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Top Articles

#TitleJournalYearCitations
1DNA methylation and human diseaseNature Reviews Genetics20052,449
2The family ParvoviridaeArchives of Virology2014555
3Arrangement of rhodopsin transmembrane α-helicesNature1997486
4ATF4-dependent transcription mediates signaling of amino acid limitationTrends in Endocrinology and Metabolism2009469
5The regulation of neutral amino acid transport in mammalian cellsBBA - Biomembranes1983433
6MicroRNA-125b Confers the Resistance of Breast Cancer Cells to Paclitaxel through Suppression of Pro-apoptotic Bcl-2 Antagonist Killer 1 (Bak1) ExpressionJournal of Biological Chemistry2010370
7Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant CellsTrends in Endocrinology and Metabolism2017356
8Resolution of complex tissue microarchitecture using the diffusion orientation transform (DOT)NeuroImage2006346
9Palaeotemperature trend for Precambrian life inferred from resurrected proteinsNature2008338
10A blend of small molecules regulates both mating and development in Caenorhabditis elegansNature2008335
11DNA Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Reversible Genome-Wide DNA Damage That Is Distinctly Influenced by DNA Methyltransferases 1 and 3BMolecular and Cellular Biology2008321
12Hyperpolarized 13C MRI: Path to Clinical Translation in OncologyNeoplasia2019316
13Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to TaxolMolecular Cancer2010307
14Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's diseaseEMBO Molecular Medicine2013270
15α2,3 and α2,6 N-Linked Sialic Acids Facilitate Efficient Binding and Transduction by Adeno-Associated Virus Types 1 and 6Journal of Virology2006268
16Manganese Superoxide Dismutase Attenuates Cisplatin-Induced Renal InjuryJournal of the American Society of Nephrology: JASN2001243
175′ cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesisEMBO Journal2001242
18Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)PLoS Genetics2009234
19Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loopNature1983231
20Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological NanoparticlesMolecular Therapy2008224
21The story so far: molecular regulation of the heme oxygenase-1 gene in renal injuryAmerican Journal of Physiology - Renal Physiology2004216
22DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune functionHuman Molecular Genetics2008216
23Amino acid transport in isolated rat hepatocytesJournal of Membrane Biology1982215
24Dithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in VivoJournal of Medicinal Chemistry2012211
25A Modular Library of Small Molecule Signals Regulates Social Behaviors in Caenorhabditis elegansPLoS Biology2012208
26A novel tensor distribution model for the diffusion-weighted MR signalNeuroImage2007204
27A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor GrowthJournal of Medicinal Chemistry2008204
28Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potencyChemical Communications2010200
29Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiolMolecular and Cellular Endocrinology2004199
30Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy VectorJournal of Virology2007199
31Molecular Biology of Mammalian Amino Acid TransportersAnnual Review of Biochemistry1996197
32Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase IIJournal of Biological Chemistry2008197
33Asparagine synthetase: Function, structure, and role in diseaseJournal of Biological Chemistry2017197
34Single Amino Acid Changes Can Influence Titer, Heparin Binding, and Tissue Tropism in Different Adeno-Associated Virus SerotypesJournal of Virology2006194
35Endothelin‐1 gene regulationFASEB Journal2011189
36Structural annotation of human carbonic anhydrasesJournal of Enzyme Inhibition and Medicinal Chemistry2013189
37Recent Advances in Mammalian Amino Acid TransportAnnual Review of Nutrition1993188
38A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selectionProceedings of the National Academy of Sciences of the United States of America2009187
39Structure of the Maize Streak Virus Geminate ParticleVirology2001180
40Carbonic Anhydrases: Role in pH Control and CancerMetabolites2018180
41Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene TransferMolecular Therapy2011179
42A metastable liquid precursor phase of calcium carbonate and its interactions with polyaspartateFaraday Discussions2012173
43A comparison of the estrogenic potencies of estradiol, ethynylestradiol, diethylstilbestrol, nonylphenol and methoxychlor in vivo and in vitroAquatic Toxicology2002172
44Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent reviewExpert Opinion on Therapeutic Patents2013172
45Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in miceNature1999170
46CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasisMolecular Biology of the Cell2013170
47Structurally Mapping the Diverse Phenotype of Adeno-Associated Virus Serotype 4Journal of Virology2006165
48Adeno-Associated Virus Type 2 Contains an Integrin α5β1 Binding Domain Essential for Viral Cell EntryJournal of Virology2006164
49Structural Insight into the Unique Properties of Adeno-Associated Virus Serotype 9Journal of Virology2012163
50Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassayAquatic Toxicology2000162