| # | Title | Journal | Year | Citations |
|---|
| 1 | Chalcone: A Privileged Structure in Medicinal Chemistry | Chemical Reviews | 2017 | 938 |
| 2 | Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp. | Journal of the American Chemical Society | 2008 | 394 |
| 3 | A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity | Nature Medicine | 2019 | 348 |
| 4 | Marine natural products: a new wave of drugs? | Future Medicinal Chemistry | 2011 | 340 |
| 5 | Agouti-related protein functions as an inverse agonist at a constitutively active brain melanocortin-4 receptor | Regulatory Peptides | 2001 | 224 |
| 6 | Patterns of Kratom use and health impact in the US—Results from an online survey | Drug and Alcohol Dependence | 2017 | 208 |
| 7 | Mammalian phytoestrogens: enterodiol and enterolactone | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | 2002 | 196 |
| 8 | Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression | Nature Cell Biology | 2010 | 190 |
| 9 | Site-specific, sustained release of drugs to the brain | Science | 1981 | 183 |
| 10 | Synthetic polyamine analogs as antineoplastics | Journal of Medicinal Chemistry | 1988 | 175 |
| 11 | A genomic screen for activators of the antioxidant response element | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 168 |
| 12 | Irritable bowel syndrome: Epidemiology, diagnosis and treatment: An update for health‐care practitioners | Journal of Gastroenterology and Hepatology (Australia) | 2010 | 167 |
| 13 | TRICLOSAN AS A SUBSTRATE AND INHIBITOR OF 3′-PHOSPHOADENOSINE 5′-PHOSPHOSULFATE-SULFOTRANSFERASE AND UDP-GLUCURONOSYL TRANSFERASE IN HUMAN LIVER FRACTIONS | Drug Metabolism and Disposition | 2004 | 160 |
| 14 | Quinol-based cyclic antioxidant mechanism in estrogen neuroprotection | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 155 |
| 15 | Largazole: From discovery to broad-spectrum therapy | Natural Product Reports | 2012 | 154 |
| 16 | Head‐twitch response in rodents induced by the hallucinogen 2,5‐dimethoxy‐4‐iodoamphetamine: a comprehensive history, a re‐evaluation of mechanisms, and its utility as a model | Drug Testing and Analysis | 2012 | 154 |
| 17 | The pharmacology and toxicology of kratom: from traditional herb to drug of abuse | International Journal of Legal Medicine | 2016 | 150 |
| 18 | Problems of delivery of drugs to the brain | | 1982 | 146 |
| 19 | Structure Activity Studies of the Melanocortin-4 Receptor by in Vitro Mutagenesis: Identification of Agouti-Related Protein (AGRP), Melanocortin Agonist and Synthetic Peptide Antagonist Interaction Determinants | Biochemistry | 2001 | 146 |
| 20 | Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity | Nature Communications | 2020 | 141 |
| 21 | PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics | Oncogene | 2020 | 139 |
| 22 | The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse | Neuropharmacology | 2018 | 138 |
| 23 | Antineoplastic and antiherpetic activity of spermidine catecholamide iron chelators | Biochemical and Biophysical Research Communications | 1984 | 137 |
| 24 | Pharmacological Characterization of 40 Human Melanocortin-4 Receptor Polymorphisms with the Endogenous Proopiomelanocortin-Derived Agonists and the Agouti-Related Protein (AGRP) Antagonist, | Biochemistry | 2006 | 135 |
| 25 | Biological targets and mechanisms of action of natural products from marine cyanobacteria | Natural Product Reports | 2015 | 133 |
| 26 | Irisin exerts dual effects on browning and adipogenesis of human white adipocytes | American Journal of Physiology - Endocrinology and Metabolism | 2016 | 133 |
| 27 | Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation | Molecular Pharmacology | 2009 | 129 |
| 28 | Inhibition of Sulfotransferases by Xenobiotics | Current Drug Metabolism | 2006 | 128 |
| 29 | The Proopiomelanocortin System | Annals of the New York Academy of Sciences | 1999 | 126 |
| 30 | A Comparison of Structure−Activity Relationships between Spermidine and Spermine Analogue Antineoplastics | Journal of Medicinal Chemistry | 1997 | 125 |
| 31 | The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review | European Journal of Clinical Nutrition | 2015 | 124 |
| 32 | Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies | Medicinal Research Reviews | 2004 | 122 |
| 33 | Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine Cyanobacterium Lyngbya bouillonii | Journal of Natural Products | 2008 | 121 |
| 34 | Lyngbyastatins 5–7, Potent Elastase Inhibitors from Floridian Marine Cyanobacteria, Lyngbya spp. | Journal of Natural Products | 2007 | 119 |
| 35 | Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta | Environment International | 2010 | 111 |
| 36 | Cytochrome P450 monooxygenases in crustaceans | Xenobiotica | 1989 | 110 |
| 37 | Antiproliferative Properties of Polyamine Analogs: A Structure-Activity Study | Journal of Medicinal Chemistry | 1994 | 109 |
| 38 | Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor | Journal of Pharmacology and Experimental Therapeutics | 2010 | 106 |
| 39 | Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine | Addiction Biology | 2019 | 103 |
| 40 | Evaluation of desferrithiocin and its synthetic analogs as orally effective iron chelators | Journal of Medicinal Chemistry | 1991 | 100 |
| 41 | The curcumin analog EF24 is a novel senolytic agent | Aging | 2019 | 100 |
| 42 | Cytotoxic Halogenated Macrolides and Modified Peptides from the Apratoxin-Producing Marine Cyanobacterium Lyngbya bouillonii from Guam | Journal of Natural Products | 2010 | 99 |
| 43 | Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1 | | 2017 | 98 |
| 44 | Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway | Free Radical Biology and Medicine | 2013 | 97 |
| 45 | Redox delivery system for brain-specific, sustained release of dopamine | Science | 1983 | 96 |
| 46 | Chemistry and Biology of Synthetic and Naturally Occurring Antiamoebic Agents | Chemical Reviews | 2009 | 95 |
| 47 | Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency | Nature Biomedical Engineering | 2017 | 95 |
| 48 | Oxidation resistance 1 is a novel senolytic target | Aging Cell | 2018 | 95 |
| 49 | Protein Microarrays to Detect Protein–Protein Interactions Using Red and Green Fluorescent Proteins | Analytical Biochemistry | 2002 | 94 |
| 50 | Lyngbyastatin 4, a Dolastatin 13 Analogue with Elastase and Chymotrypsin Inhibitory Activity from the Marine Cyanobacterium Lyngbya confervoides | Journal of Natural Products | 2007 | 94 |
