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Top Articles

#TitleJournalYearCitations
1Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopyChemical Society Reviews2011689
2Remaining Mysteries of Molecular Biology: The Role of Polyamines in the CellJournal of Molecular Biology2015508
3Toward interoperable bioscience dataNature Genetics2012362
4HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2Stem Cells2014226
5Cytosine DNA Methylation Is Found in Drosophila melanogaster but Absent in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Other Yeast SpeciesAnalytical Chemistry2014225
6Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperatureNature2015216
7Non‐enzymatic glycolysis and pentose phosphate pathway‐like reactions in a plausible Archean oceanMolecular Systems Biology2014182
8Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver diseaseHepatology2017138
9Functional Metabolomics Describes the Yeast Biosynthetic RegulomeCell2016137
10Metabolic profiling detects biomarkers of protein degradation in COPD patientsEuropean Respiratory Journal2012128
11Inorganic Nitrate Promotes the Browning of White Adipose Tissue Through the Nitrate-Nitrite-Nitric Oxide PathwayDiabetes2015121
12Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate MetabolismJournal of Proteome Research2016107
13The widespread role of non-enzymatic reactions in cellular metabolismCurrent Opinion in Biotechnology2015105
14The self-inhibitory nature of metabolic networks and its alleviation through compartmentalizationNature Communications201795
15Methionine Metabolism Alters Oxidative Stress Resistanceviathe Pentose Phosphate PathwayAntioxidants and Redox Signaling201693
16Sulfate radicals enable a non-enzymatic Krebs cycle precursorNature Ecology and Evolution201788
17TheSaccharomyces cerevisiaeW303-K6001 cross-platform genome sequence: insights into ancestry and physiology of a laboratory muttOpen Biology201287
18The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomicsCurrent Opinion in Chemical Biology201881
19Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase KnockoutsCell Systems201880
20The metabolic background is a global player in Saccharomyces gene expression epistasisNature Microbiology201676
21Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular CarcinomaHepatology202176
22Mitochondria in ageing: there is metabolism beyond the ROSFEMS Yeast Research201471
23Metabolomics of the interaction between PPAR‐α and age in the PPAR‐α‐null mouseMolecular Systems Biology200969
24An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of lifeBiochemical Journal201869
25The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4Journal of Molecular Biology201268
26MitoLoc: A method for the simultaneous quantification of mitochondrial network morphology and membrane potential in single cellsMitochondrion201568
27Cost-effective generation of precise label-free quantitative proteomes in high-throughput by microLC and data-independent acquisitionScientific Reports201866
28Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary OleateGastroenterology201866
29Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathwayScience Advances201665
30Dietary inorganic nitrate: From villain to hero in metabolic disease?Molecular Nutrition and Food Research201659
31Liver‐Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular CancerHepatology202157
32A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenaseNature Communications201455
33An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk FactorsJournal of Proteome Research201955
34Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidomeProceedings of the National Academy of Sciences of the United States of America201550
35Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in iceProceedings of the National Academy of Sciences of the United States of America201748
36Liquid Extraction Surface Analysis Mass Spectrometry Method for Identifying the Presence and Severity of Nonalcoholic Fatty Liver DiseaseAnalytical Chemistry201747
37N‐terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N‐end rule pathwayNew Phytologist201844
38Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptationJCI Insight201742
39FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide CycleCell202042
40A role for vaccinia virus protein C16 in reprogramming cellular energy metabolismJournal of General Virology201541
41Cell‐to‐cell heterogeneity emerges as consequence of metabolic cooperation in a synthetic yeast communityBiotechnology Journal201641
42KniMet: a pipeline for the processing of chromatography–mass spectrometry metabolomics dataMetabolomics201840
43A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty AcidsAnalytical Chemistry201940
44Italian cohort of patients affected by inflammatory bowel disease is characterised by variation in glycerophospholipid, free fatty acids and amino acid levelsMetabolomics201839
45Sacrifice for survivalNature201135
46Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid ReleaseDiabetes201735
47A gas chromatography-mass spectrometry untargeted metabolomics approach to discriminate Fiore Sardo cheese produced from raw or thermized ovine milkJournal of Dairy Science201931
48Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base CampScientific Reports201931
49Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitisNature Metabolism202031
50An Integrated Model of Transcription Factor Diffusion Shows the Importance of Intersegmental Transfer and Quaternary Protein Structure for Target Site FindingPLoS ONE201431