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Top Articles

#TitleJournalYearCitations
1The ubiquitin pathway in Parkinson's diseaseNature19981,518
2DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNANature20071,369
3The therapeutic potential of monoamine oxidase inhibitorsNature Reviews Neuroscience20061,163
4Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α*Journal of Biological Chemistry2007966
55-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and agingNature Neuroscience2011746
6[11] Redox potential of GSH/GSSG couple: Assay and biological significanceMethods in Enzymology2002673
7Mitochondrial control of apoptosis: the role of cytochrome cBiochimica Et Biophysica Acta - Bioenergetics1998637
8BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionOncogene1998636
9Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic FunctionsPLoS ONE2013575
10Regulation of ubiquitin‐dependent processes by deubiquitinating enzymesFASEB Journal1997548
11Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmidsBioTechniques2010482
12Glutathione in Human Plasma: Decline in Association with Aging, Age-Related Macular Degeneration, and DiabetesFree Radical Biology and Medicine1998434
13Substrate Specificity of Deubiquitinating Enzymes:  Ubiquitin C-Terminal Hydrolases†Biochemistry1998381
14Mechanism of assembly of the tyrosyl radical-dinuclear iron cluster cofactor of ribonucleotide reductaseScience1991363
15Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassaNature Genetics2003351
16Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defensesFree Radical Biology and Medicine2002349
17Quantitation of free sphingosine in liver by high-performance liquid chromatographyAnalytical Biochemistry1988324
18Compartmentation of Glutathione: Implications for the Study of Toxicity and DiseaseToxicology and Applied Pharmacology1996314
19Protein lysine methyltransferase G9a acts on non-histone targetsNature Chemical Biology2008309
20Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cellsNature Genetics1999302
21Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigenNature2012283
22Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294Nature Structural and Molecular Biology2009272
23Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s diseaseMolecular Neurodegeneration2018267
24Characterization of Ceramide SynthesisJournal of Biological Chemistry1997266
25Redox Potential of Human Thioredoxin 1 and Identification of a Second Dithiol/Disulfide MotifJournal of Biological Chemistry2003264
26Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine OxidasesBiochemistry2009258
27The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modulesNature Structural and Molecular Biology2008250
28Structure of the Neurospora SET Domain Protein DIM-5, a Histone H3 Lysine MethyltransferaseCell2002247
29Evolutionary history and metabolic insights of ancient mammalian uricasesProceedings of the National Academy of Sciences of the United States of America2014238
30Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine SecretionJournal of Immunology2008232
31Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signalingNature Immunology2011230
32Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined LengthsJournal of Biological Chemistry1997207
33Cancer vaccines and carbohydrate epitopesVaccine2011203
34Apoptosis: Cell death defined by caspase activationCell Death and Differentiation1999195
35Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases:  Identification of Two Active Site Residues†Biochemistry1996194
36Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cellsAmerican Journal of Physiology - Renal Physiology2002194
37Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible InhibitorsJournal of Biological Chemistry2005189
38Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like ProteinsMolecular and Cellular Biology2004184
39Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissueBiochimica Et Biophysica Acta - General Subjects1977178
40Shotgun glycomics: a microarray strategy for functional glycomicsNature Methods2011176
41Colonic Cell Proliferation and Aberrant Crypt Foci Formation Are Inhibited by Dairy Glycosphingolipids in 1,2-Dimethylhydrazine-Treated CF1 MiceJournal of Nutrition2000173
42Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle CellsJournal of Biological Chemistry1995168
43The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding foldsNature Structural Biology2002168
44Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed miceScience Translational Medicine2016160
45Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosisScience Translational Medicine2012159
46A Mitochondrial DNA Mutation as a Cause of Leber's Hereditary Optic NeuropathyNew England Journal of Medicine1989158
47DEN1 Is a Dual Function Protease Capable of Processing the C Terminus of Nedd8 and Deconjugating Hyper-neddylated CUL1Journal of Biological Chemistry2003154
48Multicopy Suppression Underpins Metabolic EvolvabilityMolecular Biology and Evolution2007154
49Glutathione in foods listed in the national cancer institute's health habits and history food frequency questionnaireNutrition and Cancer1992153
50Regulation of proteolysis by human deubiquitinating enzymesBiochimica Et Biophysica Acta - Molecular Cell Research2014149