| # | Title | Journal | Year | Citations |
|---|
| 1 | Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis | Cancer Cell | 2006 | 1,779 |
| 2 | Autophagy Suppresses Tumorigenesis through Elimination of p62 | Cell | 2009 | 1,544 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | Life, death, and the pursuit of apoptosis. | Genes and Development | 1996 | 1,198 |
| 5 | Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 1,179 |
| 6 | Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis | Genes and Development | 2011 | 1,093 |
| 7 | Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. | Genes and Development | 1993 | 833 |
| 8 | The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 728 |
| 9 | The Hepatitis B Virus Polymerase Mutation rtV173L Is Selected during Lamivudine Therapy and Enhances Viral Replication In Vitro | Journal of Virology | 2003 | 531 |
| 10 | Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae | Genetics | 2001 | 377 |
| 11 | Bcl-2 blocks p53-dependent apoptosis. | Molecular and Cellular Biology | 1994 | 374 |
| 12 | How a Circadian Clock Adapts to Seasonal Decreases in Temperature and Day Length | Neuron | 1999 | 371 |
| 13 | Structural basis of RNA recognition and activation by innate immune receptor RIG-I | Nature | 2011 | 364 |
| 14 | Codon influence on protein expression in E. coli correlates with mRNA levels | Nature | 2016 | 350 |
| 15 | In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, Rilpivirine) | Journal of Medicinal Chemistry | 2005 | 326 |
| 16 | Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor | Nature | 1995 | 322 |
| 17 | The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. | Genes and Development | 1996 | 318 |
| 18 | End-joining, translocations and cancer | Nature Reviews Cancer | 2013 | 311 |
| 19 | High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 310 |
| 20 | Structures of influenza A proteins and insights into antiviral drug targets | Nature Structural and Molecular Biology | 2010 | 292 |
| 21 | Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime | Nature | 2002 | 285 |
| 22 | Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy | Cancer Cell | 2005 | 276 |
| 23 | Molecular Modeling and Biochemical Characterization Reveal the Mechanism of Hepatitis B Virus Polymerase Resistance to Lamivudine (3TC) and Emtricitabine (FTC) | Journal of Virology | 2001 | 263 |
| 24 | Resetting the Drosophila Clock by Photic Regulation of PER and a PER-TIM Complex | Science | 1996 | 260 |
| 25 | Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 | Nature | 2014 | 259 |
| 26 | Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 257 |
| 27 | Viral homologs of BCL-2: role of apoptosis in the regulation of virus infection | Genes and Development | 2002 | 253 |
| 28 | A role for CK2 in the Drosophila circadian oscillator | Nature Neuroscience | 2003 | 251 |
| 29 | Circadian rhythms in a nutshell | Physiological Genomics | 2000 | 245 |
| 30 | The RNA Polymerase “Switch Region” Is a Target for Inhibitors | Cell | 2008 | 234 |
| 31 | Partial NMR assignments for uniformly (13C, 15N)-enriched BPTI in the solid state | Journal of Biomolecular NMR | 2000 | 232 |
| 32 | Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells | Journal of Virology | 1994 | 232 |
| 33 | RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids | Rna | 1999 | 225 |
| 34 | PER and TIM Inhibit the DNA Binding Activity of a Drosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription | Molecular and Cellular Biology | 1999 | 220 |
| 35 | Solution NMR structure of the major cold shock protein (CspA) from Escherichia coli: identification of a binding epitope for DNA. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 219 |
| 36 | The Drosophila CLOCK Protein Undergoes Daily Rhythms in Abundance, Phosphorylation, and Interactions with the PER–TIM Complex | Neuron | 1998 | 215 |
| 37 | Essential role for p53-mediated transcription in E1A-induced apoptosis. | Genes and Development | 1995 | 214 |
| 38 | A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans | Nature | 1994 | 212 |
| 39 | Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors | Progress in Biophysics and Molecular Biology | 2005 | 210 |
| 40 | Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein | Molecular and Cellular Biology | 1995 | 206 |
| 41 | Association of Bax and Bak Homo-oligomers in Mitochondria | Journal of Biological Chemistry | 2003 | 202 |
| 42 | Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators | Molecular and Cellular Biology | 1998 | 201 |
| 43 | Metabolic catastrophe as a means to cancer cell death | Journal of Cell Science | 2007 | 200 |
| 44 | Insights into DNA Polymerization Mechanisms from Structure and Function Analysis of HIV-1 Reverse Transcriptase | Biochemistry | 1995 | 195 |
| 45 | unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion | Neuron | 1997 | 195 |
| 46 | Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K | Molecular and Cellular Biology | 1996 | 194 |
| 47 | Structural basis for suppression of a host antiviral response by influenza A virus | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 193 |
| 48 | Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 188 |
| 49 | Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins. | Molecular and Cellular Biology | 1993 | 187 |
| 50 | Protein NMR spectroscopy in structural genomics | Nature Structural Biology | 2000 | 186 |
