| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure | Cell | 2016 | 1,680 |
| 3 | Comparison of Warfarin and Aspirin for Symptomatic Intracranial Arterial Stenosis | New England Journal of Medicine | 2005 | 1,620 |
| 4 | The ubiquitin pathway in Parkinson's disease | Nature | 1998 | 1,518 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression | JAMA Psychiatry | 2013 | 1,314 |
| 7 | The therapeutic potential of monoamine oxidase inhibitors | Nature Reviews Neuroscience | 2006 | 1,163 |
| 8 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 9 | Role of oxidative stress in atherosclerosis | American Journal of Cardiology | 2003 | 1,073 |
| 10 | Cognitive Enhancers as Adjuncts to Psychotherapy | Archives of General Psychiatry | 2004 | 1,023 |
| 11 | Classical Nuclear Localization Signals: Definition, Function, and Interaction with Importin α* | Journal of Biological Chemistry | 2007 | 966 |
| 12 | Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine | Nature Biotechnology | 2011 | 955 |
| 13 | Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection | Journal of Experimental Medicine | 2011 | 775 |
| 14 | The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients | Science Immunology | 2020 | 772 |
| 15 | Systems biology of vaccination for seasonal influenza in humans | Nature Immunology | 2011 | 749 |
| 16 | 5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging | Nature Neuroscience | 2011 | 746 |
| 17 | Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling | Pharmacological Reviews | 2002 | 655 |
| 18 | Rational Development of LEA29Y (belatacept), a High‐Affinity Variant of CTLA4‐Ig with Potent Immunosuppressive Properties | American Journal of Transplantation | 2005 | 655 |
| 19 | Stone agers in the fast lane: Chronic degenerative diseases in evolutionary perspective | American Journal of Medicine | 1988 | 629 |
| 20 | Health Literacy and Preventive Health Care Use Among Medicare Enrollees in a Managed Care Organization | Medical Care | 2002 | 606 |
| 21 | Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology | Toxicology and Applied Pharmacology | 1997 | 604 |
| 22 | Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion | Nature Genetics | 1992 | 602 |
| 23 | CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS | Depression and Anxiety | 2013 | 589 |
| 24 | Extracorporeal Life Support Organization Registry Report 2012 | ASAIO Journal | 2013 | 577 |
| 25 | Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation | Cell | 2017 | 567 |
| 26 | In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells | Nature Nanotechnology | 2009 | 544 |
| 27 | The transcriptional landscape of age in human peripheral blood | Nature Communications | 2015 | 533 |
| 28 | ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury | Annals of Emergency Medicine | 2007 | 522 |
| 29 | Absorption kinetics of misoprostol with oral or vaginal administration | Obstetrics and Gynecology | 1997 | 520 |
| 30 | Redox state of glutathione in human plasma | Free Radical Biology and Medicine | 2000 | 509 |
| 31 | Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming | Cell | 2013 | 502 |
| 32 | Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program | Nature Genetics | 2018 | 497 |
| 33 | α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle | Nature | 1987 | 492 |
| 34 | Huntingtin–protein interactions and the pathogenesis of Huntington's disease | Trends in Genetics | 2004 | 479 |
| 35 | Two rice phosphate transporters, OsPht1;2 and OsPht1;6, have different functions and kinetic properties in uptake and translocation | Plant Journal | 2009 | 470 |
| 36 | Influenza Vaccination of Pregnant Women and Protection of Their Infants | New England Journal of Medicine | 2014 | 463 |
| 37 | The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness | Nature | 2010 | 451 |
| 38 | Drugs that target dynamic microtubules: A new molecular perspective | Medicinal Research Reviews | 2011 | 439 |
| 39 | Glutathione in Human Plasma: Decline in Association with Aging, Age-Related Macular Degeneration, and Diabetes | Free Radical Biology and Medicine | 1998 | 434 |
| 40 | Fine-tuning of GPCR activity by receptor-interacting proteins | Nature Reviews Molecular Cell Biology | 2009 | 413 |
| 41 | A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands | ACS Nano | 2010 | 395 |
| 42 | Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells | Journal of Cell Biology | 2003 | 377 |
| 43 | Microarray-based genomic selection for high-throughput resequencing | Nature Methods | 2007 | 374 |
| 44 | Reactive oxygen species as mediators of angiotensin II signaling | Regulatory Peptides | 2000 | 372 |
| 45 | Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 371 |
| 46 | Structural basis for partial agonist action at ionotropic glutamate receptors | Nature Neuroscience | 2003 | 364 |
| 47 | Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse | Blood | 2011 | 353 |
| 48 | Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa | Nature Genetics | 2003 | 351 |
| 49 | The Nature of Nurture: Refining the Definition of the Exposome | Toxicological Sciences | 2014 | 350 |
| 50 | Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses | Free Radical Biology and Medicine | 2002 | 349 |
