| # | Title | Journal | Year | Citations |
|---|
| 1 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study | Lancet Oncology, The | 2011 | 3,758 |
| 4 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis | Cell Research | 2015 | 1,777 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 6 | Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy | Cell | 2017 | 1,377 |
| 7 | Hydrophilic Cu9S5 Nanocrystals: A Photothermal Agent with a 25.7% Heat Conversion Efficiency for Photothermal Ablation of Cancer Cells in Vivo | ACS Nano | 2011 | 1,155 |
| 8 | Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation | Immunity | 2011 | 887 |
| 9 | Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia | European Journal of Vascular and Endovascular Surgery | 2019 | 741 |
| 10 | COVID-19 with Different Severities: A Multicenter Study of Clinical Features | American Journal of Respiratory and Critical Care Medicine | 2020 | 690 |
| 11 | Pollution and health: a progress update | Lancet Planetary Health, The | 2022 | 548 |
| 12 | Genome-wide association study identifies susceptibility loci for IgA nephropathy | Nature Genetics | 2011 | 528 |
| 13 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update | Hepatology International | 2019 | 483 |
| 14 | Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes | Cell Stem Cell | 2014 | 459 |
| 15 | Perinatal depressive and anxiety symptoms of pregnant women during the coronavirus disease 2019 outbreak in China | American Journal of Obstetrics and Gynecology | 2020 | 438 |
| 16 | Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial | Lancet Oncology, The | 2014 | 434 |
| 17 | Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21 | Nature Genetics | 2009 | 410 |
| 18 | A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients | Journal of Ovarian Research | 2014 | 397 |
| 19 | METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer | Molecular Cancer | 2019 | 389 |
| 20 | A Facile One‐Pot Synthesis of a Two‐Dimensional MoS2/Bi2S3 Composite Theranostic Nanosystem for Multi‐Modality Tumor Imaging and Therapy | Advanced Materials | 2015 | 385 |
| 21 | Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors | Biomaterials | 2015 | 362 |
| 22 | Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer | Journal of Hematology and Oncology | 2020 | 359 |
| 23 | PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation | Redox Biology | 2019 | 356 |
| 24 | Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveys | Epidemiology and Psychiatric Sciences | 2015 | 355 |
| 25 | Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride | Cell Metabolism | 2015 | 353 |
| 26 | Lanosterol reverses protein aggregation in cataracts | Nature | 2015 | 351 |
| 27 | Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium | International Journal of Cardiology | 2015 | 350 |
| 28 | Complex silica composite nanomaterials templated with DNA origami | Nature | 2018 | 346 |
| 29 | Incidence and Etiology of Drug-Induced Liver Injury in Mainland China | Gastroenterology | 2019 | 346 |
| 30 | Interventions to reduce unnecessary caesarean sections in healthy women and babies | Lancet, The | 2018 | 345 |
| 31 | Vascularized 3D printed scaffolds for promoting bone regeneration | Biomaterials | 2019 | 345 |
| 32 | Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders | ACS Nano | 2019 | 341 |
| 33 | LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern | Cancer Discovery | 2016 | 339 |
| 34 | METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST | Molecular Cancer | 2020 | 336 |
| 35 | Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy | Gut | 2018 | 330 |
| 36 | CUMULATIVE TRAUMAS AND RISK THRESHOLDS: 12-MONTH PTSD IN THE WORLD MENTAL HEALTH (WMH) SURVEYS | Depression and Anxiety | 2014 | 329 |
| 37 | Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment | Frontiers in Immunology | 2020 | 328 |
| 38 | Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score | Frontiers in Microbiology | 2019 | 326 |
| 39 | Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial | Lancet, The | 2019 | 323 |
| 40 | Acute kidney injury in China: a cross-sectional survey | Lancet, The | 2015 | 319 |
| 41 | Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis | Molecular Cell | 2016 | 319 |
| 42 | Treatment gap for anxiety disorders is global: Results of the World Mental Health Surveys in 21 countries | Depression and Anxiety | 2018 | 318 |
| 43 | Lactate dehydrogenase a in cancer: A promising target for diagnosis and therapy | IUBMB Life | 2013 | 317 |
| 44 | Enhanced osteoporotic bone regeneration by strontium-substituted calcium silicate bioactive ceramics | Biomaterials | 2013 | 311 |
| 45 | Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population | International Journal of Oral and Maxillofacial Surgery | 2010 | 307 |
| 46 | Child and Adolescent Health From 1990 to 2015 | JAMA Pediatrics | 2017 | 306 |
| 47 | Biocompatible PEGylated MoS2 nanosheets: Controllable bottom-up synthesis and highly efficient photothermal regression of tumor | Biomaterials | 2015 | 304 |
| 48 | M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124 | Theranostics | 2019 | 301 |
| 49 | DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury | Nature Biomedical Engineering | 2018 | 297 |
| 50 | Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein | Analytical Chemistry | 2020 | 296 |
