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Top Articles

#TitleJournalYearCitations
1AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterationsBlood2009318
2DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implicationsBlood2012211
3Human TLR3 recognizes dengue virus and modulates viral replicationin vitroCellular Microbiology2009182
4Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and ProgressionCell2020178
5WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring systemBlood2010156
6Enterovirus-Induced miR-141 Contributes to Shutoff of Host Protein Translation by Targeting the Translation Initiation Factor eIF4ECell Host and Microbe2011148
7ALDH-positive lung cancer stem cells confer resistance to epidermal growth factor receptor tyrosine kinase inhibitorsCancer Letters2013135
8Reticulon 3 Binds the 2C Protein of Enterovirus 71 and Is Required for Viral ReplicationJournal of Biological Chemistry2007131
9TP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolutionBlood Cancer Journal2015130
10Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferonNature Communications2014128
11Impaired phosphorylation of Na + -K + -2Cl − cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndromeProceedings of the National Academy of Sciences of the United States of America2011122
12Genetic alterations and their clinical implications in older patients with acute myeloid leukemiaLeukemia2016118
13Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet SyndromeEBioMedicine2016116
14The immunobiology of Henoch–Schönlein purpuraAutoimmunity Reviews2008114
15When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistanceCancer Communications2018107
16Sorafenib relieves cell‐intrinsic and cell‐extrinsic inhibitions of effector T cells in tumor microenvironment to augment antitumor immunityInternational Journal of Cancer2014102
17Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathwayJournal of Experimental and Clinical Cancer Research2017101
18Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib TherapyPLoS ONE201195
19Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestryBlood201790
20Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemiaLeukemia201487
21Innate immunity and primary biliary cirrhosis: Activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosisHepatology201186
22Antiviral activities of niclosamide and nitazoxanide against chikungunya virus entry and transmissionAntiviral Research201686
23The origin and underlying driving forces of the SARS-CoV-2 outbreakJournal of Biomedical Science202082
24Regression-Based Association Analysis with Clustered Haplotypes through Use of GenotypesAmerican Journal of Human Genetics200679
25Induction of DNA Damage-Inducible Gene GADD45β Contributes to Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma CellsCancer Research201076
26Houttuynia cordata Targets the Beginning Stage of Herpes Simplex Virus InfectionPLoS ONE201568
27Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndromeBlood Cancer Journal201868
28Cost-effectiveness analysis for determining optimal cut-off of immunochemical faecal occult blood test for population-based colorectal cancer screening (KCIS 16)Journal of Medical Screening200766
29Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITDLeukemia200864
30Circulating Programmed Death-1 as a Marker for Sustained High Hepatitis B Viral Load and Risk of Hepatocellular CarcinomaPLoS ONE201464
31Dynamic Plasma EGFR Mutation Status as a Predictor of EGFR-TKI Efficacy in Patients with EGFR-Mutant Lung AdenocarcinomaJournal of Thoracic Oncology201564
32Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathwayScientific Reports201764
33IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancerOncotarget201562
34Experimental Evolution of Yeast for High-Temperature ToleranceMolecular Biology and Evolution201861
35Antivirals and vaccines for Enterovirus A71Journal of Biomedical Science201961
36Suramin Inhibits Chikungunya Virus Entry and TransmissionPLoS ONE201560
37Coexistence of EGFR T790M mutation and common activating mutations in pretreatment non-small cell lung cancer: A systematic review and meta-analysisLung Cancer201660
38High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naïve advanced EGFR-mutant lung adenocarcinoma patientsLung Cancer201960
39miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cellsBreast Cancer Research201158
40H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer MetastasisCancer Research201458
41EGFR mutation, smoking, and gender in advanced lung adenocarcinomaOncotarget201758
42Upregulation of microRNA-137 expression by Slug promotes tumor invasion and metastasis of non-small cell lung cancer cells through suppression of TFAP2CCancer Letters201757
43Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146bNature Communications201857
44EnterohaemorrhagicEscherichia coli O157:H7 Shiga-like toxin 1 is required for full pathogenicity and activation of the p38 mitogen-activated protein kinase pathway inCaenorhabditis elegansCellular Microbiology201356
45Chemokine receptor expression profiles in nasopharyngeal carcinoma and their association with metastasis and radiotherapyJournal of Pathology200655
46Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemiaLeukemia Research200855
47IKZF1 deletions predict a poor prognosis in children with B‐cell progenitor acute lymphoblastic leukemia: A multicenter analysis in TaiwanCancer Science201155
48Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6EBioMedicine201655
49Compact optical diagnostic device for isothermal nucleic acids amplificationSensors and Actuators B: Chemical200853
50A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemiasLeukemia200652