| # | Title | Journal | Year | Citations |
|---|
| 1 | Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 | Science | 2000 | 1,323 |
| 2 | Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database | Annals of the Rheumatic Diseases | 2010 | 1,017 |
| 3 | Concise Review: Adipose Tissue-Derived Stromal Cells-Basic and Clinical Implications for Novel Cell-Based Therapies | Stem Cells | 2007 | 971 |
| 4 | High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents | Obesity | 2007 | 905 |
| 5 | Synovial fibroblasts spread rheumatoid arthritis to unaffected joints | Nature Medicine | 2009 | 679 |
| 6 | Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa | Gastroenterology | 1998 | 661 |
| 7 | Defining high-fat-diet rat models: metabolic and molecular effects of different fat types | Journal of Molecular Endocrinology | 2006 | 557 |
| 8 | Molecular mechanisms of "detachment-induced apoptosis--Anoikis" | Apoptosis: an International Journal on Programmed Cell Death | 2002 | 484 |
| 9 | Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation | Gastroenterology | 2002 | 467 |
| 10 | Cytokines in Inflammatory Bowel Disease | World Journal of Surgery | 1998 | 447 |
| 11 | PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis | Journal of Hepatology | 2006 | 331 |
| 12 | Blockade of TNF-α rapidly inhibits pain responses in the central nervous system | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 308 |
| 13 | IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 300 |
| 14 | Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice | Clinical and Experimental Immunology | 1997 | 286 |
| 15 | GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis | American Journal of Pathology | 2009 | 283 |
| 16 | Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue | Biochimica Et Biophysica Acta Gene Regulatory Mechanisms | 2005 | 281 |
| 17 | Interferon-gamma (IFN-γ)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice | Clinical and Experimental Immunology | 1999 | 279 |
| 18 | Lactobacillus GG in inducing and maintaining remission of Crohn's disease | BMC Gastroenterology | 2004 | 277 |
| 19 | Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients | Journal of Lipid Research | 2003 | 275 |
| 20 | Wound healing and fibrosis in intestinal disease | Gut | 2007 | 262 |
| 21 | Development of the Lémann Index to Assess Digestive Tract Damage in Patients With Crohn's Disease | Gastroenterology | 2015 | 257 |
| 22 | Norepinephrine, the β-Adrenergic Receptor, and Immunity | Brain, Behavior, and Immunity | 2002 | 247 |
| 23 | Extraintestinal manifestations and complications in IBD | Nature Reviews Gastroenterology and Hepatology | 2013 | 247 |
| 24 | Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma | Cancer Science | 2009 | 242 |
| 25 | Role of Adipose Tissue as an Inflammatory Organ in Human Diseases | Endocrine Reviews | 2006 | 226 |
| 26 | Different effects of adiponectin isoforms in human monocytic cells | Journal of Leukocyte Biology | 2006 | 222 |
| 27 | Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs | Trends in Immunology | 2007 | 212 |
| 28 | Use of Self-Expandable Plastic Stents For the Treatment of Esophageal Perforations and Symptomatic Anastomotic Leaks | Endoscopy | 2004 | 204 |
| 29 | Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke | Cell Death and Differentiation | 2001 | 203 |
| 30 | Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results | Journal of Clinical Periodontology | 1998 | 201 |
| 31 | Mechanisms of Disease: adipocytokines and visceral adipose tissue—emerging role in nonalcoholic fatty liver disease | Nature Reviews Gastroenterology & Hepatology | 2005 | 198 |
| 32 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells | Cell Research | 2009 | 198 |
| 33 | Albumin-Based Drug Delivery as Novel Therapeutic Approach for Rheumatoid Arthritis | Journal of Immunology | 2003 | 196 |
| 34 | Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis | Hepatology | 2004 | 196 |
| 35 | Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients | Journal of Rheumatology | 1997 | 196 |
| 36 | A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease | Gastroenterology | 2003 | 195 |
| 37 | The role of the sympathetic nervous system in intestinal inflammation | Gut | 2006 | 181 |
| 38 | The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis | Laboratory Investigation | 2008 | 176 |
| 39 | Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α | PLoS ONE | 2009 | 174 |
| 40 | Strictures in Crohn’s disease are characterised by an accumulation of mast cells colocalised with laminin but not with fibronectin or vitronectin | Gut | 1999 | 168 |
| 41 | Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease | International Journal of Colorectal Disease | 2006 | 167 |
| 42 | Isolation and phenotypic characterization of colonic macrophages | Clinical and Experimental Immunology | 1998 | 164 |
| 43 | Mechanisms of Disease: adipokines and breast cancer—endocrine and paracrine mechanisms that connect adiposity and breast cancer | Nature Clinical Practice Endocrinology and Metabolism | 2007 | 161 |
| 44 | A critical role for interleukin-1 receptor accessory protein in interleukin-1 signaling | European Journal of Immunology | 1997 | 156 |
| 45 | Imbalance of the interleukin 1 system in colonic mucosa—association with intestinal inflammation and interleukin 1 receptor agonist genotype 2 | Gut | 1997 | 154 |
| 46 | In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis | Clinical and Experimental Immunology | 2007 | 141 |
| 47 | Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis | Gut | 2005 | 138 |
| 48 | C1q/TNF-Related Protein-3 Represents a Novel and Endogenous Lipopolysaccharide Antagonist of the Adipose Tissue | Endocrinology | 2010 | 137 |
| 49 | Administration of Oral Probiotic Bacteria to Pregnant Women Causes Temporary Infantile Colonization | Journal of Pediatric Gastroenterology and Nutrition | 2004 | 135 |
| 50 | Secondary sclerosing cholangitis | Nature Reviews Gastroenterology and Hepatology | 2009 | 134 |
