| # | Title | Journal | Year | Citations |
|---|
| 1 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both | BMJ: British Medical Journal | 2017 | 4,681 |
| 4 | Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota | Science | 2012 | 1,785 |
| 5 | A systematic review of low back pain cost of illness studies in the United States and internationally | Spine Journal | 2008 | 1,612 |
| 6 | Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese | Nature | 1997 | 1,251 |
| 7 | Risk Factors for Alzheimer's Disease: A Prospective Analysis from the Canadian Study of Health and Aging | American Journal of Epidemiology | 2002 | 1,041 |
| 8 | Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement | Journal of Clinical Epidemiology | 2021 | 1,022 |
| 9 | Development of obesity in transgenic mice after genetic ablation of brown adipose tissue | Nature | 1993 | 1,003 |
| 10 | The Immunomodulatory and Anti-Inflammatory Role of Polyphenols | Nutrients | 2018 | 904 |
| 11 | Large‐scale mapping of human protein–protein interactions by mass spectrometry | Molecular Systems Biology | 2007 | 850 |
| 12 | Fibrin: A Versatile Scaffold for Tissue Engineering Applications | Tissue Engineering - Part B: Reviews | 2008 | 814 |
| 13 | Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT Statement | PLoS Medicine | 2010 | 801 |
| 14 | Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide | Journal of Toxicology and Environmental Health - Part B: Critical Reviews | 2007 | 741 |
| 15 | The threat of antimicrobial resistance in developing countries: causes and control strategies | Antimicrobial Resistance and Infection Control | 2017 | 714 |
| 16 | Apoptosis in Ischemic and Reperfused Rat Myocardium | Circulation Research | 1996 | 687 |
| 17 | Frequency, type and clinical importance of medication history errors at admission to hospital: a systematic review | Cmaj | 2005 | 638 |
| 18 | Loneliness and social isolation during the COVID-19 pandemic | International Psychogeriatrics | 2020 | 625 |
| 19 | A BEME systematic review of the effects of interprofessional education: BEME Guide No. 39 | Medical Teacher | 2016 | 617 |
| 20 | Long-Term Ozone Exposure and Mortality in a Large Prospective Study | American Journal of Respiratory and Critical Care Medicine | 2016 | 602 |
| 21 | Transfusion-related immunomodulation (TRIM): An update | Blood Reviews | 2007 | 570 |
| 22 | Proportion of hospital readmissions deemed avoidable: a systematic review | Cmaj | 2011 | 556 |
| 23 | A decision aid for women considering hormone therapy after menopause: decision support framework and evaluation | Patient Education and Counseling | 1998 | 526 |
| 24 | Decision rules for the use of radiography in acute ankle injuries. Refinement and prospective validation | JAMA - Journal of the American Medical Association | 1993 | 511 |
| 25 | Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes | American Journal of Physiology - Cell Physiology | 2000 | 499 |
| 26 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 27 | Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus | Diabetologia | 2003 | 473 |
| 28 | Uncoupling proteins and the control of mitochondrial reactive oxygen species production | Free Radical Biology and Medicine | 2011 | 460 |
| 29 | The GRADE Working Group clarifies the construct of certainty of evidence | Journal of Clinical Epidemiology | 2017 | 455 |
| 30 | Opioids for Chronic Noncancer Pain | JAMA - Journal of the American Medical Association | 2018 | 450 |
| 31 | Long-term Ambient Fine Particulate Matter Air Pollution and Lung Cancer in a Large Cohort of Never-Smokers | American Journal of Respiratory and Critical Care Medicine | 2011 | 439 |
| 32 | Resampling Methods for Particle Filtering: Classification, implementation, and strategies | IEEE Signal Processing Magazine | 2015 | 435 |
| 33 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 34 | HDL and Reverse Cholesterol Transport | Circulation Research | 2019 | 419 |
| 35 | COVID-19 transmission in Mainland China is associated with temperature and humidity: A time-series analysis | Science of the Total Environment | 2020 | 418 |
| 36 | YouTube as a source of information on COVID-19: a pandemic of misinformation? | BMJ Global Health | 2020 | 417 |
| 37 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 38 | The inclusion of reports of randomised trials published in languages other than English in systematic reviews | Health Technology Assessment | 2003 | 380 |
| 39 | A Combined Analysis of North American Case-Control Studies of Residential Radon and Lung Cancer | Journal of Toxicology and Environmental Health - Part A: Current Issues | 2006 | 354 |
| 40 | Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons | Current Biology | 2015 | 351 |
| 41 | Chromaffin cell cortical actin network dynamics control the size of the release-ready vesicle pool and the initial rate of exocytosis | Neuron | 1995 | 341 |
| 42 | Features of effective computerised clinical decision support systems: meta-regression of 162 randomised trials | BMJ, The | 2013 | 339 |
| 43 | Agrobacterium-transformed rice plants expressing synthetic cryIA(b) and cryIA(c) genes are highly toxic to striped stem borer and yellow stem borer | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 337 |
| 44 | Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT Statement | Journal of Evidence-Based Medicine | 2010 | 335 |
| 45 | Internal plate fixation of fractures: short history and recent developments | Journal of Orthopaedic Science | 2006 | 333 |
| 46 | Can disturbed brain microcirculation cause Alzheimer’s disease? | Neurological Research | 1993 | 329 |
| 47 | Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL−/− Renal Cancer | Cancer Research | 2005 | 329 |
| 48 | Obesity May Increase the Incidence of Asthma in Women but Not in Men: Longitudinal Observations from the Canadian National Population Health Surveys | American Journal of Epidemiology | 2002 | 327 |
| 49 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 50 | Applications of 3D printing in cardiovascular diseases | Nature Reviews Cardiology | 2016 | 318 |
