| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | A cytokine-mediated link between innate immunity, inflammation, and cancer | Journal of Clinical Investigation | 2007 | 1,629 |
| 4 | Stability of curcumin in buffer solutions and characterization of its degradation products | Journal of Pharmaceutical and Biomedical Analysis | 1997 | 1,401 |
| 5 | Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis | American Journal of Pathology | 2010 | 1,281 |
| 6 | Guidelines and definitions for research on epithelial–mesenchymal transition | Nature Reviews Molecular Cell Biology | 2020 | 1,195 |
| 7 | Direct regulation of TWIST by HIF-1α promotes metastasis | Nature Cell Biology | 2008 | 1,187 |
| 8 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial | Lancet, The | 2007 | 1,153 |
| 9 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma | Hepatology International | 2010 | 944 |
| 10 | VPS35 Mutations in Parkinson Disease | American Journal of Human Genetics | 2011 | 747 |
| 11 | Biotransformation of curcumin through reduction and glucuronidation in mice | Drug Metabolism and Disposition | 1999 | 627 |
| 12 | Loneliness and social isolation during the COVID-19 pandemic | International Psychogeriatrics | 2020 | 625 |
| 13 | (−)-Epigallocatechin-3-gallate Blocks the Induction of Nitric Oxide Synthase by Down-Regulating Lipopolysaccharide-Induced Activity of Transcription Factor Nuclear Factor-κB | Molecular Pharmacology | 1997 | 524 |
| 14 | Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages | Carcinogenesis | 1999 | 520 |
| 15 | Metabolic Factors and Risk of Hepatocellular Carcinoma by Chronic Hepatitis B/C Infection: A Follow-up Study in Taiwan | Gastroenterology | 2008 | 492 |
| 16 | Computer-Aided Diagnosis with Deep Learning Architecture: Applications to Breast Lesions in US Images and Pulmonary Nodules in CT Scans | Scientific Reports | 2016 | 488 |
| 17 | Effect of Exercise on Physical Function, Daily Living Activities, and Quality of Life in the Frail Older Adults: A Meta-Analysis | Archives of Physical Medicine and Rehabilitation | 2012 | 480 |
| 18 | Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes | Cardiovascular Research | 2000 | 463 |
| 19 | Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway | Oncogene | 2003 | 463 |
| 20 | Suppression of nitric oxide synthase and the down-regulation of the activation of NFκB in macrophages by resveratrol | British Journal of Pharmacology | 1999 | 450 |
| 21 | Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells | Journal of Immunology | 2009 | 443 |
| 22 | Prevalence of psychiatric disorders in Taiwan defined by the Chinese Diagnostic Interview Schedule | Acta Psychiatrica Scandinavica | 1989 | 442 |
| 23 | In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation | Journal of Biomaterials Science, Polymer Edition | 1999 | 423 |
| 24 | Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis | Journal of Cellular Physiology | 1998 | 420 |
| 25 | Exercise training improves sleep quality in middle-aged and older adults with sleep problems: a systematic review | Journal of Physiotherapy | 2012 | 418 |
| 26 | Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells | European Journal of Cancer | 1999 | 416 |
| 27 | p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug | Nature Cell Biology | 2009 | 414 |
| 28 | Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide | Science | 2011 | 414 |
| 29 | Epidemiologic Study of Ocular Refraction among Schoolchildren in Taiwan in 1995 | Optometry and Vision Science | 1999 | 404 |
| 30 | YC-1, a novel activator of platelet guanylate cyclase | Blood | 1994 | 393 |
| 31 | Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial | Lancet Oncology, The | 2012 | 390 |
| 32 | Analysis and Comparison of the Psychometric Properties of Three Balance Measures for Stroke Patients | Stroke | 2002 | 375 |
| 33 | TGF-β induces apoptosis through Smad-mediated expression of DAP-kinase | Nature Cell Biology | 2002 | 359 |
| 34 | Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 357 |
| 35 | Prevalence of Sarcopenia Estimated Using a Bioelectrical Impedance Analysis Prediction Equation in Community‐Dwelling Elderly People in Taiwan | Journal of the American Geriatrics Society | 2008 | 354 |
| 36 | Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives | Oral Oncology | 2001 | 349 |
| 37 | Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 347 |
| 38 | An updated Asia Pacific Consensus Recommendations on colorectal cancer screening | Gut | 2015 | 345 |
| 39 | The large form of hepatitis delta antigen is crucial for assembly of hepatitis delta virus. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 343 |
| 40 | Thermal decomposition and reconstitution of hydroxyapatite in air atmosphere | Biomaterials | 1999 | 342 |
| 41 | Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 1996 | 340 |
| 42 | Factors Affecting the Levels of Tea Polyphenols and Caffeine in Tea Leaves | Journal of Agricultural and Food Chemistry | 2003 | 339 |
| 43 | Neurodevelopment and Cognition in Children after Enterovirus 71 Infection | New England Journal of Medicine | 2007 | 336 |
| 44 | Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages | Biochemical Pharmacology | 2000 | 335 |
| 45 | Sex Differences in High‐fat Diet‐induced Obesity, Metabolic Alterations and Learning, and Synaptic Plasticity Deficits in Mice | Obesity | 2010 | 330 |
| 46 | Drug candidates in clinical trials for Alzheimer’s disease | Journal of Biomedical Science | 2017 | 330 |
| 47 | Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade | Biochemical Pharmacology | 1999 | 328 |
| 48 | Test-Retest Reproducibility and Smallest Real Difference of 5 Hand Function Tests in Patients With Stroke | Neurorehabilitation and Neural Repair | 2009 | 327 |
| 49 | Comparison of the psychometric characteristics of the functional independence measure, 5 item Barthel index, and 10 item Barthel index in patients with stroke | Journal of Neurology, Neurosurgery and Psychiatry | 2002 | 325 |
| 50 | Effect of Pentoxifylline in Addition to Losartan on Proteinuria and GFR in CKD: A 12-Month Randomized Trial | American Journal of Kidney Diseases | 2008 | 325 |
