| # | Title | Journal | Year | Citations |
|---|
| 1 | Fetal and infant growth and impaired glucose tolerance at age 64. | BMJ: British Medical Journal | 1991 | 2,326 |
| 2 | Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth | Diabetologia | 1993 | 2,271 |
| 3 | The thrifty phenotype hypothesis | British Medical Bulletin | 2001 | 2,196 |
| 4 | Glucose tolerance in adults after prenatal exposure to famine | Lancet, The | 1998 | 1,427 |
| 5 | Lysosomes: fusion and function | Nature Reviews Molecular Cell Biology | 2007 | 1,397 |
| 6 | Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling | Biochemical Journal | 1998 | 924 |
| 7 | TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction | Nature Genetics | 2009 | 817 |
| 8 | PPAR and human metabolic disease | Journal of Clinical Investigation | 2006 | 717 |
| 9 | ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function | Neuron | 2015 | 716 |
| 10 | α-Synuclein impairs macroautophagy: implications for Parkinson’s disease | Journal of Cell Biology | 2010 | 687 |
| 11 | TNF‐α and adipocyte biology | FEBS Letters | 2008 | 624 |
| 12 | Clathrin-mediated endocytosis in AP-2–depleted cells | Journal of Cell Biology | 2003 | 618 |
| 13 | Understanding Oral Glucose Tolerance: Comparison of Glucose or Insulin Measurements During the Oral Glucose Tolerance Test with Specific Measurements of Insulin Resistance and Insulin Secretion | Diabetic Medicine | 1994 | 591 |
| 14 | Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer | Journal of Cell Biology | 2004 | 563 |
| 15 | Catch-up growth and obesity in male mice | Nature | 2004 | 555 |
| 16 | Molecular Architecture and Functional Model of the Endocytic AP2 Complex | Cell | 2002 | 522 |
| 17 | Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 519 |
| 18 | A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2 | Science | 2004 | 509 |
| 19 | Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation | Journal of Lipid Research | 2007 | 445 |
| 20 | ADAPTORS FOR CLATHRIN COATS: Structure and Function | Annual Review of Cell and Developmental Biology | 2004 | 435 |
| 21 | Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases | Nature | 1988 | 428 |
| 22 | Fetal and infant growth and cardiovascular risk factors in women | BMJ: British Medical Journal | 1995 | 406 |
| 23 | Sulfonylurea Stimulation of Insulin Secretion | Diabetes | 2002 | 393 |
| 24 | Mutation in AP-3 δ in the mocha Mouse Links Endosomal Transport to Storage Deficiency in Platelets, Melanosomes, and Synaptic Vesicles | Neuron | 1998 | 382 |
| 25 | DNA damage, cellular senescence and organismal ageing: causal or correlative? | Nucleic Acids Research | 2007 | 374 |
| 26 | Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy | Nature Communications | 2014 | 374 |
| 27 | Mutations in the Pericentrin ( PCNT ) Gene Cause Primordial Dwarfism | Science | 2008 | 370 |
| 28 | Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins | Biochemical Journal | 1989 | 367 |
| 29 | Characterization of the Adaptor-related Protein Complex, AP-3 | Journal of Cell Biology | 1997 | 358 |
| 30 | Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection | Hepatology | 1999 | 358 |
| 31 | Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators | Cell | 1992 | 355 |
| 32 | Clathrin and adaptors | Biochimica Et Biophysica Acta - Molecular Cell Research | 1998 | 349 |
| 33 | Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake | Neuron | 2006 | 345 |
| 34 | A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line | Diabetes | 2003 | 341 |
| 35 | Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in East London Asians | Diabetologia | 1995 | 337 |
| 36 | The role of clathrin, adaptors and dynamin in endocytosis | Current Opinion in Cell Biology | 1994 | 328 |
| 37 | Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5 | Journal of Cell Science | 2009 | 328 |
| 38 | The Role of Intraorganellar Ca2+In Late Endosome–Lysosome Heterotypic Fusion and in the Reformation of Lysosomes from Hybrid Organelles | Journal of Cell Biology | 2000 | 325 |
| 39 | Organ-selective growth in the offspring of protein-restricted mothers | British Journal of Nutrition | 1996 | 323 |
| 40 | A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome | Journal of Cell Biology | 2000 | 315 |
| 41 | A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex | Cell | 2010 | 305 |
| 42 | Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice | Diabetes | 2011 | 297 |
| 43 | Fishing in the Stream of Diabetes: From Measuring Insulin to the Control of Fetal Organogenesis | Biochemical Society Transactions | 1996 | 296 |
| 44 | Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity | Diabetes | 2007 | 280 |
| 45 | A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex | Nature | 2008 | 280 |
| 46 | Characterization of a Fourth Adaptor-related Protein Complex | Molecular Biology of the Cell | 1999 | 276 |
| 47 | Low birthweight is associated with specific changes in muscle insulin-signalling protein expression | Diabetologia | 2005 | 270 |
| 48 | Pathways to the analysis of microarray data | Trends in Biotechnology | 2005 | 269 |
| 49 | Early growth determines longevity in male rats and may be related to telomere shortening in the kidney | FEBS Letters | 1999 | 265 |
| 50 | Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action | PLoS Biology | 2003 | 262 |
