| # | Title | Journal | Year | Citations |
|---|
| 1 | Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis | Archives of Toxicology | 2018 | 230 |
| 2 | A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells | Cell Death and Disease | 2013 | 135 |
| 3 | .BETA.-Sitosterol Induces Anti-proliferation and Apoptosis in Human Leukemic U937 Cells through Activation of Caspase-3 and Induction of Bax/Bcl-2 Ratio | Biological and Pharmaceutical Bulletin | 2007 | 120 |
| 4 | Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation | Apoptosis: an International Journal on Programmed Cell Death | 2008 | 120 |
| 5 | Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPβ DNA-binding activity | Immunobiology | 2006 | 113 |
| 6 | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2003 | 102 |
| 7 | Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-κB) Activation by Inducing the Up-regulation of p21WAF1 Protein Expression * | Journal of Biological Chemistry | 2013 | 81 |
| 8 | Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-κB activation in lipopolysaccharide-induced BV2 microglial cells | Journal of Ethnopharmacology | 2011 | 79 |
| 9 | Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia | PLoS ONE | 2014 | 79 |
| 10 | Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via p21Cip/WAF1 mRNA stabilization in human epithelial cells | Toxicology | 2008 | 76 |
| 11 | Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: Involvement of ROS-dependent ER-stress | Biochemical Pharmacology | 2011 | 72 |
| 12 | In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma | Journal of Ethnopharmacology | 2012 | 70 |
| 13 | Delphinidin inhibits angiogenesis through the suppression of HIF-1α and VEGF expression in A549 lung cancer cells | Oncology Reports | 2017 | 65 |
| 14 | Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation | Food and Chemical Toxicology | 2012 | 64 |
| 15 | Hydrangenol inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-mediated HO-1 pathway | International Immunopharmacology | 2016 | 64 |
| 16 | Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells | Food and Chemical Toxicology | 2013 | 63 |
| 17 | Interleukin-5 enhances the migration and invasion of bladder cancer cells via ERK1/2-mediated MMP-9/NF-κB/AP-1 pathway: Involvement of the p21WAF1 expression | Cellular Signalling | 2013 | 62 |
| 18 | Melittin Suppresses HIF-1α/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells | PLoS ONE | 2013 | 55 |
| 19 | Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages | BMC Complementary and Alternative Medicine | 2014 | 51 |
| 20 | Rosiglitazone promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP | Free Radical Biology and Medicine | 2008 | 50 |
| 21 | Identification of Pro-Inflammatory Cytokines Associated with Muscle Invasive Bladder Cancer; The Roles of IL-5, IL-20, and IL-28A | PLoS ONE | 2012 | 50 |
| 22 | Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells | Journal of Cellular Physiology | 2007 | 49 |
| 23 | Anti-inflammatory effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway | Food and Chemical Toxicology | 2014 | 49 |
| 24 | Expression of Human Endogenous Retrovirus env Genes in the Blood of Breast Cancer Patients | International Journal of Molecular Sciences | 2014 | 48 |
| 25 | Mangiferin inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-κB activity | BMB Reports | 2015 | 47 |
| 26 | Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1 | International Immunopharmacology | 2014 | 44 |
| 27 | Hepatitis C virus core protein represses the p21 promoter through inhibition of a TGF-β pathway | Journal of General Virology | 2002 | 44 |
| 28 | Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: Involvement of Ca2+ influx | Toxicology and Applied Pharmacology | 2012 | 43 |
| 29 | Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity | Antioxidants | 2019 | 42 |
| 30 | Diesel particulate matter2.5 promotes epithelial-mesenchymal transition of human retinal pigment epithelial cells via generation of reactive oxygen species | Environmental Pollution | 2020 | 42 |
| 31 | Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells | Journal of Ethnopharmacology | 2011 | 41 |
| 32 | Apoptosis Induction of Human Prostate Carcinoma DU145 Cells by Diallyl Disulfide via Modulation of JNK and PI3K/AKT Signaling Pathways | International Journal of Molecular Sciences | 2012 | 41 |
| 33 | Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells | Cellular Immunology | 2014 | 40 |
| 34 | Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway | Antioxidants | 2020 | 40 |
| 35 | Polyphenols fromArtemisia annuaL Inhibit Adhesion and EMT of Highly Metastatic Breast Cancer Cells MDA-MB-231 | Phytotherapy Research | 2016 | 39 |
| 36 | Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation | Chemico-Biological Interactions | 2011 | 37 |
| 37 | Anti-Inflammatory Effects of Methanol Extract of Codium fragile in Lipopolysaccharide-Stimulated RAW 264.7 Cells | Journal of Medicinal Food | 2012 | 37 |
| 38 | Fermented Oyster Extract Promotes Osteoblast Differentiation by Activating the Wnt/β-Catenin Signaling Pathway, Leading to Bone Formation | Biomolecules | 2019 | 37 |
| 39 | Nrf2-Mediated HO-1 Induction Contributes to Antioxidant Capacity of a Schisandrae Fructus Ethanol Extract in C2C12 Myoblasts | Nutrients | 2014 | 36 |
| 40 | Molecular chemotherapeutic potential of butein: A concise review | Food and Chemical Toxicology | 2018 | 36 |
| 41 | Phosphorylation of NF-κB by calmodulin-dependent kinase IV activates anti-apoptotic gene expression | Biochemical and Biophysical Research Communications | 2003 | 35 |
| 42 | Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells | Archives of Biochemistry and Biophysics | 2021 | 35 |
| 43 | The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK | Apoptosis: an International Journal on Programmed Cell Death | 2009 | 34 |
| 44 | p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation | Toxicology in Vitro | 2011 | 34 |
| 45 | Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions | International Journal of Molecular Medicine | 2015 | 33 |
| 46 | Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation | Food and Chemical Toxicology | 2018 | 33 |
| 47 | Suppression of EGFR/STAT3 activity by lupeol contributes to the induction of the apoptosis of human non‑small cell lung cancer cells | International Journal of Oncology | 2019 | 33 |
| 48 | Camptothecin induces G2/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species | Oncotarget | 2018 | 33 |
| 49 | Partially purified Curcuma longa inhibits alpha‐melanocyte‐stimulating hormone‐stimulated melanogenesis through extracellular signal‐regulated kinase or Akt activation‐mediated signalling in B16F10 cells | Experimental Dermatology | 2009 | 32 |
| 50 | Aqueous fraction from Cuscuta japonica seed suppresses melanin synthesis through inhibition of the p38 mitogen-activated protein kinase signaling pathway in B16F10 cells | Journal of Ethnopharmacology | 2012 | 32 |
