| # | Title | Journal | Year | Citations |
|---|
| 1 | The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY | Nucleic Acids Research | 2018 | 1,584 |
| 2 | Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages | Cell | 2016 | 1,396 |
| 3 | M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination | Nature Neuroscience | 2013 | 1,357 |
| 4 | The Pangenome Structure ofEscherichia coli: Comparative Genomic Analysis ofE. coliCommensal and Pathogenic Isolates | Journal of Bacteriology | 2008 | 763 |
| 5 | Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study | Lancet Infectious Diseases, The | 2011 | 751 |
| 6 | Effectiveness of isolation, testing, contact tracing, and physical distancing on reducing transmission of SARS-CoV-2 in different settings: a mathematical modelling study | Lancet Infectious Diseases, The | 2020 | 710 |
| 7 | Enhancer Evolution across 20 Mammalian Species | Cell | 2015 | 671 |
| 8 | Assembly and localization of Toll-like receptor signalling complexes | Nature Reviews Immunology | 2014 | 653 |
| 9 | Evidence for several waves of global transmission in the seventh cholera pandemic | Nature | 2011 | 649 |
| 10 | Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation | Journal of Neuroscience | 2006 | 626 |
| 11 | CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination | Cell Stem Cell | 2010 | 549 |
| 12 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study | Lancet Neurology, The | 2012 | 548 |
| 13 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? | Proceedings of the Royal Society B: Biological Sciences | 2013 | 508 |
| 14 | The evolution of seasonal influenza viruses | Nature Reviews Microbiology | 2018 | 483 |
| 15 | High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi | Nature Genetics | 2008 | 453 |
| 16 | Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis | Nature Medicine | 2014 | 451 |
| 17 | Reducing antimicrobial use in food animals | Science | 2017 | 448 |
| 18 | Global circulation patterns of seasonal influenza viruses vary with antigenic drift | Nature | 2015 | 445 |
| 19 | Producing polished prokaryotic pangenomes with the Panaroo pipeline | Genome Biology | 2020 | 419 |
| 20 | The incidence of bacterial endosymbionts in terrestrial arthropods | Proceedings of the Royal Society B: Biological Sciences | 2015 | 414 |
| 21 | Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals | PLoS ONE | 2010 | 405 |
| 22 | Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer | Pharmacological Reviews | 2009 | 387 |
| 23 | The clinical importance of emerging Campylobacter species | Nature Reviews Gastroenterology and Hepatology | 2011 | 384 |
| 24 | The emergence of mecC methicillin-resistant Staphylococcus aureus | Trends in Microbiology | 2014 | 351 |
| 25 | HyPhy 2.5—A Customizable Platform for Evolutionary Hypothesis Testing Using Phylogenies | Molecular Biology and Evolution | 2020 | 342 |
| 26 | One Health, emerging infectious diseases and wildlife: two decades of progress? | Philosophical Transactions of the Royal Society B: Biological Sciences | 2017 | 334 |
| 27 | The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system | Biomaterials | 2014 | 331 |
| 28 | Genome of Rhodnius prolixus , an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 329 |
| 29 | Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes | Nature | 2018 | 328 |
| 30 | Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System | Neuron | 2008 | 321 |
| 31 | Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts | Infection and Immunity | 2009 | 315 |
| 32 | Molecular mechanisms involved in inflammasome activation | Trends in Cell Biology | 2009 | 310 |
| 33 | Distinguishable Epidemics of Multidrug-Resistant Salmonella Typhimurium DT104 in Different Hosts | Science | 2013 | 310 |
| 34 | Viruses as vaccine vectors for infectious diseases and cancer | Nature Reviews Microbiology | 2010 | 308 |
| 35 | The molecular basis of the host response to lipopolysaccharide | Nature Reviews Microbiology | 2010 | 303 |
| 36 | Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression | Neurobiology of Disease | 2005 | 301 |
| 37 | The Evolution and Genetics of Virus Host Shifts | PLoS Pathogens | 2014 | 291 |
| 38 | Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 285 |
| 39 | Wolbachia Variants Induce Differential Protection to Viruses in Drosophila melanogaster: A Phenotypic and Phylogenomic Analysis | PLoS Genetics | 2013 | 277 |
| 40 | Mammalian karyotype evolution | Nature Reviews Genetics | 2007 | 275 |
| 41 | Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition | Nature Genetics | 2020 | 275 |
| 42 | Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells | Annals of Neurology | 2009 | 270 |
| 43 | Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes | PLoS Biology | 2013 | 264 |
| 44 | Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH) | BMC Genomics | 2009 | 253 |
| 45 | In the platypus a meiotic chain of ten sex chromosomes shares genes with the bird Z and mammal X chromosomes | Nature | 2004 | 252 |
| 46 | Effect of a serogroup A meningococcal conjugate vaccine (PsA–TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study | Lancet, The | 2014 | 230 |
| 47 | Single Protein Molecule Detection by Glass Nanopores | ACS Nano | 2013 | 228 |
| 48 | A decade of advances in transposon-insertion sequencing | Nature Reviews Genetics | 2020 | 228 |
| 49 | Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors | Nature Communications | 2015 | 223 |
| 50 | A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus | MBio | 2020 | 219 |
