| # | Title | Journal | Year | Citations |
|---|
| 1 | Primary bioassay of human tumor stem cells | Science | 1977 | 1,738 |
| 2 | Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients | Food and Chemical Toxicology | 2015 | 1,418 |
| 3 | Outcomes of Rapid Defibrillation by Security Officers after Cardiac Arrest in Casinos | New England Journal of Medicine | 2000 | 1,336 |
| 4 | The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed | Journal of Bone and Mineral Research | 1998 | 1,217 |
| 5 | Ancient human genomes suggest three ancestral populations for present-day Europeans | Nature | 2014 | 1,179 |
| 6 | Licensing of natural killer cells by host major histocompatibility complex class I molecules | Nature | 2005 | 1,144 |
| 7 | Vitamin D Receptor As an Intestinal Bile Acid Sensor | Science | 2002 | 1,053 |
| 8 | Neurobiology of muscle fatigue | Journal of Applied Physiology | 1992 | 1,021 |
| 9 | A Clinical Index to Define Risk of Asthma in Young Children with Recurrent Wheezing | American Journal of Respiratory and Critical Care Medicine | 2000 | 996 |
| 10 | Sex and gender: modifiers of health, disease, and medicine | Lancet, The | 2020 | 955 |
| 11 | The role of gut microbiota in immune homeostasis and autoimmunity | Gut Microbes | 2012 | 881 |
| 12 | The Arizona Sexual Experience Scale (ASEX): Reliability and Validity | Journal of Sex and Marital Therapy | 2000 | 842 |
| 13 | Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells | Science | 1988 | 828 |
| 14 | Loneliness: A signature mental health concern in the era of COVID-19 | Psychiatry Research | 2020 | 652 |
| 15 | THE FRAMINGHAM EYE STUDY | American Journal of Epidemiology | 1977 | 635 |
| 16 | CYTOKINE TARGETS IN THE BRAIN: IMPACT ON NEUROTRANSMITTERS AND NEUROCIRCUITS | Depression and Anxiety | 2013 | 589 |
| 17 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome | Gastroenterology | 2008 | 588 |
| 18 | Diagnosis and management of acute kidney injury in patients with cirrhosis: Revised consensus recommendations of the International Club of Ascites | Journal of Hepatology | 2015 | 571 |
| 19 | Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial | BJU International | 1998 | 564 |
| 20 | Basic and Clinical Concepts Related to Vitamin D Metabolism and Action | New England Journal of Medicine | 1977 | 550 |
| 21 | Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury | Gastroenterology | 2003 | 541 |
| 22 | Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group | JAMA - Journal of the American Medical Association | 1996 | 541 |
| 23 | Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. | Journal of Clinical Oncology | 1989 | 531 |
| 24 | Taurine in the central nervous system and the mammalian actions of taurine | Progress in Neurobiology | 1989 | 525 |
| 25 | Rhinitis as an independent risk factor for adult-onset asthma | Journal of Allergy and Clinical Immunology | 2002 | 508 |
| 26 | Bile acids as carcinogens in human gastrointestinal cancers | Mutation Research - Reviews in Mutation Research | 2005 | 505 |
| 27 | Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death | Toxicological Sciences | 2006 | 490 |
| 28 | Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial | BJU International | 2003 | 460 |
| 29 | Increased Incidence of Asthmalike Symptoms in Girls Who Become Overweight or Obese during the School Years | American Journal of Respiratory and Critical Care Medicine | 2001 | 453 |
| 30 | DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis | Mutation Research - Reviews in Mutation Research | 2002 | 443 |
| 31 | Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing | Nature Reviews Drug Discovery | 2020 | 441 |
| 32 | The Course and Prognosis of Different Forms of Chronic Airways Obstruction in a Sample from the General Population | New England Journal of Medicine | 1987 | 436 |
| 33 | Invited Review: Effects of acute exercise and exercise training on insulin resistance | Journal of Applied Physiology | 2002 | 427 |
| 34 | Biological effects of residual glutaraldehyde in glutaraldehyde-tanned collagen biomaterials | Journal of Biomedical Materials Research Part B | 1980 | 408 |
| 35 | Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites | Gut | 2015 | 405 |
| 36 | THE FRAMINGHAM EYE STUDY | American Journal of Epidemiology | 1977 | 400 |
| 37 | Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions | American Journal of Physiology - Renal Physiology | 2006 | 398 |
| 38 | Topical vitamin e inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation | Nutrition and Cancer | 1991 | 393 |
| 39 | Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation | Journal of Translational Medicine | 2014 | 391 |
| 40 | The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity | Toxicology Letters | 2003 | 386 |
| 41 | Regulation of serum 1alpha,25-dihydroxyvitamin D3 by calcium and phosphate in the rat | Science | 1975 | 385 |
| 42 | Molecular and Cellular Physiology of Renal Organic Cation and Anion Transport | Physiological Reviews | 2004 | 377 |
| 43 | Muscimol binding in rat brain: Association with synaptic GABA receptors | Brain Research | 1978 | 369 |
| 44 | Frequency and Costs of Diagnostic Imaging in Office Practice — A Comparison of Self-Referring and Radiologist-Referring Physicians | New England Journal of Medicine | 1990 | 365 |
| 45 | New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes | Life Sciences | 1973 | 359 |
| 46 | 1α,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport | American Journal of Physiology - Renal Physiology | 2005 | 359 |
| 47 | Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene | Molecular and Cellular Endocrinology | 2001 | 354 |
| 48 | Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection | American Journal of Physiology - Cell Physiology | 2018 | 351 |
| 49 | Frailty: An Emerging Geriatric Syndrome | American Journal of Medicine | 2007 | 343 |
| 50 | The Polymorphic N Terminus in Human Vitamin D Receptor Isoforms Influences Transcriptional Activity by Modulating Interaction with Transcription Factor IIB | Molecular Endocrinology | 2000 | 339 |
