| # | Title | Journal | Year | Citations |
|---|
| 1 | Induction of c-fos-like protein in spinal cord neurons following sensory stimulation | Nature | 1987 | 1,912 |
| 2 | Croonian Lecture - The antidiuretic hormone and the factors which determine its release | Proceedings of the Royal Society of London Series B, Containing Papers of A Biological Character | 1947 | 888 |
| 3 | Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation | Journal of Neuroscience | 1999 | 864 |
| 4 | Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation | Journal of Molecular Biology | 1970 | 778 |
| 5 | Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission | British Journal of Pharmacology | 1971 | 717 |
| 6 | EFFECTS OF 6-HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN | Journal of Neurochemistry | 1970 | 663 |
| 7 | NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels | EMBO Journal | 2005 | 637 |
| 8 | Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival | Nature Reviews Cancer | 2008 | 600 |
| 9 | The retrograde axonal transport of nerve growth factor | Brain Research | 1974 | 598 |
| 10 | Multiple opiate receptor sites on primary afferent fibres | Nature | 1980 | 595 |
| 11 | Multidrug efflux pumps: structure, function and regulation | Nature Reviews Microbiology | 2018 | 580 |
| 12 | ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes–possible sensory mechanism? | Journal of Physiology | 1997 | 567 |
| 13 | THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEX | Journal of Neurochemistry | 1968 | 552 |
| 14 | Classification and nomenclature of somatostatin receptors | Trends in Pharmacological Sciences | 1995 | 537 |
| 15 | A proposed new nomenclature for 5-HT receptors | Trends in Pharmacological Sciences | 1993 | 534 |
| 16 | Dopamine receptors in the brain | Science | 1975 | 533 |
| 17 | Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy | Nature | 1993 | 507 |
| 18 | Secretion of a Chromaffin Granule Protein, Chromogranin, from the Adrenal Gland after Splanchnic Stimulation | Nature | 1967 | 505 |
| 19 | Tissue distribution of adenosine receptor mRNAs in the rat | British Journal of Pharmacology | 1996 | 503 |
| 20 | Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat | Science | 2017 | 503 |
| 21 | A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells | Nature | 1985 | 472 |
| 22 | Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? | Journal of Neuroinflammation | 2011 | 466 |
| 23 | Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence | Fluids and Barriers of the CNS | 2014 | 466 |
| 24 | Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide | Journal of Physiology | 2001 | 453 |
| 25 | NAADP Mobilizes Ca2+ from Reserve Granules, Lysosome-Related Organelles, in Sea Urchin Eggs | Cell | 2002 | 442 |
| 26 | PI4P and PI(4,5)P 2 Are Essential But Independent Lipid Determinants of Membrane Identity | Science | 2012 | 435 |
| 27 | Organization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains | Physiological Reviews | 2007 | 426 |
| 28 | GABA UPTAKE IN RAT CENTRAL NERVOUS SYSTEM: COMPARISON OF UPTAKE IN SLICES AND HOMOGENATES AND THE EFFECTS OF SOME INHIBITORS | Journal of Neurochemistry | 1971 | 411 |
| 29 | Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism | Nature | 1974 | 393 |
| 30 | Localisation of breast cancer resistance protein in microvessel endothelium of human brain | NeuroReport | 2002 | 390 |
| 31 | Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family | Trends in Pharmacological Sciences | 2003 | 382 |
| 32 | Spontaneous calcium release from inositol trisphosphate-sensitive calcium stores | Nature | 1991 | 376 |
| 33 | Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism | Cell Metabolism | 2008 | 369 |
| 34 | Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation | Journal of Neuroscience | 2000 | 366 |
| 35 | Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography | Brain Research | 1972 | 365 |
| 36 | Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease | Journal of Neuroscience | 2005 | 361 |
| 37 | Selective Discrimination Learning Impairments in Mice Expressing the Human Huntington's Disease Mutation | Journal of Neuroscience | 1999 | 355 |
| 38 | DOPAMINE IN THE MESOLIMBIC SYSTEM OF THE RAT BRAIN: ENDOGENOUS LEVELS AND THE EFFECTS OF DRUGS ON THE UPTAKE MECHANISM AND STIMULATION OF ADENYLATE CYCLASE ACTIVITY | Journal of Neurochemistry | 1974 | 341 |
| 39 | The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat | Brain Research | 1978 | 339 |
| 40 | CATECHOLAMINE UPTAKE PROCESSES | British Medical Bulletin | 1973 | 328 |
| 41 | Regulation and organization of adenylyl cyclases and cAMP | Biochemical Journal | 2003 | 311 |
| 42 | Post morten changes and regional distribution of substance P in the rat and mouse nervous system | Brain Research | 1976 | 310 |
| 43 | Receptors for 5-Hydroxytryptamine: Current perspectives on classification and nomenclature | Neuropharmacology | 1994 | 309 |
| 44 | Trans-synaptic regulation of growth and development of adrenergic neurones in a mouse sympathetic ganglion | Brain Research | 1971 | 308 |
| 45 | In silico patent searching reveals a new cannabinoid receptor | Trends in Pharmacological Sciences | 2006 | 302 |
| 46 | Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels | Pflugers Archiv European Journal of Physiology | 1990 | 300 |
| 47 | HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain | Science | 2011 | 297 |
| 48 | Distribution of putative neurotransmitters in the neocortex | Neuroscience | 1979 | 296 |
| 49 | Analysis of protein-ligand interactions by fluorescence polarization | Nature Protocols | 2011 | 296 |
| 50 | Reduced thermogenesis in obesity | Nature | 1979 | 292 |
