| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 2 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 3 | Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression | Journal of Immunology | 2001 | 1,185 |
| 4 | Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses | Nature Immunology | 2007 | 932 |
| 5 | Perivascular Epithelioid Cell Neoplasms of Soft Tissue and Gynecologic Origin | American Journal of Surgical Pathology | 2005 | 820 |
| 6 | Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms | Journal of Immunology | 2003 | 793 |
| 7 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 8 | A Cathepsin D-Cleaved 16 kDa Form of Prolactin Mediates Postpartum Cardiomyopathy | Cell | 2007 | 736 |
| 9 | Histopathologic Diagnosis of Fungal Infections in the 21st Century | Clinical Microbiology Reviews | 2011 | 712 |
| 10 | Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor | Nature | 1995 | 710 |
| 11 | Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty | Journal of the American College of Cardiology | 1985 | 590 |
| 12 | Most Osteomalacia-associated Mesenchymal Tumors Are a Single Histopathologic Entity | American Journal of Surgical Pathology | 2004 | 587 |
| 13 | Atypical and Malignant Glomus Tumors | American Journal of Surgical Pathology | 2001 | 569 |
| 14 | Cytokine regulation of tight junctions | Biochimica Et Biophysica Acta - Biomembranes | 2009 | 564 |
| 15 | Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing | Journal of Virology | 2008 | 540 |
| 16 | Extragastrointestinal (Soft Tissue) Stromal Tumors: An Analysis of 48 Cases with Emphasis on Histologic Predictors of Outcome | Modern Pathology | 2000 | 447 |
| 17 | Human junction adhesion molecule regulates tight junction resealing in epithelia | Journal of Cell Science | 2000 | 446 |
| 18 | Regulation of Nox and Duox enzymatic activity and expression | Free Radical Biology and Medicine | 2007 | 444 |
| 19 | Guidelines on the use of therapeutic apheresis in clinical practice—Evidence‐based approach from the apheresis applications committee of the American Society for Apheresis | Journal of Clinical Apheresis | 2010 | 441 |
| 20 | Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins | American Journal of Pathology | 2001 | 427 |
| 21 | Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy | Nature Medicine | 2004 | 420 |
| 22 | IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells | American Journal of Physiology - Renal Physiology | 2000 | 418 |
| 23 | Three Emerging Coronaviruses in Two Decades | American Journal of Clinical Pathology | 2020 | 417 |
| 24 | Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis | Journal of Cell Biology | 2003 | 411 |
| 25 | Microbial Translocation in the Pathogenesis of HIV Infection and AIDS | Clinical Microbiology Reviews | 2013 | 404 |
| 26 | Morphologic and Immunophenotypic Diversity in Ewing Family Tumors | American Journal of Surgical Pathology | 2005 | 376 |
| 27 | Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study | BMJ: British Medical Journal | 2002 | 355 |
| 28 | Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment | Molecular Biology of the Cell | 2004 | 350 |
| 29 | HIV‐associated chronic immune activation | Immunological Reviews | 2013 | 349 |
| 30 | Triple-negative breast cancer has worse overall survival and cause-specific survival than non-triple-negative breast cancer | Breast Cancer Research and Treatment | 2017 | 335 |
| 31 | Genetic and Neutralization Properties of Subtype C Human Immunodeficiency Virus Type 1 Molecular env Clones from Acute and Early Heterosexually Acquired Infections in Southern Africa | Journal of Virology | 2006 | 334 |
| 32 | Gallbladder Cancer: expert consensus statement | Hpb | 2015 | 334 |
| 33 | Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma | Science Translational Medicine | 2011 | 328 |
| 34 | Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016) | Journal of Pediatric Gastroenterology and Nutrition | 2017 | 328 |
| 35 | Interferon‐γ induces internalization of epithelial tight junction proteins via a macropinocytosis‐like process | FASEB Journal | 2005 | 319 |
| 36 | Immunohistochemical Detection of FLI-1 Protein Expression | American Journal of Surgical Pathology | 2000 | 316 |
| 37 | Methyl CpG-binding proteins and transcriptional repression | BioEssays | 2001 | 315 |
| 38 | Low-Grade Fibromyxoid Sarcoma and Hyalinizing Spindle Cell Tumor With Giant Rosettes | American Journal of Surgical Pathology | 2000 | 308 |
| 39 | Guidelines on the use of therapeutic apheresis in clinical practice—Evidence-based approach from the apheresis applications committee of the American society for apheresis | Journal of Clinical Apheresis | 2007 | 308 |
| 40 | Mechanism of IFN-γ-induced Endocytosis of Tight Junction Proteins: Myosin II-dependent Vacuolarization of the Apical Plasma Membrane | Molecular Biology of the Cell | 2005 | 305 |
| 41 | Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation | American Journal of Pathology | 2010 | 304 |
| 42 | Inflammatory Genital Infections Mitigate a Severe Genetic Bottleneck in Heterosexual Transmission of Subtype A and C HIV-1 | PLoS Pathogens | 2009 | 298 |
| 43 | Dual nature of the adaptive immune system in lampreys | Nature | 2009 | 296 |
| 44 | Markedly Elevated Levels of Interferon (IFN)‐σ, IFN‐α, Interleukin (IL)‐2, IL‐10, and Tumor Necrosis Factor‐α Associated with Fatal Ebola Virus Infection | Journal of Infectious Diseases | 1999 | 278 |
| 45 | Expression of Fli-1, a Nuclear Transcription Factor, Distinguishes Vascular Neoplasms From Potential Mimics | American Journal of Surgical Pathology | 2001 | 278 |
| 46 | Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases | American Journal of Surgical Pathology | 2005 | 267 |
| 47 | Clear Cell Myomelanocytic Tumor of the Falciform Ligament/Ligamentum Teres | American Journal of Surgical Pathology | 2000 | 264 |
| 48 | Epstein-Barr Virus-Associated Smooth Muscle Tumors Are Distinctive Mesenchymal Tumors Reflecting Multiple Infection Events | American Journal of Surgical Pathology | 2006 | 263 |
| 49 | Renal interstitial fibrosis | Current Opinion in Nephrology and Hypertension | 2012 | 261 |
| 50 | Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis | Journal of Immunology | 2002 | 245 |
