogenetics | Science | 2001 | 1,215 |
| 3 | Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. | Journal of Clinical Investigation | 1998 | 1,184 |
| 4 | A Molecular Phylogeny for Bats Illuminates Biogeography and the Fossil Record | Science | 2005 | 988 |
| 5 | PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease | BioEssays | 2003 | 871 |
| 6 | AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs | Cell | 2001 | 803 |
| 7 | Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting | Science | 2002 | 768 |
| 8 | Ageing and vision: structure, stability and function of lens crystallins | Progress in Biophysics and Molecular Biology | 2004 | 742 |
| 9 | Autoantigen microarrays for multiplex characterization of autoantibody responses | Nature Medicine | 2002 | 693 |
| 10 | Murine leukemia virus-induced T-cell lymphomagenesis: Integration of proviruses in a distinct chromosomal region | Cell | 1984 | 690 |
| 11 | Parallel adaptive radiations in two major clades of placental mammals | Nature | 2001 | 626 |
| 12 | Genealogy of the α-crystallin—small heat-shock protein superfamily | International Journal of Biological Macromolecules | 1998 | 463 |
| 13 | Mutations in the RNA Component of RNase MRP Cause a Pleiotropic Human Disease, Cartilage-Hair Hypoplasia | Cell | 2001 | 461 |
| 14 | Circadian photoreception in the retinally degenerate mouse (rd/rd) | Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology | 1991 | 441 |
| 15 | Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss | FASEB Journal | 1999 | 420 |
| 16 | Evolution of the alpha-crystallin/small heat-shock protein family. | Molecular Biology and Evolution | 1993 | 417 |
| 17 | Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin | Arthritis Research | 2004 | 397 |
| 18 | The human genome encodes 10 α-crystallin–related small heat shock proteins: HspB1–10 | Cell Stress and Chaperones | 2003 | 391 |
| 19 | Preparation and characterization of porous crosslinked collagenous matrices containing bioavailable chondroitin sulphate | Biomaterials | 1999 | 389 |
| 20 | Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages | Annals of the Rheumatic Diseases | 2004 | 380 |
| 21 | Molecules consolidate the placental mammal tree | Trends in Ecology and Evolution | 2004 | 376 |
| 22 | Structural and functional features of different types of cytoplasmic fatty acid-binding proteins | Lipids and Lipid Metabolism | 1991 | 359 |
| 23 | Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones. | Journal of Biological Chemistry | 1993 | 351 |
| 24 | Structure and Modifications of the Junior Chaperone alpha-Crystallin. From Lens Transparency to Molecular Pathology | FEBS Journal | 1994 | 347 |
| 25 | Cytoplasmic fatty acid-binding proteins: Their structure and genes | Progress in Lipid Research | 1995 | 340 |
| 26 | The expanding small heat-shock protein family, and structure predictions of the conserved “α-crystallin domain” | Journal of Molecular Evolution | 1995 | 337 |
| 27 | Autoantibody profiles in the sera of European patients with myositis | Annals of the Rheumatic Diseases | 2001 | 330 |
| 28 | The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements | EMBO Journal | 2002 | 326 |
| 29 | Differential analyses of glyoxylate derivatives | Analytical Biochemistry | 1970 | 324 |
| 30 | Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones | Journal of Biological Chemistry | 1993 | 319 |
| 31 | Endemic African mammals shake the phylogenetic tree | Nature | 1997 | 316 |
| 32 | Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value | Arthritis Research | 2002 | 303 |
| 33 | Development of tailor-made collagen–glycosaminoglycan matrices: EDC/NHS crosslinking, and ultrastructural aspects | Biomaterials | 2000 | 294 |
| 34 | Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy | Annals of the Rheumatic Diseases | 2006 | 289 |
| 35 | Immobilization of heparin to EDC/NHS-crosslinked collagen. Characterization and in vitro evaluation | Biomaterials | 2001 | 277 |
| 36 | Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes | Molecular Biology Reports | 1990 | 267 |
| 37 | Influence of single amino acid substitutions on electrophoretic mobility of sodium dodecyl sulfate-protein complexes | Biochemical and Biophysical Research Communications | 1978 | 256 |
| 38 | Altered Ca2+ Responses in Muscles with Combined Mitochondrial and Cytosolic Creatine Kinase Deficiencies | Cell | 1997 | 250 |
| 39 | The enzyme lactate dehydrogenase as a structural protein in avian and crocodilian lenses | Nature | 1987 | 240 |
| 40 | The γ-Crystallins and Human Cataracts: A Puzzle Made Clearer | American Journal of Human Genetics | 1999 | 235 |
| 41 | Generation and Application of Type-specific Anti-Heparan Sulfate Antibodies Using Phage Display Technology | Journal of Biological Chemistry | 1998 | 232 |
| 42 | nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts | International Journal of Cancer | 1995 | 223 |
| 43 | The Mechanism of N-Terminal Acetylation of Protein | Critical Reviews in Biochemistry | 1985 | 221 |
| 44 | Activated leukocyte cell adhesion molecule (CD166/ALCAM): Developmental and mechanistic aspects of cell clustering and cell migration | European Journal of Cell Biology | 2002 | 220 |
| 45 | Analysis of Heavy and Light Chain Pairings Indicates that Receptor Editing Shapes the Human Antibody Repertoire | Journal of Molecular Biology | 1999 | 216 |
| 46 | Long-term outcome in polymyositis and dermatomyositis | Annals of the Rheumatic Diseases | 2006 | 215 |
| 47 | The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases | Cell | 1986 | 212 |
| 48 | Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity | Arthritis Research | 2005 | 211 |
| 49 | The human U1 snRNP-Specific U1A protein inhibits polyadenylation of its own pre-mRNA | Cell | 1993 | 210 |
| 50 | Citrullination of synovial proteins in murine models of rheumatoid arthritis | Arthritis and Rheumatism | 2003 | 209 |
