# | Title | Journal | Year | Citations |
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1 | Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends | Journal of Medicinal Chemistry | 2016 | 260 |
2 | Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy | ACS Nano | 2019 | 238 |
3 | HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production | Journal of Hepatology | 2017 | 232 |
4 | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling | Signal Transduction and Targeted Therapy | 2020 | 232 |
5 | Thiadiazole—a Promising Structure in Medicinal Chemistry | ChemMedChem | 2013 | 203 |
6 | The Structure and Main Functions of Aminopeptidase N | Current Medicinal Chemistry | 2007 | 192 |
7 | Current drug research on PEGylation with small molecular agents | Progress in Polymer Science | 2013 | 190 |
8 | Transition Metal-Catalyzed Selective Carbon–Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition Reactions | Chemical Reviews | 2021 | 187 |
9 | Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities | Journal of Medicinal Chemistry | 2020 | 183 |
10 | Cage the firefly luciferin! – a strategy for developing bioluminescent probes | Chemical Society Reviews | 2013 | 172 |
11 | 8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential | MedChemComm | 2015 | 169 |
12 | Conformational restriction: an effective tactic in 'follow-on'-based drug discovery | Future Medicinal Chemistry | 2014 | 163 |
13 | HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug design | Medicinal Research Reviews | 2013 | 161 |
14 | Fsp3: A new parameter for drug-likeness | Drug Discovery Today | 2020 | 156 |
15 | Recent applications of click chemistry in drug discovery | Expert Opinion on Drug Discovery | 2019 | 151 |
16 | Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial libraries | Drug Discovery Today | 2016 | 138 |
17 | The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic | Journal of Medicinal Chemistry | 2019 | 124 |
18 | Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative Paradigms | Journal of Medicinal Chemistry | 2012 | 115 |
19 | Progress in the Development of Matrix Metalloproteinase Inhibitors | Current Medicinal Chemistry | 2008 | 112 |
20 | Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studies | Colloids and Surfaces B: Biointerfaces | 2010 | 109 |
21 | Recent Development of Benzimidazole‐Containing Antibacterial Agents | ChemMedChem | 2016 | 108 |
22 | Overview of Recent Strategic Advances in Medicinal Chemistry | Journal of Medicinal Chemistry | 2019 | 108 |
23 | Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles | Journal of Medicinal Chemistry | 2016 | 107 |
24 | Trend of Histone Deacetylase Inhibitors in Cancer Therapy: Isoform Selectivity or Multitargeted Strategy | Medicinal Research Reviews | 2015 | 106 |
25 | A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies | Medicinal Research Reviews | 2020 | 106 |
26 | Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms | Journal of Medicinal Chemistry | 2017 | 101 |
27 | Recent Advances in Synthetic α‐Glucosidase Inhibitors | ChemMedChem | 2017 | 100 |
28 | Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma | British Journal of Cancer | 2015 | 99 |
29 | How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials | Journal of Chemical Information and Modeling | 2013 | 97 |
30 | Recent Advance in the Research of Flavonoids as Anticancer Agents | Mini-Reviews in Medicinal Chemistry | 2007 | 93 |
31 | Design Strategies of Novel NNRTIs to Overcome Drug Resistance | Current Medicinal Chemistry | 2009 | 92 |
32 | Preparation and characterization of silybin-loaded nanostructured lipid carriers | Drug Delivery | 2010 | 92 |
33 | Recent Advances in DAPYs and Related Analogues as HIV-1 NNRTIs | Current Medicinal Chemistry | 2011 | 92 |
34 | 1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents | Mini-Reviews in Medicinal Chemistry | 2011 | 90 |
35 | Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases | European Journal of Medicinal Chemistry | 2020 | 90 |
36 | Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria | Current Drug Targets | 2016 | 90 |
37 | Structure and Functions of Influenza Virus Neuraminidase | Current Medicinal Chemistry | 2007 | 87 |
38 | Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities | Journal of Medicinal Chemistry | 2011 | 85 |
39 | Recent development of boronic acid-based fluorescent sensors | RSC Advances | 2018 | 84 |
40 | Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses | Chemical Society Reviews | 2021 | 84 |
41 | Bioluminescent Probe for Hydrogen Peroxide Imaging in Vitro and in Vivo | Analytical Chemistry | 2014 | 83 |
42 | Bioluminescence Probe for Detecting Hydrogen Sulfide in Vivo | Analytical Chemistry | 2016 | 83 |
43 | Store-operated CRAC channel inhibitors: opportunities and challenges | Future Medicinal Chemistry | 2016 | 82 |
44 | New techniques and strategies in drug discovery | Chinese Chemical Letters | 2020 | 82 |
45 | Strategies in developing promising histone deacetylase inhibitors | Medicinal Research Reviews | 2010 | 81 |
46 | Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present) | Expert Opinion on Therapeutic Patents | 2020 | 81 |
47 | Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants | Journal of Medicinal Chemistry | 2017 | 79 |
48 | Characterization of exosomes derived from <em>Toxoplasma gondii</em> and their functions in modulating immune responses | International Journal of Nanomedicine | 2018 | 79 |
49 | Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously | Journal of Medicinal Chemistry | 2018 | 78 |
50 | Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis | ACS Chemical Neuroscience | 2017 | 77 |