| # | Title | Journal | Year | Citations |
|---|
| 1 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 2 | Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray | Science | 1999 | 1,434 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey | Molecular Cell | 2006 | 1,372 |
| 5 | Defining trained immunity and its role in health and disease | Nature Reviews Immunology | 2020 | 1,345 |
| 6 | Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis | Hepatology | 2017 | 1,294 |
| 7 | The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men | Nature Reviews Molecular Cell Biology | 2008 | 1,092 |
| 8 | The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights | Endocrine Reviews | 2007 | 902 |
| 9 | HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention | Oncogene | 2007 | 845 |
| 10 | BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis | Cell | 2018 | 802 |
| 11 | Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli | Lancet, The | 1999 | 663 |
| 12 | HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin | Molecular Cell | 2007 | 626 |
| 13 | Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance | Lancet Infectious Diseases, The | 2021 | 586 |
| 14 | Association Between Fibrosis Stage and Outcomes of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis | Gastroenterology | 2020 | 575 |
| 15 | A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX | Journal of Bone and Mineral Research | 2016 | 508 |
| 16 | The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases | Nucleic Acids Research | 2004 | 442 |
| 17 | Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes | Nature | 2006 | 432 |
| 18 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 19 | Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis | Gastroenterology | 2001 | 429 |
| 20 | Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy | Journal of Allergy and Clinical Immunology | 2011 | 424 |
| 21 | Olanzapine vs haloperidol: treating delirium in a critical care setting | Intensive Care Medicine | 2004 | 419 |
| 22 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 23 | Molecular Basis for the Regulation of Angiogenesis by Thrombospondin-1 and -2 | Cold Spring Harbor Perspectives in Medicine | 2012 | 398 |
| 24 | Mutation of the c-Cbl TKB Domain Binding Site on the Met Receptor Tyrosine Kinase Converts It into a Transforming Protein | Molecular Cell | 2001 | 393 |
| 25 | Validation of diagnostic codes within medical services claims | Journal of Clinical Epidemiology | 2004 | 383 |
| 26 | Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication | Molecular and Cellular Biology | 2005 | 380 |
| 27 | Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice | Kidney International | 2008 | 360 |
| 28 | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths | Science Immunology | 2021 | 357 |
| 29 | Location analysis of estrogen receptor target promoters reveals that FOXA1 defines a domain of the estrogen response | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 335 |
| 30 | Standardized definitions of structural deterioration and valve failure in assessing long-term durability of transcatheter and surgical aortic bioprosthetic valves: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) endorsed by the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) | European Heart Journal | 2017 | 335 |
| 31 | Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor α | Molecular and Cellular Biology | 2003 | 332 |
| 32 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 33 | Clinical Practice Guidelines for the Medical Management of Nonhospitalized Ulcerative Colitis: The Toronto Consensus | Gastroenterology | 2015 | 323 |
| 34 | A HUPO test sample study reveals common problems in mass spectrometry–based proteomics | Nature Methods | 2009 | 316 |
| 35 | Transgenic Mice Overexpressing Human Fibroblast Growth Factor 23 (R176Q) Delineate a Putative Role for Parathyroid Hormone in Renal Phosphate Wasting Disorders | Endocrinology | 2004 | 307 |
| 36 | Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications | Frontiers in Oncology | 2018 | 305 |
| 37 | Apolipoprotein B Particles and Cardiovascular Disease | JAMA Cardiology | 2019 | 299 |
| 38 | Cholesterol transport in steroid biosynthesis: Role of protein–protein interactions and implications in disease states | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2009 | 294 |
| 39 | Supervised and Unsupervised Self-Testing for HIV in High- and Low-Risk Populations: A Systematic Review | PLoS Medicine | 2013 | 285 |
| 40 | The experimental power of FR900359 to study Gq-regulated biological processes | Nature Communications | 2015 | 282 |
| 41 | Yield of Laboratory Testing to Identify Secondary Contributors to Osteoporosis in Otherwise Healthy Women | Journal of Clinical Endocrinology and Metabolism | 2002 | 281 |
| 42 | The role of functional social support in treatment retention and outcomes among outpatient adult substance abusers | Addiction | 2002 | 278 |
| 43 | Consensus Statements on the Risk, Prevention, and Treatment of Venous Thromboembolism in Inflammatory Bowel Disease: Canadian Association of Gastroenterology | Gastroenterology | 2014 | 277 |
| 44 | The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis | Gastroenterology | 2012 | 275 |
| 45 | Trained immunity, tolerance, priming and differentiation: distinct immunological processes | Nature Immunology | 2021 | 274 |
| 46 | Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case–control analysis | Annals of the Rheumatic Diseases | 2012 | 273 |
| 47 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 48 | Comparison of Saliva and Nasopharyngeal Swab Nucleic Acid Amplification Testing for Detection of SARS-CoV-2 | JAMA Internal Medicine | 2021 | 269 |
| 49 | Up-regulation of Wnt-1 and ?-catenin production in patients with advanced metastatic prostate carcinoma | Cancer | 2004 | 267 |
| 50 | Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis | Diabetes | 1999 | 266 |
