| # | Title | Journal | Year | Citations |
|---|
| 1 | Involvement of p38 mitogen‐activated protein kinase in lipopolysaccharide‐induced iNOS and COX‐2 expression in J774 macrophages | Immunology | 1999 | 223 |
| 2 | Molecular modeling of flavonoids that inhibits xanthine oxidase | Biochemical and Biophysical Research Communications | 2002 | 220 |
| 3 | HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new target site for drugs | Protein Science | 2004 | 217 |
| 4 | Inhibitory effects of flavonoids on xanthine oxidase | Anticancer Research | 1993 | 181 |
| 5 | Structure–activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities | Biochemical Pharmacology | 2008 | 166 |
| 6 | YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia | Oncogene | 2007 | 165 |
| 7 | High-dose Dual Therapy Is Superior to Standard First-line or Rescue Therapy for Helicobacter pylori Infection | Clinical Gastroenterology and Hepatology | 2015 | 158 |
| 8 | Accelerated Clearance of Polyethylene Glycol-Modified Proteins by Anti-Polyethylene Glycol IgM | Bioconjugate Chemistry | 1999 | 137 |
| 9 | Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection | Proceedings of the National Academy of Sciences of the United States of America | 2021 | 136 |
| 10 | Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures | Plant Cell Reports | 1992 | 133 |
| 11 | New Steroid Acids from Antrodia cinnamomea, a Fungal Parasite of Cinnamomum micranthum | Journal of Natural Products | 1995 | 132 |
| 12 | Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats | Life Sciences | 2007 | 131 |
| 13 | Analysis of heat-shock protein�70 gene polymorphisms and the risk of Parkinson?s disease | Human Genetics | 2004 | 129 |
| 14 | Determinants of Adherence to Methylphenidate and the Impact of Poor Adherence on Maternal and Family Measures | Journal of Child and Adolescent Psychopharmacology | 2006 | 128 |
| 15 | ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5 | Cancer Cell | 2016 | 125 |
| 16 | Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix | Antiviral Research | 1995 | 124 |
| 17 | Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult | Biochemical Pharmacology | 2007 | 121 |
| 18 | Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways | Biochemical Pharmacology | 2010 | 119 |
| 19 | Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran | Food Chemistry | 2011 | 115 |
| 20 | Investigation of anticancer mechanism of thiadiazole-based compound in human non-small cell lung cancer A549 cells | Biochemical Pharmacology | 2003 | 114 |
| 21 | Inhibitory effects of phenolics on xanthine oxidase | Anticancer Research | 1994 | 114 |
| 22 | Stability and release performance of a series of pegylated copolymeric micelles | Pharmaceutical Research | 2003 | 112 |
| 23 | Intervertebral disc regeneration in an ex vivo culture system using mesenchymal stem cells and platelet-rich plasma | Biomaterials | 2009 | 109 |
| 24 | The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity | International Journal of Obesity | 2015 | 107 |
| 25 | Application of polymeric nanoparticles and micelles in insulin oral delivery | Journal of Food and Drug Analysis | 2015 | 105 |
| 26 | Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells | Biochemical Pharmacology | 2004 | 103 |
| 27 | Studies on Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides. 8. Synthesis and Pharmacological Evaluation of Tricyclic Fused Quinazolines and 1,2,4-Benzothiadiazine 1,1-Dioxides as Potential α1-Adrenoceptor Antagonists | Journal of Medicinal Chemistry | 1998 | 100 |
| 28 | α-Glucosidase inhibitors from the seeds of Syagrus romanzoffiana | Phytochemistry | 2008 | 98 |
| 29 | Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood‐brain barrier and MPTP‐induced dopaminergic toxicity in rodents | Journal of Neurochemistry | 2010 | 98 |
| 30 | Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain | Nature Communications | 2016 | 97 |
| 31 | Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples | Journal of Food and Drug Analysis | 2020 | 96 |
| 32 | Determining estrogens using surface-assisted laser desorption/ionization mass spectrometry with silver nanoparticles as the matrix | Journal of the American Society for Mass Spectrometry | 2008 | 95 |
| 33 | Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study | Nature Communications | 2015 | 93 |
| 34 | Hyaluronidases, a group of glycosidases: Current and future perspectives | Carbohydrate Polymers | 2010 | 91 |
| 35 | Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator | Journal of Biological Chemistry | 2011 | 91 |
| 36 | Association of Fecal and Plasma Levels of Short-Chain Fatty Acids With Gut Microbiota and Clinical Severity in Patients With Parkinson Disease | Neurology | 2022 | 90 |
| 37 | Nucleosides: XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs | Chemical and Pharmaceutical Bulletin | 2004 | 88 |
| 38 | Electrophoretic behavior and pKa determination of quinolones with a piperazinyl substituent by capillary zone electrophoresis | Journal of Chromatography A | 2004 | 88 |
| 39 | Alisol B acetate, a triterpene from Alismatis rhizoma, induces Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells | Cancer Letters | 2006 | 88 |
| 40 | Quinazolin-4-one Derivatives as Selective Histone Deacetylase-6 Inhibitors for the Treatment of Alzheimer’s Disease | Journal of Medicinal Chemistry | 2013 | 87 |
| 41 | Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes | Osteoarthritis and Cartilage | 2013 | 87 |
| 42 | Steroids and triterpenoids of Antodia cinnamomea—A fungus parasitic on Cinnamomum micranthum | Phytochemistry | 1996 | 84 |
| 43 | Acylated flavonol monorhamnosides, α-glucosidase inhibitors, from Machilus philippinensis | Phytochemistry | 2008 | 84 |
| 44 | Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells | Phytomedicine | 2010 | 83 |
| 45 | Lignans from Phyllanthus urinaria | Phytochemistry | 2003 | 81 |
| 46 | Hyaluronic acid conjugated micelles possessing CD44 targeting potential for gene delivery | Carbohydrate Polymers | 2017 | 81 |
| 47 | Superoxide Anion Scavenging Effect of Coumarins | The American Journal of Chinese Medicine | 1996 | 80 |
| 48 | CLEC4F Is an Inducible C-Type Lectin in F4/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver | PLoS ONE | 2013 | 79 |
| 49 | Xanthine Oxidase Inhibitors from the Leaves ofAlsophila Spinulosa(HOOK) Tryon | Journal of Enzyme Inhibition and Medicinal Chemistry | 1994 | 77 |
| 50 | The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats | Psychopharmacology | 2005 | 76 |
