| # | Title | Journal | Year | Citations |
|---|
| 1 | TOR Signaling in Growth and Metabolism | Cell | 2006 | 5,202 |
| 2 | Tissue-specific in vitro transcription from the mouse albumin promoter | Cell | 1986 | 1,361 |
| 3 | A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling | Cell | 2006 | 1,074 |
| 4 | Nucleocytoplasmic transport: signals, mechanisms and regulation | Nature | 1997 | 983 |
| 5 | Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 | PLoS Biology | 2009 | 973 |
| 6 | Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo | Cell | 1995 | 875 |
| 7 | Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics | Science | 2011 | 846 |
| 8 | Light Signal Transduction in Higher Plants | Annual Review of Genetics | 2004 | 843 |
| 9 | Interposon mutagenesis of soil and water bacteria: a family of DNA fragments designed for in vitro insertional mutagenesis of Gram-negative bacteria | Gene | 1987 | 734 |
| 10 | Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae | Molecular Cell | 2007 | 723 |
| 11 | Molecular Genetics of the Bithorax Complex in Drosophila melanogaster | Science | 1983 | 716 |
| 12 | A Web of Circadian Pacemakers | Cell | 2002 | 669 |
| 13 | DNA Replication Stress as a Hallmark of Cancer | Annual Review of Pathology: Mechanisms of Disease | 2015 | 593 |
| 14 | System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock | PLoS Biology | 2007 | 584 |
| 15 | LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. | Genes and Development | 1990 | 571 |
| 16 | The interplay of DNA-binding proteins on the promoter of the mouse albumin gene | Cell | 1987 | 567 |
| 17 | The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus | EMBO Journal | 1997 | 557 |
| 18 | Circadian Rhythms: Mechanisms and Therapeutic Implications | Annual Review of Pharmacology and Toxicology | 2007 | 552 |
| 19 | Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair | Cell | 2004 | 538 |
| 20 | TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus | Molecular Cell | 1998 | 532 |
| 21 | Peripheral Circadian Oscillators in Mammals: Time and Food | Journal of Biological Rhythms | 2003 | 470 |
| 22 | The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification | Cell Metabolism | 2006 | 454 |
| 23 | Copurification of E. coli RNAase E and PNPase: Evidence for a specific association between two enzymes important in RNA processing and degradation | Cell | 1994 | 434 |
| 24 | Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A | Nature Cell Biology | 1999 | 431 |
| 25 | Polo-like kinase-1 is a target of the DNA damage checkpoint | Nature Cell Biology | 2000 | 431 |
| 26 | Chromosome Dynamics in the Yeast Interphase Nucleus | Science | 2001 | 431 |
| 27 | DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally | Cell | 1990 | 425 |
| 28 | C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2 | Journal of Cell Biology | 1998 | 398 |
| 29 | The Vam6 GEF Controls TORC1 by Activating the EGO Complex | Molecular Cell | 2009 | 398 |
| 30 | Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells | Science | 2014 | 387 |
| 31 | A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators | EMBO Journal | 1998 | 370 |
| 32 | Regulation of m6A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline | Molecular Cell | 2017 | 370 |
| 33 | Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma | Nature Genetics | 2012 | 369 |
| 34 | REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis | PLoS Biology | 2009 | 368 |
| 35 | Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast | Nature | 1999 | 364 |
| 36 | The argininosuccinate lyase gene of Chlamydomonas reinhardtii: an important tool for nuclear transformation and for correlating the genetic and molecular maps of the ARG7 locus. | EMBO Journal | 1989 | 363 |
| 37 | Integration of microRNA miR-122 in hepatic circadian gene expression | Genes and Development | 2009 | 349 |
| 38 | CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 344 |
| 39 | Identification of a tRNA-Specific Nuclear Export Receptor | Molecular Cell | 1998 | 342 |
| 40 | The mammalian circadian timing system: from gene expression to physiology | Chromosoma | 2004 | 316 |
| 41 | Poly(ADP-Ribose) Polymerase 1 Participates in the Phase Entrainment of Circadian Clocks to Feeding | Cell | 2010 | 309 |
| 42 | Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis | Genes and Development | 2009 | 306 |
| 43 | Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis | Nature Cell Biology | 2012 | 303 |
| 44 | Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress | Nature | 2018 | 303 |
| 45 | DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1 | EMBO Journal | 2003 | 301 |
| 46 | Visualizing Chromatin Dynamics in Interphase Nuclei | Science | 2002 | 300 |
| 47 | The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates | Rna | 2000 | 298 |
| 48 | The Period Length of Fibroblast Circadian Gene Expression Varies Widely among Human Individuals | PLoS Biology | 2005 | 277 |
| 49 | Phosphoproteomic Analysis Reveals Interconnected System-Wide Responses to Perturbations of Kinases and Phosphatases in Yeast | Science Signaling | 2010 | 277 |
| 50 | Live Imaging of Telomeres | Current Biology | 2002 | 276 |
