| # | Title | Journal | Year | Citations |
|---|
| 1 | Axonal damage in acute multiple sclerosis lesions | Brain | 1997 | 1,343 |
| 2 | Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo | Nature | 2003 | 1,187 |
| 3 | The neuropsychology of schizophrenia | Behavioral and Brain Sciences | 1991 | 1,135 |
| 4 | Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion | Clinical Chemistry | 2004 | 913 |
| 5 | Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus | Nature | 2000 | 880 |
| 6 | Salient features of synaptic organisation in the cerebral cortex1Published on the World Wide Web on 3 March 1998.1 | Brain Research Reviews | 1998 | 820 |
| 7 | Defined types of cortical interneurone structure space and spike timing in the hippocampus | Journal of Physiology | 2005 | 795 |
| 8 | Segregation of Different GABAAReceptors to Synaptic and Extrasynaptic Membranes of Cerebellar Granule Cells | Journal of Neuroscience | 1998 | 764 |
| 9 | Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus | Neuron | 1998 | 730 |
| 10 | Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium | Nature Medicine | 2008 | 730 |
| 11 | Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli | Science | 2004 | 723 |
| 12 | NAADP mobilizes calcium from acidic organelles through two-pore channels | Nature | 2009 | 687 |
| 13 | The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip | British Journal of Pharmacology | 1969 | 674 |
| 14 | Cannabis and the brain | Brain | 2003 | 666 |
| 15 | Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene | Nature Neuroscience | 2001 | 661 |
| 16 | Turnover of resident microglia in the normal adult mouse brain | Neuroscience | 1992 | 609 |
| 17 | The reorganization and reactivation of hippocampal maps predict spatial memory performance | Nature Neuroscience | 2010 | 595 |
| 18 | Lysosomal storage disorders: The cellular impact of lysosomal dysfunction | Journal of Cell Biology | 2012 | 579 |
| 19 | Lysosomal storage diseases | Nature Reviews Disease Primers | 2018 | 563 |
| 20 | The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle | British Journal of Pharmacology | 1970 | 531 |
| 21 | Secretion of a Chromaffin Granule Protein, Chromogranin, from the Adrenal Gland after Splanchnic Stimulation | Nature | 1967 | 505 |
| 22 | Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 497 |
| 23 | A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 480 |
| 24 | NAADP Mobilizes Ca2+ from Reserve Granules, Lysosome-Related Organelles, in Sea Urchin Eggs | Cell | 2002 | 442 |
| 25 | Increased number of synaptic GABAA receptors underlies potentiation at hippocampal inhibitory synapses | Nature | 1998 | 437 |
| 26 | The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen | EMBO Journal | 1997 | 416 |
| 27 | Random synaptic feedback weights support error backpropagation for deep learning | Nature Communications | 2016 | 412 |
| 28 | Synaptic connections of morphologically identified and physiologically characterized large basket cells in the striate cortex of cat | Neuroscience | 1983 | 405 |
| 29 | The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis | Neuroscience | 2000 | 400 |
| 30 | Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) | Nature Genetics | 2003 | 398 |
| 31 | Backpropagation and the brain | Nature Reviews Neuroscience | 2020 | 385 |
| 32 | Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1α, mGluR2 and mGluR5, relative to neurotransmitter release sites | Journal of Chemical Neuroanatomy | 1997 | 380 |
| 33 | A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response | Stem Cell Reports | 2017 | 379 |
| 34 | Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone | Nature | 1996 | 378 |
| 35 | Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells | Nature | 1999 | 377 |
| 36 | A third class of anti‐arrhythmic action. Effects on atrial and ventricular intracellular potentials, and other pharmacological actions on cardiac muscle, of MJ 1999 and AH 3474 | British Journal of Pharmacology | 1970 | 374 |
| 37 | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence | Nature Neuroscience | 2014 | 373 |
| 38 | Dichotomous Organization of the External Globus Pallidus | Neuron | 2012 | 367 |
| 39 | IhChannels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain | Journal of Neuroscience | 2002 | 365 |
| 40 | Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord | European Journal of Neuroscience | 1999 | 361 |
| 41 | Play it again: reactivation of waking experience and memory | Trends in Neurosciences | 2010 | 361 |
| 42 | Homocysteine, B Vitamins, and Cognitive Impairment | Annual Review of Nutrition | 2016 | 361 |
| 43 | Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide | Nature | 2007 | 359 |
| 44 | Cognitive and clinical outcomes of homocysteine‐lowering B‐vitamin treatment in mild cognitive impairment: a randomized controlled trial | International Journal of Geriatric Psychiatry | 2012 | 345 |
| 45 | Living on the edge with too many mouths to feed: Why dopamine neurons die | Movement Disorders | 2012 | 343 |
| 46 | Spike timing of dendrite-targeting bistratified cells during hippocampal network oscillations in vivo | Nature Neuroscience | 2004 | 339 |
| 47 | Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo | Neuroscience | 1998 | 329 |
| 48 | Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease | Biochemical Journal | 2011 | 329 |
| 49 | Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum | Trends in Neurosciences | 1987 | 328 |
| 50 | Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs | Science | 1993 | 318 |
