| # | Title | Journal | Year | Citations |
|---|
| 1 | Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED | JAMA - Journal of the American Medical Association | 2016 | 628 |
| 2 | Fluid Overload and Mortality in Children Receiving Continuous Renal Replacement Therapy: The Prospective Pediatric Continuous Renal Replacement Therapy Registry | American Journal of Kidney Diseases | 2010 | 576 |
| 3 | Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage | Science | 2013 | 541 |
| 4 | Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy | Journal of Allergy and Clinical Immunology | 2011 | 424 |
| 5 | Standard 6: Age Groups for Pediatric Trials | Pediatrics | 2012 | 375 |
| 6 | Postoperative Biomarkers Predict Acute Kidney Injury and Poor Outcomes after Pediatric Cardiac Surgery | Journal of the American Society of Nephrology: JASN | 2011 | 327 |
| 7 | Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells | Nature Immunology | 2016 | 305 |
| 8 | Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study | Critical Care | 2011 | 294 |
| 9 | The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress | Nature | 2014 | 292 |
| 10 | Recurrent Hypoxemia in Children Is Associated with Increased Analgesic Sensitivity to Opiates | Anesthesiology | 2006 | 286 |
| 11 | A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery | Kidney International | 2009 | 280 |
| 12 | Early emergency department treatment of acute asthma with systemic corticosteroids | The Cochrane Library | 2001 | 260 |
| 13 | Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects | | 1999 | 252 |
| 14 | Association Between Early Participation in Physical Activity Following Acute Concussion and Persistent Postconcussive Symptoms in Children and Adolescents | JAMA - Journal of the American Medical Association | 2016 | 250 |
| 15 | A Common Autoimmunity Predisposing Signal Peptide Variant of the Cytotoxic T-lymphocyte Antigen 4 Results in Inefficient Glycosylation of the Susceptibility Allele | Journal of Biological Chemistry | 2002 | 246 |
| 16 | Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial | BMJ: British Medical Journal | 2007 | 241 |
| 17 | Assessing the Diagnostic Properties of a Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children | JAMA Pediatrics | 2016 | 237 |
| 18 | miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells | Cancer Cell | 2016 | 216 |
| 19 | H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis | Nature Communications | 2019 | 215 |
| 20 | A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada | Journal of Allergy and Clinical Immunology | 2010 | 203 |
| 21 | COVID-19 and comorbidities: a systematic review and meta-analysis | Postgraduate Medicine | 2020 | 195 |
| 22 | Global seroprevalence of SARS-CoV-2 antibodies: A systematic review and meta-analysis | PLoS ONE | 2021 | 185 |
| 23 | Anaphylaxis: past, present and future | Allergy: European Journal of Allergy and Clinical Immunology | 2011 | 180 |
| 24 | Multisystem inflammatory syndrome in children and adults (MIS-C/A): Case definition & guidelines for data collection, analysis, and presentation of immunization safety data | Vaccine | 2021 | 175 |
| 25 | The Pediatric Respiratory Assessment Measure: A Valid Clinical Score for Assessing Acute Asthma Severity from Toddlers to Teenagers | Journal of Pediatrics | 2008 | 173 |
| 26 | Corticosteroids for preventing relapse following acute exacerbations of asthma | The Cochrane Library | 2007 | 166 |
| 27 | Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 2018 | 158 |
| 28 | CARD9 Deficiency and Spontaneous Central Nervous System Candidiasis: Complete Clinical Remission With GM-CSF Therapy | Clinical Infectious Diseases | 2014 | 153 |
| 29 | Epinephrine for bronchiolitis | The Cochrane Library | 2011 | 149 |
| 30 | Glucocorticoids for acute viral bronchiolitis in infants and young children | The Cochrane Library | 2013 | 148 |
| 31 | GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo | Blood | 2016 | 148 |
| 32 | Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas | Cancer Cell | 2019 | 143 |
| 33 | A New Look at Outcomes of Infants With Congenital Heart Disease | Pediatric Neurology | 2009 | 139 |
| 34 | PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism | Nature Communications | 2019 | 136 |
| 35 | Dendritic cell immunoreceptor: A novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells | Journal of Allergy and Clinical Immunology | 2014 | 131 |
| 36 | The Preschool Respiratory Assessment Measure (PRAM): A responsive index of acute asthma severity | Journal of Pediatrics | 2000 | 130 |
| 37 | High-Dose Ibuprofen in Cystic Fibrosis: Canadian Safety and Effectiveness Trial | Journal of Pediatrics | 2007 | 130 |
| 38 | Natural Progression of Symptom Change and Recovery From Concussion in a Pediatric Population | JAMA Pediatrics | 2019 | 130 |
| 39 | Prevalence of peanut allergy in primary-school children in Montreal, Canada | Journal of Allergy and Clinical Immunology | 2003 | 126 |
| 40 | SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer | Nature Communications | 2019 | 125 |
| 41 | Safety Profile of Frequent Short Courses of Oral Glucocorticoids in Acute Pediatric Asthma: Impact on Bone Metabolism, Bone Density, and Adrenal Function | Pediatrics | 2003 | 116 |
| 42 | Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas | Acta Neuropathologica | 2014 | 116 |
| 43 | Impulse Oscillometry | Chest | 2005 | 115 |
| 44 | Early postoperative serum cystatin C predicts severe acute kidney injury following pediatric cardiac surgery | Kidney International | 2011 | 114 |
| 45 | Cryopreservation of ovarian tissue and in vitro matured oocytes in a female with mosaic Turner syndrome: Case Report | Human Reproduction | 2007 | 112 |
| 46 | Kidney Outcomes 5 Years After Pediatric Cardiac Surgery | JAMA Pediatrics | 2016 | 112 |
| 47 | Four Decades of Growth Hormone Therapy for Short Children: What Have We Achieved? | Journal of Clinical Endocrinology and Metabolism | 1999 | 111 |
| 48 | Diagnostic criteria and therapeutic interventions for the hypotensive very low birth weight infant | Journal of Perinatology | 2006 | 105 |
| 49 | Risk Factors Associated With Severe Influenza Infections in Childhood: Implication for Vaccine Strategy | Pediatrics | 2003 | 103 |
| 50 | Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal | Journal of Allergy and Clinical Immunology | 2009 | 101 |
