| # | Title | Journal | Year | Citations |
|---|
| 1 | Antibiotic resistance—the need for global solutions | Lancet Infectious Diseases, The | 2013 | 3,184 |
| 2 | Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis | PLoS ONE | 2016 | 2,336 |
| 3 | Innate lymphoid cells — a proposal for uniform nomenclature | Nature Reviews Immunology | 2013 | 2,054 |
| 4 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 5 | Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family | Cell | 2012 | 1,368 |
| 6 | Association study designs for complex diseases | Nature Reviews Genetics | 2001 | 1,247 |
| 7 | Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus | Journal of Experimental Medicine | 2000 | 1,165 |
| 8 | Epigenetic protein families: a new frontier for drug discovery | Nature Reviews Drug Discovery | 2012 | 1,161 |
| 9 | Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS | Nature Medicine | 1997 | 1,096 |
| 10 | Targeting bromodomains: epigenetic readers of lysine acetylation | Nature Reviews Drug Discovery | 2014 | 1,044 |
| 11 | Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology | Nature | 2010 | 978 |
| 12 | The alarmin IL-33 promotes regulatory T-cell function in the intestine | Nature | 2014 | 846 |
| 13 | Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial | Lancet, The | 2010 | 809 |
| 14 | PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection | Journal of Experimental Medicine | 2006 | 808 |
| 15 | Evidence-based medicine | Seminars in Perinatology | 1997 | 804 |
| 16 | A genome-wide search for quantitative trait loci underlying asthma | Nature | 1996 | 750 |
| 17 | A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16 | Nature | 1985 | 718 |
| 18 | Fatty Acids, Obesity, and Insulin Resistance: Time for a Reevaluation | Diabetes | 2011 | 692 |
| 19 | HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome | Nature Genetics | 2002 | 686 |
| 20 | Transforming clinical microbiology with bacterial genome sequencing | Nature Reviews Genetics | 2012 | 684 |
| 21 | European evidence based consensus for endoscopy in inflammatory bowel disease | Journal of Crohn's and Colitis | 2013 | 679 |
| 22 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 23 | Snake bite | Lancet, The | 2010 | 637 |
| 24 | Snakebite envenoming | Nature Reviews Disease Primers | 2017 | 608 |
| 25 | The Interaction Properties of Costimulatory Molecules Revisited | Immunity | 2002 | 587 |
| 26 | Mother-to-child transmission of HIV-1 infection during exclusive breastfeeding in the first 6 months of life: an intervention cohort study | Lancet, The | 2007 | 579 |
| 27 | Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak | Lancet, The | 2003 | 578 |
| 28 | Virulent Combinations of Adhesin and Toxin Genes in Natural Populations of Staphylococcus aureus | Infection and Immunity | 2002 | 539 |
| 29 | Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial | Lancet, The | 1999 | 529 |
| 30 | GATA3 haplo-insufficiency causes human HDR syndrome | Nature | 2000 | 516 |
| 31 | Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma | Nature Communications | 2014 | 503 |
| 32 | A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci | Nature Genetics | 2010 | 493 |
| 33 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array | Nature Genetics | 2013 | 492 |
| 34 | The kinetic-segregation model: TCR triggering and beyond | Nature Immunology | 2006 | 470 |
| 35 | Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants | Nature | 1994 | 438 |
| 36 | Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses | Nature | 2001 | 438 |
| 37 | MAIT cells are activated during human viral infections | Nature Communications | 2016 | 428 |
| 38 | Copper is required for oncogenic BRAF signalling and tumorigenesis | Nature | 2014 | 425 |
| 39 | Memory Inflation: Continuous Accumulation of Antiviral CD8+ T Cells Over Time | Journal of Immunology | 2003 | 422 |
| 40 | Rapid Detection of Mycobacterium tuberculosisInfection by Enumeration of Antigen-specific T Cells | American Journal of Respiratory and Critical Care Medicine | 2001 | 410 |
| 41 | Cancer stem cells versus phenotype‐switching in melanoma | Pigment Cell and Melanoma Research | 2010 | 408 |
| 42 | Arginine methylation regulates the p53 response | Nature Cell Biology | 2008 | 405 |
| 43 | Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events | Nature Genetics | 2015 | 403 |
| 44 | Multilocus Sequence Typing of Clostridium difficile | Journal of Clinical Microbiology | 2010 | 399 |
| 45 | Downregulation of Adipose Tissue Fatty Acid Trafficking in Obesity | Diabetes | 2011 | 397 |
| 46 | MECHANISM OF EOSINOPHILIA | Journal of Experimental Medicine | 1970 | 394 |
| 47 | The structure and ligand interactions of CD2: implications for T-cell function | Trends in Immunology | 1996 | 394 |
| 48 | RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 391 |
| 49 | Phenotypic properties of transmitted founder HIV-1 | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 379 |
| 50 | Genome-wide association studies identify four ER negative–specific breast cancer risk loci | Nature Genetics | 2013 | 374 |
