| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China | Kidney International | 2020 | 1,388 |
| 3 | Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system | Journal of Nanoparticle Research | 2008 | 328 |
| 4 | Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway | Neuropharmacology | 2014 | 175 |
| 5 | 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential | MedChemComm | 2015 | 169 |
| 6 | Conformational restriction: an effective tactic in 'follow-on'-based drug discovery | Future Medicinal Chemistry | 2014 | 163 |
| 7 | The Cardioprotection of the Insulin-Mediated PI3K/Akt/mTOR Signaling Pathway | American Journal of Cardiovascular Drugs | 2014 | 161 |
| 8 | Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action | Neuroscience Letters | 2005 | 157 |
| 9 | The Histone Demethylase RBP2 Is Overexpressed in Gastric Cancer and Its Inhibition Triggers Senescence of Cancer Cells | Gastroenterology | 2010 | 150 |
| 10 | The urokinase plasminogen activator system in breast cancer invasion and metastasis | Biomedicine and Pharmacotherapy | 2013 | 150 |
| 11 | New insight into isolation, identification techniques and medical applications of exosomes | Journal of Controlled Release | 2019 | 130 |
| 12 | Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death | Bioorganic and Medicinal Chemistry | 2011 | 113 |
| 13 | The roles of ZEB1 in tumorigenic progression and epigenetic modifications | Biomedicine and Pharmacotherapy | 2019 | 106 |
| 14 | Combinational strategies of metformin and chemotherapy in cancers | Cancer Chemotherapy and Pharmacology | 2016 | 105 |
| 15 | Nrf2–ARE signaling pathway and natural products for cancer chemoprevention | Cancer Epidemiology | 2010 | 101 |
| 16 | (−)-Epigallocatechin Gallate Protects Against Cerebral Ischemia-Induced Oxidative Stress via Nrf2/ARE Signaling | Neurochemical Research | 2014 | 99 |
| 17 | Structural basis of GPBAR activation and bile acid recognition | Nature | 2020 | 96 |
| 18 | Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activity | Neuroscience | 2015 | 94 |
| 19 | Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease | Brain, Behavior, and Immunity | 2021 | 93 |
| 20 | Elevated expression of the centromere protein‐A(CENP‐A)‐encoding gene as a prognostic and predictive biomarker in human cancers | International Journal of Cancer | 2016 | 92 |
| 21 | Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex | Nature | 2021 | 90 |
| 22 | Metformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo | Molecular Carcinogenesis | 2018 | 89 |
| 23 | Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation | Biochemical and Biophysical Research Communications | 2010 | 88 |
| 24 | Deficiency of Interferon-Gamma or Its Receptor Promotes Colorectal Cancer Development | Journal of Interferon and Cytokine Research | 2015 | 84 |
| 25 | Bioluminescent Probe for Hydrogen Peroxide Imaging in Vitro and in Vivo | Analytical Chemistry | 2014 | 83 |
| 26 | TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease | Experimental Neurology | 2018 | 83 |
| 27 | A biodegradable chitosan-based composite film reinforced by ramie fibre and lignin for food packaging | Carbohydrate Polymers | 2022 | 83 |
| 28 | MMP-9, a Potential Target for Cerebral Ischemic Treatment | Current Neuropharmacology | 2009 | 80 |
| 29 | S‐allyl cysteine activates the Nrf2‐dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo | Journal of Neurochemistry | 2015 | 78 |
| 30 | Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism | Cell Metabolism | 2020 | 77 |
| 31 | The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment | Biomedicine and Pharmacotherapy | 2016 | 72 |
| 32 | Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes | Food and Chemical Toxicology | 2008 | 71 |
| 33 | Molecular regulation of galectin-3 expression and therapeutic implication in cancer progression | Biomedicine and Pharmacotherapy | 2016 | 71 |
| 34 | Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes | Neurochemistry International | 2010 | 69 |
| 35 | Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells | Carcinogenesis | 2012 | 68 |
| 36 | Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence | Current Neuropharmacology | 2014 | 68 |
| 37 | NOD2 is Involved in the Inflammatory Response after Cerebral Ischemia-Reperfusion Injury and Triggers NADPH Oxidase 2-Derived Reactive Oxygen Species | International Journal of Biological Sciences | 2015 | 67 |
| 38 | New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer | Biomedicine and Pharmacotherapy | 2017 | 66 |
| 39 | Beneficial effects of melatonin in experimental models of Alzheimer disease1 | Acta Pharmacologica Sinica | 2006 | 65 |
| 40 | Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway | Neurochemistry International | 2012 | 65 |
| 41 | Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents | ACS Medicinal Chemistry Letters | 2013 | 65 |
| 42 | High expression of α 2, 3-linked sialic acid residues is associated with the metastatic potential of human gastric cancer | Cancer Detection and Prevention | 2009 | 62 |
| 43 | The anti-fatty liver effects of garlic oil on acute ethanol-exposed mice | Chemico-Biological Interactions | 2008 | 61 |
| 44 | m6A regulator-mediated methylation modification patterns and characteristics of immunity and stemness in low-grade glioma | Briefings in Bioinformatics | 2021 | 57 |
| 45 | In vitro and in vivo antitumor activity of oridonin nanosuspension | International Journal of Pharmaceutics | 2009 | 56 |
| 46 | Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor/nuclear factor-κB pathway in brain microvascular endothelial cells | Life Sciences | 2006 | 55 |
| 47 | Role of the interaction between galectin-3 and cell adhesion molecules in cancer metastasis | Biomedicine and Pharmacotherapy | 2015 | 55 |
| 48 | The role of galectin-4 in physiology and diseases | Protein and Cell | 2016 | 55 |
| 49 | FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models | Neurochemical Research | 2017 | 55 |
| 50 | Neuroprotective Effects of Tanshinone I Against 6-OHDA-Induced Oxidative Stress in Cellular and Mouse Model of Parkinson’s Disease Through Upregulating Nrf2 | Neurochemical Research | 2016 | 54 |
