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Top Articles

#TitleJournalYearCitations
1Anti-HIV Drug Discovery and Development: Current Innovations and Future TrendsJournal of Medicinal Chemistry2016260
2Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal TherapyACS Nano2019238
3HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS productionJournal of Hepatology2017232
4Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signalingSignal Transduction and Targeted Therapy2020232
5Thiadiazole—a Promising Structure in Medicinal ChemistryChemMedChem2013203
6The Structure and Main Functions of Aminopeptidase NCurrent Medicinal Chemistry2007192
7Current drug research on PEGylation with small molecular agentsProgress in Polymer Science2013190
8Transition Metal-Catalyzed Selective Carbon–Carbon Bond Cleavage of Vinylcyclopropanes in Cycloaddition ReactionsChemical Reviews2021187
9Inhibitors of SARS-CoV-2 Entry: Current and Future OpportunitiesJournal of Medicinal Chemistry2020183
10Cage the firefly luciferin! – a strategy for developing bioluminescent probesChemical Society Reviews2013172
118-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potentialMedChemComm2015169
12Conformational restriction: an effective tactic in 'follow-on'-based drug discoveryFuture Medicinal Chemistry2014163
13HIV‐1 NNRTIs: structural diversity, pharmacophore similarity, and impliations for drug designMedicinal Research Reviews2013161
14Fsp3: A new parameter for drug-likenessDrug Discovery Today2020156
15Recent applications of click chemistry in drug discoveryExpert Opinion on Drug Discovery2019151
16Discovery of bioactive molecules from CuAAC click-chemistry-based combinatorial librariesDrug Discovery Today2016138
17The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to ClinicJournal of Medicinal Chemistry2019124
18Strategies for the Design of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Lessons from the Development of Seven Representative ParadigmsJournal of Medicinal Chemistry2012115
19Progress in the Development of Matrix Metalloproteinase InhibitorsCurrent Medicinal Chemistry2008112
20Nanostructured lipid carriers for parenteral delivery of silybin: Biodistribution and pharmacokinetic studiesColloids and Surfaces B: Biointerfaces2010109
21Recent Development of Benzimidazole‐Containing Antibacterial AgentsChemMedChem2016108
22Overview of Recent Strategic Advances in Medicinal ChemistryJournal of Medicinal Chemistry2019108
23Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance ProfilesJournal of Medicinal Chemistry2016107
24Trend of Histone Deacetylase Inhibitors in Cancer Therapy: Isoform Selectivity or Multitargeted StrategyMedicinal Research Reviews2015106
25A gold mine for drug discovery: Strategies to develop cyclic peptides into therapiesMedicinal Research Reviews2020106
26Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer MechanismsJournal of Medicinal Chemistry2017101
27Recent Advances in Synthetic α‐Glucosidase InhibitorsChemMedChem2017100
28Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatomaBritish Journal of Cancer201599
29How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic PotentialsJournal of Chemical Information and Modeling201397
30Recent Advance in the Research of Flavonoids as Anticancer AgentsMini-Reviews in Medicinal Chemistry200793
31Design Strategies of Novel NNRTIs to Overcome Drug ResistanceCurrent Medicinal Chemistry200992
32Preparation and characterization of silybin-loaded nanostructured lipid carriersDrug Delivery201092
33Recent Advances in DAPYs and Related Analogues as HIV-1 NNRTIsCurrent Medicinal Chemistry201192
341,3,4-Oxadiazole: A Privileged Structure in Antiviral AgentsMini-Reviews in Medicinal Chemistry201190
35Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseasesEuropean Journal of Medicinal Chemistry202090
36Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in BacteriaCurrent Drug Targets201690
37Structure and Functions of Influenza Virus NeuraminidaseCurrent Medicinal Chemistry200787
38Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor ActivitiesJournal of Medicinal Chemistry201185
39Recent development of boronic acid-based fluorescent sensorsRSC Advances201884
40Medicinal chemistry strategies for discovering antivirals effective against drug-resistant virusesChemical Society Reviews202184
41Bioluminescent Probe for Hydrogen Peroxide Imaging in Vitro and in VivoAnalytical Chemistry201483
42Bioluminescence Probe for Detecting Hydrogen Sulfide in VivoAnalytical Chemistry201683
43Store-operated CRAC channel inhibitors: opportunities and challengesFuture Medicinal Chemistry201682
44New techniques and strategies in drug discoveryChinese Chemical Letters202082
45Strategies in developing promising histone deacetylase inhibitorsMedicinal Research Reviews201081
46Histone deacetylase (HDAC) inhibitors in cancer: a patent review (2017-present)Expert Opinion on Therapeutic Patents202081
47Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated VariantsJournal of Medicinal Chemistry201779
48Characterization of exosomes derived from <em>Toxoplasma gondii</em> and their functions in modulating immune responsesInternational Journal of Nanomedicine201879
49Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis SimultaneouslyJournal of Medicinal Chemistry201878
50Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple SclerosisACS Chemical Neuroscience201777