| # | Title | Journal | Year | Citations |
|---|
| 1 | Establishment in culture of pluripotential cells from mouse embryos | Nature | 1981 | 7,627 |
| 2 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 3 | Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease | Nature Genetics | 2004 | 2,188 |
| 4 | A subcellular map of the human proteome | Science | 2017 | 2,079 |
| 5 | Codon-Substitution Models for Heterogeneous Selection Pressure at Amino Acid Sites | Genetics | 2000 | 2,064 |
| 6 | Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans | Nature | 2003 | 1,998 |
| 7 | The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration | Nature Biotechnology | 2007 | 1,955 |
| 8 | Molecular drive: a cohesive mode of species evolution | Nature | 1982 | 1,578 |
| 9 | Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene | Nature | 1994 | 1,476 |
| 10 | Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines | Nature | 1984 | 1,401 |
| 11 | Identifying and removing haplotypic duplication in primary genome assemblies | Bioinformatics | 2020 | 1,221 |
| 12 | Towards complete and error-free genome assemblies of all vertebrate species | Nature | 2021 | 1,139 |
| 13 | Circular transcripts of the testis-determining gene Sry in adult mouse testis | Cell | 1993 | 999 |
| 14 | The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster | PLoS Biology | 2008 | 999 |
| 15 | A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae | Nature Biotechnology | 2016 | 985 |
| 16 | Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project | Science | 2010 | 912 |
| 17 | Age-specific mortality and immunity patterns of SARS-CoV-2 | Nature | 2021 | 883 |
| 18 | Lithium induces autophagy by inhibiting inositol monophosphatase | Journal of Cell Biology | 2005 | 868 |
| 19 | An African origin for the intimate association between humans and Helicobacter pylori | Nature | 2007 | 826 |
| 20 | Ten things you should know about transposable elements | Genome Biology | 2018 | 817 |
| 21 | Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects | Neuron | 1995 | 810 |
| 22 | RNA modifications modulate gene expression during development | Science | 2018 | 762 |
| 23 | Birth of the D-E-A-D box | Nature | 1989 | 745 |
| 24 | Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector | Nature | 1986 | 744 |
| 25 | Unlocking the secrets of the genome | Nature | 2009 | 744 |
| 26 | Novel targets for Huntington's disease in an mTOR-independent autophagy pathway | Nature Chemical Biology | 2008 | 739 |
| 27 | Lysosomal positioning coordinates cellular nutrient responses | Nature Cell Biology | 2011 | 726 |
| 28 | Molecular Genetics of the Bithorax Complex in Drosophila melanogaster | Science | 1983 | 716 |
| 29 | α-Synuclein impairs macroautophagy: implications for Parkinson’s disease | Journal of Cell Biology | 2010 | 687 |
| 30 | Nonamplifying alleles at microsatellite loci: a caution for parentage and population studies | Molecular Ecology | 1995 | 684 |
| 31 | Earth BioGenome Project: Sequencing life for the future of life | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 652 |
| 32 | FlyBase: enhancing Drosophila Gene Ontology annotations | Nucleic Acids Research | 2009 | 648 |
| 33 | Stage-specific embryonic antigen involves αl→ 3 fucosylated type 2 blood group chains | Nature | 1981 | 642 |
| 34 | The Sequence Ontology: a tool for the unification of genome annotations | Genome Biology | 2005 | 638 |
| 35 | A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22 | Nature Genetics | 1996 | 635 |
| 36 | Cryptic simplicity in DNA is a major source of genetic variation | Nature | 1986 | 621 |
| 37 | A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis | Nature Biotechnology | 2008 | 619 |
| 38 | The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A | Nature | 1988 | 602 |
| 39 | Systematic determination of patterns of gene expression during Drosophila embryogenesis | Genome Biology | 2002 | 600 |
| 40 | Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis | Journal of Cell Biology | 2001 | 590 |
| 41 | The HUPO PSI's Molecular Interaction format—a community standard for the representation of protein interaction data | Nature Biotechnology | 2004 | 581 |
| 42 | Small molecules enhance autophagy and reduce toxicity in Huntington's disease models | Nature Chemical Biology | 2007 | 572 |
| 43 | Polo-like kinases: conservation and divergence in their functions and regulation | Nature Reviews Molecular Cell Biology | 2009 | 554 |
| 44 | SAK/PLK4 Is Required for Centriole Duplication and Flagella Development | Current Biology | 2005 | 553 |
| 45 | Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions | PLoS Biology | 2003 | 545 |
| 46 | Uberon, an integrative multi-species anatomy ontology | Genome Biology | 2012 | 545 |
| 47 | Insights into human genetic variation and population history from 929 diverse genomes | Science | 2020 | 534 |
| 48 | Advances in our understanding of mammalian sex-biased dispersal | Molecular Ecology | 2007 | 533 |
| 49 | A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice | Nature | 1987 | 509 |
| 50 | Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project | Nature Biotechnology | 2008 | 506 |
