| # | Title | Journal | Year | Citations |
|---|
| 1 | Trained immunity: A program of innate immune memory in health and disease | Science | 2016 | 1,809 |
| 2 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
| 3 | An oestrogen-receptor-α-bound human chromatin interactome | Nature | 2009 | 1,537 |
| 4 | Nitrite-driven anaerobic methane oxidation by oxygenic bacteria | Nature | 2010 | 1,521 |
| 5 | mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity | Science | 2014 | 1,517 |
| 6 | The CRAPome: a contaminant repository for affinity purification–mass spectrometry data | Nature Methods | 2013 | 1,353 |
| 7 | Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity | Science | 2014 | 1,338 |
| 8 | Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 1,294 |
| 9 | The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease | Cell | 2016 | 1,052 |
| 10 | Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes | Cell Host and Microbe | 2012 | 926 |
| 11 | Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives | Cell | 2013 | 888 |
| 12 | Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters | Cell | 2016 | 863 |
| 13 | BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity | Cell Host and Microbe | 2018 | 860 |
| 14 | The Transcriptional and Epigenomic Foundations of Ground State Pluripotency | Cell | 2012 | 774 |
| 15 | Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4 | Cell | 2007 | 769 |
| 16 | HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures | Nature Medicine | 2017 | 769 |
| 17 | Non-coding recurrent mutations in chronic lymphocytic leukaemia | Nature | 2015 | 749 |
| 18 | Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers | Cell | 2010 | 710 |
| 19 | Molecular mechanism of anaerobic ammonium oxidation | Nature | 2011 | 707 |
| 20 | Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry | Nature | 2002 | 596 |
| 21 | Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity | Cell Metabolism | 2016 | 584 |
| 22 | Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells | Cell | 2016 | 573 |
| 23 | Quantitative comparison of genome-wide DNA methylation mapping technologies | Nature Biotechnology | 2010 | 534 |
| 24 | Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells | Immunity | 2016 | 510 |
| 25 | Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo | EMBO Journal | 2010 | 497 |
| 26 | Metabolic Induction of Trained Immunity through the Mevalonate Pathway | Cell | 2018 | 485 |
| 27 | β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance | Cell | 2016 | 467 |
| 28 | Proteome-wide identification of ubiquitin interactions using UbIA-MS | Nature Protocols | 2018 | 454 |
| 29 | N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis | Nature Structural and Molecular Biology | 2017 | 432 |
| 30 | Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells | Cell Stem Cell | 2013 | 424 |
| 31 | The interplay of epigenetic marks during stem cell differentiation and development | Nature Reviews Genetics | 2017 | 414 |
| 32 | The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery | Cell | 2016 | 404 |
| 33 | DNA methylation and methyl-CpG binding proteins: developmental requirements and function | Chromosoma | 2009 | 395 |
| 34 | ChIP-Seq of ERα and RNA polymerase II defines genes differentially responding to ligands | EMBO Journal | 2009 | 377 |
| 35 | Nuclear Pore Components Are Involved in the Transcriptional Regulation of Dosage Compensation in Drosophila | Molecular Cell | 2006 | 368 |
| 36 | A Central Role for P48/45 in Malaria Parasite Male Gamete Fertility | Cell | 2001 | 350 |
| 37 | Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk | Genome Research | 2012 | 344 |
| 38 | A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing | Molecular Cell | 2008 | 331 |
| 39 | MBD2/NuRD and MBD3/NuRD, Two Distinct Complexes with Different Biochemical and Functional Properties | Molecular and Cellular Biology | 2006 | 290 |
| 40 | Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner | Nature Neuroscience | 2013 | 283 |
| 41 | The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency | Nature | 2018 | 283 |
| 42 | PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia | Cancer Cell | 2010 | 276 |
| 43 | A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites | Science | 2020 | 275 |
| 44 | Trained immunity, tolerance, priming and differentiation: distinct immunological processes | Nature Immunology | 2021 | 274 |
| 45 | Transcriptional diversity during lineage commitment of human blood progenitors | Science | 2014 | 253 |
| 46 | A comprehensive evaluation of rodent malaria parasite genomes and gene expression | BMC Biology | 2014 | 251 |
| 47 | The metagenome of the marine anammox bacterium ‘Candidatus Scalindua profunda’ illustrates the versatility of this globally important nitrogen cycle bacterium | Environmental Microbiology | 2013 | 246 |
| 48 | Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors | PLoS Pathogens | 2009 | 243 |
| 49 | Whole-genome DNA methylation profiling using MethylCap-seq | Methods | 2010 | 243 |
| 50 | Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes | EMBO Journal | 2007 | 236 |
