| # | Title | Journal | Year | Citations |
|---|
| 1 | Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK | Lancet, The | 2021 | 3,887 |
| 2 | Guidance for conducting systematic scoping reviews | International Journal of Evidence-Based Healthcare | 2015 | 3,820 |
| 3 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,776 |
| 4 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 5 | Updated methodological guidance for the conduct of scoping reviews | JBI Evidence Synthesis | 2020 | 1,717 |
| 6 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 7 | Detection of a SARS-CoV-2 variant of concern in South Africa | Nature | 2021 | 1,381 |
| 8 | Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa | Nature | 2022 | 1,210 |
| 9 | Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials | Lancet, The | 2021 | 979 |
| 10 | Associations of linear growth and relative weight gain during early life with adult health and human capital in countries of low and middle income: findings from five birth cohort studies | Lancet, The | 2013 | 970 |
| 11 | Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium | Lancet Infectious Diseases, The | 2019 | 970 |
| 12 | World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis | PLoS Medicine | 2015 | 937 |
| 13 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 | Critical Care Medicine | 2021 | 927 |
| 14 | Neuropathic pain: an updated grading system for research and clinical practice | Pain | 2016 | 824 |
| 15 | A Practical Clinical Approach to Diagnosis of Fetal Alcohol Spectrum Disorders: Clarification of the 1996 Institute of Medicine Criteria | Pediatrics | 2005 | 779 |
| 16 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 776 |
| 17 | PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 615 |
| 18 | Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 609 |
| 19 | What we know about primary dysmenorrhea today: a critical review | Human Reproduction Update | 2015 | 525 |
| 20 | The UCL–Lancet Commission on Migration and Health: the health of a world on the move | Lancet, The | 2018 | 511 |
| 21 | The Novel Coronavirus 2019 epidemic and kidneys | Kidney International | 2020 | 502 |
| 22 | Runs of homozygosity: windows into population history and trait architecture | Nature Reviews Genetics | 2018 | 497 |
| 23 | A global map of dominant malaria vectors | Parasites and Vectors | 2012 | 485 |
| 24 | A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications | Journal of Nanomaterials | 2013 | 480 |
| 25 | Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer | Annals of Oncology | 2014 | 462 |
| 26 | Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa | Nature Medicine | 2022 | 456 |
| 27 | Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis | Lancet, The | 2022 | 445 |
| 28 | Updated methodological guidance for the conduct of scoping reviews | JBI Evidence Implementation | 2021 | 430 |
| 29 | Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial | Lancet Infectious Diseases, The | 2014 | 423 |
| 30 | Evinacumab for Homozygous Familial Hypercholesterolemia | New England Journal of Medicine | 2020 | 413 |
| 31 | Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care | Kidney International | 2015 | 407 |
| 32 | Sleep Problems: An Emerging Global Epidemic? Findings From the INDEPTH WHO-SAGE Study Among More Than 40,000 Older Adults From 8 Countries Across Africa and Asia | Sleep | 2012 | 404 |
| 33 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study | Lancet Oncology, The | 2014 | 384 |
| 34 | Changes in the worldwide epidemiology of peritoneal dialysis | Nature Reviews Nephrology | 2017 | 384 |
| 35 | A review of the chemical modification techniques of starch | Carbohydrate Polymers | 2017 | 381 |
| 36 | Genotypes and Genetic Variability of Hepatitis B Virus | Intervirology | 2014 | 368 |
| 37 | Averting a malaria disaster: will insecticide resistance derail malaria control? | Lancet, The | 2016 | 366 |
| 38 | The power of genetic diversity in genome-wide association studies of lipids | Nature | 2021 | 353 |
| 39 | Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago | Science | 2017 | 351 |
| 40 | Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children | Clinical Infectious Diseases | 2017 | 348 |
| 41 | An Evidence‐Based Approach to Scoping Reviews | Worldviews on Evidence-Based Nursing | 2016 | 340 |
| 42 | Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance | Antimicrobial Agents and Chemotherapy | 2012 | 338 |
| 43 | Life Expectancies of South African Adults Starting Antiretroviral Treatment: Collaborative Analysis of Cohort Studies | PLoS Medicine | 2013 | 330 |
| 44 | Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel | Lancet Diabetes and Endocrinology,the | 2016 | 329 |
| 45 | Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses | Clinical Infectious Diseases | 2017 | 329 |
| 46 | Sixteen novel lineages of SARS-CoV-2 in South Africa | Nature Medicine | 2021 | 326 |
| 47 | Reduction in Lipoprotein(a) With PCSK9 Monoclonal Antibody Evolocumab (AMG 145) | Journal of the American College of Cardiology | 2014 | 316 |
| 48 | Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation | International Journal of Cardiology | 2014 | 316 |
| 49 | Current advances in the fabrication of microneedles for transdermal delivery | Journal of Controlled Release | 2014 | 301 |
| 50 | Assessing the impact of mHealth interventions in low- and middle-income countries – what has been shown to work? | Global Health Action | 2014 | 288 |
