| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 2 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 3 | Blood-Brain Barrier Breakdown in the Aging Human Hippocampus | Neuron | 2015 | 1,436 |
| 4 | Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction | Nature Medicine | 2019 | 987 |
| 5 | Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases | Archives of Neurology | 2003 | 854 |
| 6 | Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group | Molecular Psychiatry | 2016 | 850 |
| 7 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 8 | Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease | Lancet Neurology, The | 2013 | 571 |
| 9 | Estrogen for Alzheimer’s disease in women | Neurology | 2000 | 551 |
| 10 | Plasticity of Hippocampal Circuitry in Alzheimer's Disease | Science | 1985 | 465 |
| 11 | Age, APOE and sex: Triad of risk of Alzheimer’s disease | Journal of Steroid Biochemistry and Molecular Biology | 2016 | 443 |
| 12 | Stroke Declines From Third to Fourth Leading Cause of Death in the United States | Stroke | 2011 | 339 |
| 13 | Homozygotes for Huntington's disease | Nature | 1987 | 331 |
| 14 | Long‐term evolution of multiple sclerosis disability in the treatment era | Annals of Neurology | 2016 | 331 |
| 15 | Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines | Journal of Experimental Medicine | 2002 | 321 |
| 16 | A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease | JAMA Neurology | 2014 | 312 |
| 17 | Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons | JAMA - Journal of the American Medical Association | 2017 | 311 |
| 18 | Retention of upper limb function in stroke survivors who have received constraint-induced movement therapy: the EXCITE randomised trial | Lancet Neurology, The | 2008 | 306 |
| 19 | Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial | Lancet, The | 2016 | 299 |
| 20 | Melanopsin retinal ganglion cell loss in Alzheimer disease | Annals of Neurology | 2016 | 299 |
| 21 | Effects of Treadmill Exercise on Dopaminergic Transmission in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Lesioned Mouse Model of Basal Ganglia Injury | Journal of Neuroscience | 2007 | 284 |
| 22 | Neuropathological basis of magnetic resonance images in aging and dementia | Annals of Neurology | 2008 | 282 |
| 23 | The insula: a critical neural substrate for craving and drug seeking under conflict and risk | Annals of the New York Academy of Sciences | 2014 | 278 |
| 24 | Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia | Journal of Neuroscience Research | 2004 | 277 |
| 25 | The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative | Nature Reviews Neurology | 2016 | 274 |
| 26 | Dorsal Premotor Cortex and Conditional Movement Selection: A PET Functional Mapping Study | Journal of Neurophysiology | 1998 | 271 |
| 27 | Neuropathologic Substrates of Ischemic Vascular Dementia | Journal of Neuropathology and Experimental Neurology | 2000 | 265 |
| 28 | Effect of estradiol on cytokine secretion by proteolipid protein-specific T cell clones isolated from multiple sclerosis patients and normal control subjects. | Journal of Immunology | 1997 | 246 |
| 29 | Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set | Alzheimer Disease and Associated Disorders | 2018 | 241 |
| 30 | Functional anatomy of human eyeblink conditioning determined with regional cerebral glucose metabolism and positron-emission tomography. | Proceedings of the National Academy of Sciences of the United States of America | 1995 | 239 |
| 31 | Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years | Multiple Sclerosis Journal | 2000 | 238 |
| 32 | Acute and Chronic Changes in Diffusivity Measures after Sports Concussion | Journal of Neurotrauma | 2011 | 238 |
| 33 | Cognitive impact of subcortical vascular and Alzheimer's disease pathology | Annals of Neurology | 2006 | 236 |
| 34 | A multicenter, prospective pilot study of gamma knife radiosurgery for mesial temporal lobe epilepsy: Seizure response, adverse events, and verbal memory | Annals of Neurology | 2009 | 236 |
| 35 | Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease | Neuroscience Letters | 1990 | 235 |
| 36 | Longitudinal MRI and cognitive change in healthy elderly. | Neuropsychology | 2007 | 233 |
| 37 | Longitudinal Changes in Memory and Executive Functioning are Associated with longitudinal change in instrumental activities of daily living in older Adults | Clinical Neuropsychologist | 2009 | 233 |
| 38 | Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis | Neurobiology of Aging | 2003 | 232 |
| 39 | A microfluidic processor for gene expression profiling of single human embryonic stem cells | Lab on A Chip | 2008 | 229 |
| 40 | How might physical activity benefit patients with Parkinson disease? | Nature Reviews Neurology | 2011 | 227 |
| 41 | Molecular mechanisms at the core of the plant circadian oscillator | Nature Structural and Molecular Biology | 2016 | 226 |
| 42 | Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis | Nature Genetics | 2017 | 226 |
| 43 | Motor Task Difficulty and Brain Activity: Investigation of Goal-Directed Reciprocal Aiming Using Positron Emission Tomography | Journal of Neurophysiology | 1997 | 212 |
| 44 | Sex-Specific Trends in Midlife Coronary Heart Disease Risk and Prevalence | Archives of Internal Medicine | 2009 | 209 |
| 45 | MGH–USC Human Connectome Project datasets with ultra-high b-value diffusion MRI | NeuroImage | 2016 | 209 |
| 46 | Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: A meta-analysis | Atherosclerosis | 2011 | 206 |
| 47 | Spatial Disorientation in Alzheimer's Disease | Archives of Neurology | 1989 | 204 |
| 48 | Longitudinal Verbal Fluency in Normal Aging, Preclinical, and Prevalent Alzheimer’s Disease | American Journal of Alzheimer's Disease and Other Dementias | 2009 | 204 |
| 49 | Effects of Task-Specific Locomotor and Strength Training in Adults Who Were Ambulatory After Stroke: Results of the STEPS Randomized Clinical Trial | Physical Therapy | 2007 | 202 |
| 50 | Breastfeeding in Children of Women Taking Antiepileptic Drugs | JAMA Pediatrics | 2014 | 201 |
