| # | Title | Journal | Year | Citations |
|---|
| 1 | Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer | Science | 1989 | 6,473 |
| 2 | Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis | Nature | 1993 | 2,507 |
| 3 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 4 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 5 | Nanoparticle biointerfacing by platelet membrane cloaking | Nature | 2015 | 1,270 |
| 6 | Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue | Journal of Clinical Apheresis | 2019 | 1,263 |
| 7 | Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer | Cancer Cell | 2003 | 982 |
| 8 | Bioassay of prostate-specific antigen (PSA) using microcantilevers | Nature Biotechnology | 2001 | 968 |
| 9 | A Big Bang model of human colorectal tumor growth | Nature Genetics | 2015 | 867 |
| 10 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 11 | GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. | Proceedings of the National Academy of Sciences of the United States of America | 1996 | 655 |
| 12 | Most Early Disseminated Cancer Cells Detected in Bone Marrow of Breast Cancer Patients Have a Putative Breast Cancer Stem Cell Phenotype | Clinical Cancer Research | 2006 | 644 |
| 13 | Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration | Nature | 2008 | 643 |
| 14 | Enteric dysbiosis associated with a mouse model of alcoholic liver disease | Hepatology | 2011 | 636 |
| 15 | A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan | Cell Metabolism | 2015 | 635 |
| 16 | Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions | Nature | 1989 | 633 |
| 17 | Membrane microfilter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells | Journal of Chromatography A | 2007 | 547 |
| 18 | Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells | PLoS ONE | 2012 | 541 |
| 19 | Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells | Journal of Immunology | 2010 | 533 |
| 20 | GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors | Molecular and Cellular Biology | 1997 | 524 |
| 21 | Gene expression changes in the course of normal brain aging are sexually dimorphic | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 520 |
| 22 | MRI detects myocardial iron in the human heart | Magnetic Resonance in Medicine | 2006 | 509 |
| 23 | EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts | Nature Genetics | 1993 | 483 |
| 24 | Quantification of immunohistochemistry?issues concerning methods, utility and semiquantitative assessment II | Histopathology | 2006 | 473 |
| 25 | FCGR2A and FCGR3A Polymorphisms Associated With Clinical Outcome of Epidermal Growth Factor Receptor–Expressing Metastatic Colorectal Cancer Patients Treated With Single-Agent Cetuximab | Journal of Clinical Oncology | 2007 | 466 |
| 26 | Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease | Journal of Cerebral Blood Flow and Metabolism | 2016 | 464 |
| 27 | Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues | Oncogene | 1990 | 445 |
| 28 | Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis | Nature Genetics | 1997 | 444 |
| 29 | Antimicrobial Susceptibility Testing, Drug Resistance Mechanisms, and Therapy of Infections with Nontuberculous Mycobacteria | Clinical Microbiology Reviews | 2012 | 423 |
| 30 | Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1 | Current Biology | 2001 | 392 |
| 31 | Role of Protein Methylation in Regulation of Transcription | Endocrine Reviews | 2005 | 392 |
| 32 | The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas | Cancer Research | 2007 | 392 |
| 33 | Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas | Nature Genetics | 1999 | 383 |
| 34 | Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities | Molecular Endocrinology | 1998 | 379 |
| 35 | Evaluation of HER-2/neu Gene Amplification and Overexpression: Comparison of Frequently Used Assay Methods in a Molecularly Characterized Cohort of Breast Cancer Specimens | Journal of Clinical Oncology | 2002 | 376 |
| 36 | Genome-wide association studies identify four ER negative–specific breast cancer risk loci | Nature Genetics | 2013 | 374 |
| 37 | PTEN: Tumor Suppressor and Metabolic Regulator | Frontiers in Endocrinology | 2018 | 365 |
| 38 | Local Inhibitory Action of BMPs and Their Relationships with Activators in Feather Formation: Implications for Periodic Patterning | Developmental Biology | 1998 | 362 |
| 39 | Current concepts in the pathogenesis of alcoholic liver injury | FASEB Journal | 2001 | 343 |
| 40 | Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation | Mechanisms of Development | 2001 | 335 |
| 41 | Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance | Nature Neuroscience | 2015 | 334 |
| 42 | Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair | Nature Genetics | 1998 | 332 |
| 43 | The cell of origin of ovarian epithelial tumours | Lancet Oncology, The | 2008 | 323 |
| 44 | Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection | EMBO Journal | 2001 | 313 |
| 45 | Molecular Pathogenesis of Chronic Wounds | American Journal of Pathology | 2005 | 312 |
| 46 | Synergistic Enhancement of Nuclear Receptor Function by p160 Coactivators and Two Coactivators with Protein Methyltransferase Activities | Journal of Biological Chemistry | 2001 | 311 |
| 47 | p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction | Molecular and Cellular Biology | 2003 | 304 |
| 48 | Classifying the evolutionary and ecological features of neoplasms | Nature Reviews Cancer | 2017 | 303 |
| 49 | Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats | Gastroenterology | 2012 | 295 |
| 50 | Peroxisome Proliferator-activated Receptor γ Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells | Journal of Biological Chemistry | 2004 | 290 |
