| # | Title | Journal | Year | Citations |
|---|
| 1 | Epigenetics in human disease and prospects for epigenetic therapy | Nature | 2004 | 2,833 |
| 2 | Architecture of the human regulatory network derived from ENCODE data | Nature | 2012 | 1,384 |
| 3 | Comprehensive analysis of CpG islands in human chromosomes 21 and 22 | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 1,294 |
| 4 | Epigenetic therapy of cancer: past, present and future | Nature Reviews Drug Discovery | 2006 | 1,139 |
| 5 | HES and HERP families: Multiple effectors of the notch signaling pathway | Journal of Cellular Physiology | 2003 | 1,099 |
| 6 | The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress | Methods | 2005 | 848 |
| 7 | Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav | Science | 1998 | 766 |
| 8 | GRP78 Induction in Cancer: Therapeutic and Prognostic Implications | Cancer Research | 2007 | 745 |
| 9 | ER chaperones in mammalian development and human diseases | FEBS Letters | 2007 | 646 |
| 10 | Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration | Nature | 2008 | 643 |
| 11 | Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts | Cell | 2008 | 623 |
| 12 | The DNA methylation paradox | Trends in Genetics | 1999 | 590 |
| 13 | Epigenetics and MicroRNAs | Pediatric Research | 2007 | 561 |
| 14 | Recent advances in craniofacial morphogenesis | Developmental Dynamics | 2006 | 535 |
| 15 | The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies | Oncogene | 2013 | 470 |
| 16 | Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression | Genome Research | 2012 | 461 |
| 17 | Endoplasmic Reticulum Stress-induced Apoptosis | Journal of Biological Chemistry | 2006 | 452 |
| 18 | Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid | Nature | 2019 | 445 |
| 19 | Two molecular pathways to transitional cell carcinoma of the bladder | Cancer Research | 1994 | 428 |
| 20 | β cell replication is the primary mechanism for maintaining postnatal β cell mass | Journal of Clinical Investigation | 2004 | 427 |
| 21 | Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 412 |
| 22 | GRP78/BiP Is Required for Cell Proliferation and Protecting the Inner Cell Mass from Apoptosis during Early Mouse Embryonic Development | Molecular and Cellular Biology | 2006 | 398 |
| 23 | Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules | Genome Research | 2012 | 381 |
| 24 | The Wnt signaling pathway in cancer | Critical Reviews in Oncology/Hematology | 2016 | 377 |
| 25 | DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons | PLoS ONE | 2007 | 375 |
| 26 | Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling | Journal of Biological Chemistry | 2002 | 361 |
| 27 | The Glucose-Regulated Proteins (GRP78 and GRP94): Functions, Gene Regulation, and Applications | Critical Reviews in Eukaryotic Gene Expression | 1994 | 354 |
| 28 | Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE) | Nucleic Acids Research | 1997 | 351 |
| 29 | Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40) | Journal of Neuroscience | 1996 | 345 |
| 30 | From The Cover: Structure of membrane-bound -synuclein studied by site-directed spin labeling | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 343 |
| 31 | Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation | Mechanisms of Development | 2001 | 335 |
| 32 | Acetylation of MyoD Directed by PCAF Is Necessary for the Execution of the Muscle Program | Molecular Cell | 1999 | 334 |
| 33 | Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines | Molecular Genetics and Metabolism | 2016 | 314 |
| 34 | Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine | Cancer Research | 2002 | 310 |
| 35 | ATF6 as a Transcription Activator of the Endoplasmic Reticulum Stress Element: Thapsigargin Stress-Induced Changes and Synergistic Interactions with NF-Y and YY1 | Molecular and Cellular Biology | 2000 | 307 |
| 36 | The Human Epigenome Browser at Washington University | Nature Methods | 2011 | 302 |
| 37 | KAP1 Protein: An Enigmatic Master Regulator of the Genome | Journal of Biological Chemistry | 2011 | 302 |
| 38 | Lck Regulates Vav Activation of Members of the Rho Family of GTPases | Molecular and Cellular Biology | 1997 | 293 |
| 39 | Probiotics and immune health | Current Opinion in Gastroenterology | 2011 | 289 |
| 40 | Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome | Epigenetics and Chromatin | 2015 | 277 |
| 41 | Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis | Carcinogenesis | 1997 | 271 |
| 42 | Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases | Molecular and Cellular Biology | 2002 | 270 |
| 43 | Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat—angiogenesis and angioma formation | Journal of the American College of Cardiology | 2000 | 267 |
| 44 | RNA CUG Repeats Sequester CUGBP1 and Alter Protein Levels and Activity of CUGBP1 | Journal of Biological Chemistry | 2001 | 266 |
| 45 | High frequency mutagenesis by a DNA methyltransferase | Cell | 1992 | 262 |
| 46 | Structure and Analysis of FCHo2 F-BAR Domain: A Dimerizing and Membrane Recruitment Module that Effects Membrane Curvature | Structure | 2007 | 261 |
| 47 | The CpG island searcher: a new WWW resource | In Silico Biology | 2003 | 260 |
| 48 | Widespread Epigenetic Abnormalities Suggest a Broad DNA Methylation Erasure Defect in Abnormal Human Sperm | PLoS ONE | 2007 | 254 |
| 49 | Lipid Membranes Modulate the Structure of Islet Amyloid Polypeptide | Biochemistry | 2005 | 252 |
| 50 | The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules | Nature Structural and Molecular Biology | 2008 | 250 |
