| # | Title | Journal | Year | Citations |
|---|
| 1 | Drug repurposing: progress, challenges and recommendations | Nature Reviews Drug Discovery | 2019 | 2,689 |
| 2 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
| 3 | ESCMID guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients | Clinical Microbiology and Infection | 2012 | 977 |
| 4 | Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions | Lancet Infectious Diseases, The | 2014 | 745 |
| 5 | Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial | Lancet, The | 2016 | 695 |
| 6 | Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations | Nucleic Acids Research | 2015 | 693 |
| 7 | Novel role of PKR in inflammasome activation and HMGB1 release | Nature | 2012 | 672 |
| 8 | Emergence and global spread of epidemic healthcare-associated Clostridium difficile | Nature Genetics | 2013 | 669 |
| 9 | A living WHO guideline on drugs for covid-19 | BMJ, The | 2020 | 664 |
| 10 | Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release | Journal of Experimental Medicine | 2012 | 590 |
| 11 | Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology | Journal of Antimicrobial Chemotherapy | 2014 | 525 |
| 12 | Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial | Lancet, The | 2021 | 519 |
| 13 | Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease | Scientific Reports | 2016 | 502 |
| 14 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics‐Guided Warfarin Dosing: 2017 Update | Clinical Pharmacology and Therapeutics | 2017 | 479 |
| 15 | The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis | Journal of Leukocyte Biology | 2013 | 449 |
| 16 | ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others | Clinical Microbiology and Infection | 2014 | 383 |
| 17 | Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study | Brain | 2018 | 352 |
| 18 | Allele frequency net database (AFND) 2020 update: gold-standard data classification, open access genotype data and new query tools | Nucleic Acids Research | 2020 | 352 |
| 19 | Liposomal Amphotericin B (AmBisome®): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions | Drugs | 2016 | 332 |
| 20 | Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis | Nature Cell Biology | 2016 | 329 |
| 21 | Fourth European Conference on Infections in Leukaemia (ECIL-4): guidelines for diagnosis, prevention, and treatment of invasive fungal diseases in paediatric patients with cancer or allogeneic haemopoietic stem-cell transplantation | Lancet Oncology, The | 2014 | 325 |
| 22 | Tissue Penetration of Antifungal Agents | Clinical Microbiology Reviews | 2014 | 319 |
| 23 | ESCMID guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures | Clinical Microbiology and Infection | 2012 | 310 |
| 24 | How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? | British Journal of Pharmacology | 2011 | 306 |
| 25 | JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 300 |
| 26 | MD-2 is required for disulfide HMGB1–dependent TLR4 signaling | Journal of Experimental Medicine | 2015 | 295 |
| 27 | Predictors of health-related quality of life and costs in adults with epilepsy: A systematic review | Epilepsia | 2011 | 283 |
| 28 | ESCMID guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT) | Clinical Microbiology and Infection | 2012 | 280 |
| 29 | The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs | Journal of Neurology, Neurosurgery and Psychiatry | 2013 | 280 |
| 30 | ESCMID guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. | Clinical Microbiology and Infection | 2012 | 264 |
| 31 | ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi | Clinical Microbiology and Infection | 2014 | 262 |
| 32 | Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice | Blood | 2016 | 219 |
| 33 | Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study | Toxicological Sciences | 2018 | 219 |
| 34 | Management of allergy to penicillins and other beta‐lactams | Clinical and Experimental Allergy | 2015 | 210 |
| 35 | Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy | Molecular Cancer | 2011 | 200 |
| 36 | ERK5: Structure, regulation and function | Cellular Signalling | 2012 | 199 |
| 37 | Prevalence of neurologic autoantibodies in cohorts of patients with new and established epilepsy | Epilepsia | 2013 | 199 |
| 38 | Combining antiepileptic drugs—Rational polytherapy? | Seizure: the Journal of the British Epilepsy Association | 2011 | 195 |
| 39 | Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists | PLoS ONE | 2012 | 191 |
| 40 | F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 187 |
| 41 | Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis | Lancet Neurology, The | 2017 | 184 |
| 42 | Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study | Gastroenterology | 2017 | 174 |
| 43 | Phenotype Standardization for Statin-Induced Myotoxicity | Clinical Pharmacology and Therapeutics | 2014 | 166 |
| 44 | Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2 | Free Radical Biology and Medicine | 2015 | 161 |
| 45 | Role of Nrf2 in protection against acute kidney injury | Kidney International | 2013 | 158 |
| 46 | Development and Inter-Rater Reliability of the Liverpool Adverse Drug Reaction Causality Assessment Tool | PLoS ONE | 2011 | 157 |
| 47 | Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles | Nature Communications | 2014 | 153 |
| 48 | Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis | Toxicology and Applied Pharmacology | 2015 | 153 |
| 49 | Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models | Nature Reviews Drug Discovery | 2020 | 153 |
| 50 | Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives | Nature Communications | 2021 | 149 |
