| # | Title | Journal | Year | Citations |
|---|
| 1 | Protein production by auto-induction in high-density shaking cultures | Protein Expression and Purification | 2005 | 4,981 |
| 2 | Analysis of bacteriophage T7 early RNAs and proteins on slab gels | Journal of Molecular Biology | 1973 | 2,380 |
| 3 | Errors in protein structures | Nature | 1996 | 1,987 |
| 4 | Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels | Journal of Molecular Biology | 1977 | 1,735 |
| 5 | Vectors for selective expression of cloned DNAs by T7 RNA polymerase | Gene | 1987 | 1,594 |
| 6 | INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT* | Annals of the New York Academy of Sciences | 2006 | 1,532 |
| 7 | DNA-guided crystallization of colloidal nanoparticles | Nature | 2008 | 1,420 |
| 8 | The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution | Science | 2000 | 1,298 |
| 9 | "Plugging into Enzymes": Nanowiring of Redox Enzymes by a Gold Nanoparticle | Science | 2003 | 1,248 |
| 10 | KBase: The United States Department of Energy Systems Biology Knowledgebase | Nature Biotechnology | 2018 | 955 |
| 11 | Post-translational modifications and activation of p53 by genotoxic stresses | FEBS Journal | 2001 | 919 |
| 12 | p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin | Biochemical and Biophysical Research Communications | 1967 | 910 |
| 13 | Negative Regulation of Anthocyanin Biosynthesis in Arabidopsis by a miR156-Targeted SPL Transcription Factor | Plant Cell | 2011 | 804 |
| 14 | Crystal structure of globular domain of histone H5 and its implications for nucleosome binding | Nature | 1993 | 754 |
| 15 | Wavelengths effective in induction of malignant melanoma. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 667 |
| 16 | The versatility and adaptation of bacteria from the genus Stenotrophomonas | Nature Reviews Microbiology | 2009 | 641 |
| 17 | Defining the CREB RegulonA Genome-Wide Analysis of Transcription Factor Regulatory Regions | Cell | 2004 | 626 |
| 18 | Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules | Acta Crystallographica Section D: Biological Crystallography | 1998 | 613 |
| 19 | The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis | Cell | 1997 | 572 |
| 20 | Gene mapping with recombinant inbreds in maize. | Genetics | 1988 | 529 |
| 21 | Genome Survey and Characterization of Endophytic Bacteria Exhibiting a Beneficial Effect on Growth and Development of Poplar Trees | Applied and Environmental Microbiology | 2009 | 524 |
| 22 | Repair deficient human disorders and cancer | Nature | 1978 | 494 |
| 23 | A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 465 |
| 24 | Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. | Molecular and Cellular Biology | 1992 | 453 |
| 25 | Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 438 |
| 26 | Controlling basal expression in an inducible T7 expression system by blocking the target T7 promoter with lac repressor | Journal of Molecular Biology | 1991 | 419 |
| 27 | Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B | | 2000 | 415 |
| 28 | Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity | Nature Genetics | 2002 | 410 |
| 29 | Complementary specificity of restriction endonucleases of Diplococcus pneumoniae with respect to DNA methylation | Journal of Molecular Biology | 1977 | 407 |
| 30 | Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. | Molecular and Cellular Biology | 1990 | 405 |
| 31 | Structural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CAR | Science | 1999 | 400 |
| 32 | ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication | Nature | 1989 | 396 |
| 33 | Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway | Nature Genetics | 2004 | 393 |
| 34 | 3-Å resolution structure of a protein with histone-like properties in prokaryotes | Nature | 1984 | 382 |
| 35 | Crystal structure of photolysed carbonmonoxy-myoglobin | Nature | 1994 | 354 |
| 36 | A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1 | Nature | 1991 | 348 |
| 37 | Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution | Nature | 1999 | 347 |
| 38 | T7 Early RNAs and Escherichia coli Ribosomal RNAs are Cut from Large Precursor RNAs In Vivo by Ribonuclease III | Proceedings of the National Academy of Sciences of the United States of America | 1973 | 345 |
| 39 | Molecular basis for insulin fibril assembly | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 341 |
| 40 | Horizontal Gene Transfer to Endogenous Endophytic Bacteria from Poplar Improves Phytoremediation of Toluene | Applied and Environmental Microbiology | 2005 | 332 |
| 41 | Diamond family of nanoparticle superlattices | Science | 2016 | 331 |
| 42 | Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways | Molecular Cell | 2006 | 323 |
| 43 | Action spectrum for DMA damage in alfalfa lowers predicted impact of ozone depletion | Nature | 1992 | 313 |
| 44 | Structure of the regulatory domain of scallop myosin at 2.8 Ä resolution | Nature | 1994 | 313 |
| 45 | Wavelength dependence of pyrimidine dimer formation in DNA of human skin irradiated in situ with ultraviolet light. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 307 |
| 46 | Molecular fate of DNA in genetic transformation of Pneumococcus | Journal of Molecular Biology | 1962 | 303 |
| 47 | Nonspecifically bound proteins spin while diffusing along DNA | Nature Structural and Molecular Biology | 2009 | 297 |
| 48 | Relationships between mitotic cycle duration, S period duration and the average rate of DNA synthesis in the root meristem cells of several plants | Experimental Cell Research | 1965 | 294 |
| 49 | A chloroplast pathway for the de novo biosynthesis of triacylglycerol inChlamydomonas reinhardtii | FEBS Letters | 2011 | 291 |
| 50 | Genome Sequence of the Plant Growth Promoting Endophytic Bacterium Enterobacter sp. 638 | PLoS Genetics | 2010 | 282 |
