| # | Title | Journal | Year | Citations |
|---|
| 1 | Cellular Senescence: Defining a Path Forward | Cell | 2019 | 1,551 |
| 2 | Opportunities and responsibilities in pharmaceutical care | American Journal of Hospital Pharmacy | 1990 | 1,322 |
| 3 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 4 | Opportunities and responsibilities in pharmaceutical care | American Journal of Health-System Pharmacy | 1990 | 939 |
| 5 | Chalcone: A Privileged Structure in Medicinal Chemistry | Chemical Reviews | 2017 | 938 |
| 6 | Validity and reliability of measurement instruments used in research | American Journal of Health-System Pharmacy | 2008 | 827 |
| 7 | Center for the Advancement of Pharmacy Education 2013 Educational Outcomes | American Journal of Pharmaceutical Education | 2013 | 790 |
| 8 | Tight Blood Pressure Control and Cardiovascular Outcomes Among Hypertensive Patients With Diabetes and Coronary Artery Disease | JAMA - Journal of the American Medical Association | 2010 | 578 |
| 9 | Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans | Journal of Clinical Pharmacology | 2001 | 510 |
| 10 | Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat | Journal of Neurosurgery | 1997 | 481 |
| 11 | Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats | Brain Research | 1994 | 456 |
| 12 | The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats. | Endocrinology | 1995 | 389 |
| 13 | Pharmacokinetic/Pharmacodynamic Profile of Voriconazole | Clinical Pharmacokinetics | 2006 | 386 |
| 14 | What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study) | Journal of Nutrition, Health and Aging | 2009 | 378 |
| 15 | The cost of health care for children and adults with sickle cell disease | American Journal of Hematology | 2009 | 368 |
| 16 | How Important Are Gender Differences in Pharmacokinetics? | Clinical Pharmacokinetics | 2002 | 365 |
| 17 | Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells | Journal of Extracellular Vesicles | 2017 | 357 |
| 18 | Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges | Nature Reviews Drug Discovery | 2007 | 351 |
| 19 | A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity | Nature Medicine | 2019 | 348 |
| 20 | Systematic Review of the Incidence and Characteristics of Preventable Adverse Drug Events in Ambulatory Care | Annals of Pharmacotherapy | 2007 | 325 |
| 21 | Nocturia: A Risk Factor for Falls in the Elderly | Journal of the American Geriatrics Society | 1992 | 286 |
| 22 | Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives | | 1999 | 275 |
| 23 | β1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol | Clinical Pharmacology and Therapeutics | 2003 | 269 |
| 24 | Pharmacokinetic aspects of biotechnology products | Journal of Pharmaceutical Sciences | 2004 | 268 |
| 25 | Significance of Protein Binding in Pharmacokinetics and Pharmacodynamics | Journal of Pharmaceutical Sciences | 2010 | 267 |
| 26 | Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models | CPT: Pharmacometrics and Systems Pharmacology | 2015 | 264 |
| 27 | Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Kill Curves versus MIC | Antimicrobial Agents and Chemotherapy | 2004 | 262 |
| 28 | Disability Measures in Stroke | Stroke | 2004 | 259 |
| 29 | Preventable Drug-Related Hospital Admissions | Annals of Pharmacotherapy | 2002 | 250 |
| 30 | Issues in Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents: Distribution in Tissue | Antimicrobial Agents and Chemotherapy | 2004 | 237 |
| 31 | Nature of preventable adverse drug events in hospitals: a literature review | American Journal of Health-System Pharmacy | 2003 | 227 |
| 32 | Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats | Experimental Physiology | 2005 | 214 |
| 33 | Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma | European Respiratory Journal | 2006 | 212 |
| 34 | Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring | Molecular Pharmacology | 2019 | 211 |
| 35 | Pharmacokinetic/Pharmacodynamic Profile of Posaconazole | Clinical Pharmacokinetics | 2010 | 210 |
| 36 | Patterns of Kratom use and health impact in the US—Results from an online survey | Drug and Alcohol Dependence | 2017 | 208 |
| 37 | A review of medication errors and compliance in ambulant patients | Clinical Pharmacology and Therapeutics | 1972 | 205 |
| 38 | Liver disease selectively modulates cytochrome P450–mediated metabolism | Clinical Pharmacology and Therapeutics | 2006 | 203 |
| 39 | The lipopolysaccharide Parkinson’s disease animal model: mechanistic studies and drug discovery | Fundamental and Clinical Pharmacology | 2008 | 197 |
| 40 | Mammalian phytoestrogens: enterodiol and enterolactone | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences | 2002 | 196 |
| 41 | Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans | Phytomedicine | 2005 | 195 |
| 42 | Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol | Journal of Pharmaceutical Sciences | 1974 | 192 |
| 43 | Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement | Blood | 2008 | 187 |
| 44 | Clinical pharmacology of the dietary supplement creatine monohydrate | Pharmacological Reviews | 2001 | 187 |
| 45 | Site-specific, sustained release of drugs to the brain | Science | 1981 | 183 |
| 46 | Basic concepts of pharmacokinetic/pharmacodynamic (PK/PD) modelling | International Journal of Clinical Pharmacology and Therapeutics | 1997 | 183 |
| 47 | Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension | American Journal of Physiology - Heart and Circulatory Physiology | 2006 | 182 |
| 48 | Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase | FASEB Journal | 2004 | 181 |
| 49 | Sterilizing Activity of Novel TMC207- and PA-824-Containing Regimens in a Murine Model of Tuberculosis | Antimicrobial Agents and Chemotherapy | 2011 | 181 |
| 50 | Phenolic A ring requirement for the neuroprotective effects of steroids | Journal of Steroid Biochemistry and Molecular Biology | 1997 | 179 |
