Department of Ophthalmology

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#	Title	Journal	Year	Citations
1	Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial	Human Gene Therapy	2008	880
2	Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics	Proceedings of the National Academy of Sciences of the United States of America	2008	639
3	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration	Nature	2011	573
4	DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88	Cell	2012	526
5	Arrangement of rhodopsin transmembrane α-helices	Nature	1997	486
6	Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement	Proceedings of the National Academy of Sciences of the United States of America	2013	401
7	High-efficiency Transduction of the Mouse Retina by Tyrosine-mutant AAV Serotype Vectors	Molecular Therapy	2009	355
8	Long-term Morphologic Effects of Antiglaucoma Drugs on the Conjunctiva and Tenon's Capsule in Glaucomatous Patients	Ophthalmology	1989	337
9	Improvement and Decline in Vision with Gene Therapy in Childhood Blindness	New England Journal of Medicine	2015	333
10	Rhodopsin and phototransduction: a model system for G protein‐linked receptors	FASEB Journal	1992	310
11	HumanRPE65Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year	Human Gene Therapy	2009	305
12	Normative Data for Macular Thickness by High-Definition Spectral-Domain Optical Coherence Tomography (Spectralis)	American Journal of Ophthalmology	2009	274
13	Lifetime prevalence of uveal melanoma in white patients with oculo(dermal) melanocytosis	Ophthalmology	1998	247
14	A Comprehensive Review of Retinal Gene Therapy	Molecular Therapy	2013	245
15	Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice	Diabetes	2018	243
16	Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death	Proceedings of the National Academy of Sciences of the United States of America	2013	239
17	Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa	Proceedings of the National Academy of Sciences of the United States of America	2012	237
18	Novel Properties of Tyrosine-mutant AAV2 Vectors in the Mouse Retina	Molecular Therapy	2011	234
19	Anti-rhodopsin monoclonal antibodies of defined specificity: Characterization and application	Vision Research	1991	225
20	Safety of Recombinant Adeno-Associated Virus Type 2–RPE65 Vector Delivered by Ocular Subretinal Injection	Molecular Therapy	2006	196
21	Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial	Human Genetics	2016	195
22	Late endophthalmitis associated with glaucoma drainage implants	Ophthalmology	2001	189
23	Rhodopsin structure, function, and topography the Friedenwald lecture	Investigative Ophthalmology and Visual Science	2001	189
24	Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor	Diabetologia	1993	185
25	Phosphorylation sites in bovine rhodopsin	Biochemistry	1993	185
26	Gene Therapy Restores Vision-Dependent Behavior as Well as Retinal Structure and Function in a Mouse Model of RPE65 Leber Congenital Amaurosis	Molecular Therapy	2006	185
27	Pharmacological Chaperone-mediated in Vivo Folding and Stabilization of the P23H-opsin Mutant Associated with Autosomal Dominant Retinitis Pigmentosa	Journal of Biological Chemistry	2003	183
28	Interaction of rhodopsin with the G-protein, transducin	BioEssays	1993	181
29	Endothelial Damage Associated with Intraocular Lenses	American Journal of Ophthalmology	1976	173
30	Glaucoma’s impact on quality of life and its relation to clinical indicators	Ophthalmology	1998	168
31	Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps	Translational Vision Science and Technology	2018	168
32	Prolonged Recovery of Retinal Structure/Function after Gene Therapy in an Rs1h-Deficient Mouse Model of X-Linked Juvenile Retinoschisis	Molecular Therapy	2005	166
33	Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model	Proceedings of the National Academy of Sciences of the United States of America	2019	162
34	Clinical and Microbiological Characteristics of Fungal Keratitis in the United States, 2001–2007: A Multicenter Study	Ophthalmology	2011	161
35	Cytotoxicity of Ophthalmic Preservatives	American Journal of Ophthalmology	1974	160
36	Endothelial dysfunction as a potential contributor in diabetic nephropathy	Nature Reviews Nephrology	2011	159
37	Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA)	Molecular Vision	2005	159
38	Central Cornea Guttata	American Journal of Ophthalmology	1967	153
39	Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors	Redox Biology	2019	146
40	Treatment of Paraneoplastic Visual Loss With Intravenous Immunoglobulin	JAMA Ophthalmology	1999	144
41	Retinoids Assist the Cellular Folding of the Autosomal Dominant Retinitis Pigmentosa Opsin Mutant P23H	Journal of Biological Chemistry	2004	144
42	ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy	Molecular Therapy	2012	143
43	Safety in Nonhuman Primates of Ocular AAV2-RPE65, a Candidate Treatment for Blindness in Leber Congenital Amaurosis	Human Gene Therapy	2006	142
44	Effects of Intraoperative 5-Fluorouracil or Mitomycin C on Glaucoma Filtration Surgery in the Rabbit	Ophthalmology	1993	141
45	Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa	American Journal of Ophthalmology	1999	140
46	Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential	Molecular Vision	2008	140
47	Ophthalmic Manifestations of Rochalimaea Species	American Journal of Ophthalmology	1994	139
48	Stereoscopic Perception and Snellen Visual Acuity	American Journal of Ophthalmology	1974	135
49	Long-term Retinal Function and Structure Rescue Using Capsid Mutant AAV8 Vector in the rd10 Mouse, a Model of Recessive Retinitis Pigmentosa	Molecular Therapy	2011	135
50	Rhodopsin kinase: substrate specificity and factors that influence activity	Biochemistry	1988	129

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