| # | Title | Journal | Year | Citations |
|---|
| 1 | Physiology and role of irisin in glucose homeostasis | Nature Reviews Endocrinology | 2017 | 403 |
| 2 | Oxidized Low Density Lipoprotein Inhibits Interleukin-12 Production in Lipopolysaccharide-activated Mouse Macrophages via Direct Interactions between Peroxisome Proliferator-activated Receptor-γ and Nuclear Factor-κB | Journal of Biological Chemistry | 2000 | 320 |
| 3 | Differential Regulation of the Dopamine D2and D3 Receptors by G Protein-coupled Receptor Kinases and β-Arrestins | Journal of Biological Chemistry | 2001 | 264 |
| 4 | Self-assembled nanoparticles of hydrophobically-modified polysaccharide bearing vitamin H as a targeted anti-cancer drug delivery system | European Journal of Pharmaceutical Sciences | 2003 | 224 |
| 5 | Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems | International Journal of Pharmaceutics | 2009 | 222 |
| 6 | Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations | Journal of Biological Chemistry | 1998 | 211 |
| 7 | Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits | Journal of Biological Chemistry | 1998 | 182 |
| 8 | The role of exercise-induced myokines in regulating metabolism | Archives of Pharmacal Research | 2018 | 175 |
| 9 | Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats | International Journal of Pharmaceutics | 2006 | 152 |
| 10 | Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2 | Nature Communications | 2015 | 142 |
| 11 | A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol | Angiogenesis | 1999 | 135 |
| 12 | Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza | Immunopharmacology | 2000 | 125 |
| 13 | Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-α, iNOS, and IL-12 production in LPS-stimulated macrophages | Life Sciences | 2003 | 124 |
| 14 | Studies of structure activity relationship of flavonoids for the anti-allergic actions | Archives of Pharmacal Research | 1998 | 120 |
| 15 | Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in murine macrophage cells | Archives of Pharmacal Research | 2003 | 112 |
| 16 | Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins | Structure | 2013 | 111 |
| 17 | Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal-regulated Kinase | Journal of Biological Chemistry | 2004 | 109 |
| 18 | A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis | Journal of Clinical Investigation | 2019 | 109 |
| 19 | Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages | British Journal of Pharmacology | 1999 | 105 |
| 20 | Synthesis, topoisomerase I inhibition and antitumor cytotoxicity of 2,2′:6′,2″-, 2,2′:6′,3″- and 2,2′:6′,4″-Terpyridine derivatives | Bioorganic and Medicinal Chemistry Letters | 2001 | 99 |
| 21 | Wnt-7a Causes Loss of Differentiated Phenotype and Inhibits Apoptosis of Articular Chondrocytes via Different Mechanisms | Journal of Biological Chemistry | 2004 | 99 |
| 22 | Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol, endocrine disruptors: involvement of nuclear factor-AT and Ca2+ | Immunology | 2003 | 89 |
| 23 | Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines | Bioorganic and Medicinal Chemistry | 2010 | 88 |
| 24 | Physicochemical characterization of solid dispersion of furosemide with TPGS | International Journal of Pharmaceutics | 2003 | 87 |
| 25 | Synthesis, topoisomerase I inhibition and structure–activity relationship study of 2,4,6-trisubstituted pyridine derivatives | Bioorganic and Medicinal Chemistry Letters | 2004 | 87 |
| 26 | Effects of non-ionic surfactants as permeation enhancers towards piroxicam from the poloxamer gel through rat skins | International Journal of Pharmaceutics | 2001 | 85 |
| 27 | Selectivity of commonly used inhibitors of clathrin-mediated and caveolae-dependent endocytosis of G protein–coupled receptors | Biochimica Et Biophysica Acta - Biomembranes | 2015 | 82 |
| 28 | G Protein-coupled Receptor Kinase Regulates Dopamine D3 Receptor Signaling by Modulating the Stability of a Receptor-Filamin-β-Arrestin Complex | Journal of Biological Chemistry | 2005 | 80 |
| 29 | Effects of resveratrol-related hydroxystilbenes on the nitric oxide production in macrophage cells: structural requirements and mechanism of action | Life Sciences | 2002 | 79 |
| 30 | Enhanced permeation of triamcinolone acetonide through the buccal mucosa | European Journal of Pharmaceutics and Biopharmaceutics | 2000 | 78 |
| 31 | Roles of Protein Kinase C and Actin-Binding Protein 280 in the Regulation of Intracellular Trafficking of Dopamine D3 Receptor | Molecular Endocrinology | 2007 | 75 |
| 32 | Bisphenol A-induced aromatase activation is mediated by cyclooxygenase-2 up-regulation in rat testicular Leydig cells | Toxicology Letters | 2010 | 75 |
| 33 | Current perspectives on the selective regulation of dopamine D2 and D3 receptors | Archives of Pharmacal Research | 2010 | 73 |
| 34 | Agonist-Induced Endocytosis and Receptor Phosphorylation Mediate Resensitization of Dopamine D2 Receptors | Molecular Endocrinology | 2010 | 72 |
| 35 | Long-term theranostic hydrogel system for solid tumors | Biomaterials | 2012 | 72 |
| 36 | Gender differences in pharmacokinetics and tissue distribution of 3 perfluoroalkyl and polyfluoroalkyl substances in rats | Food and Chemical Toxicology | 2016 | 72 |
| 37 | Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study | European Journal of Medicinal Chemistry | 2012 | 70 |
| 38 | 2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells | Chemico-Biological Interactions | 2013 | 70 |
| 39 | Effects of chitosan oligosaccharide (COS) on the glycerol-induced acute renal failure in vitro and in vivo | Food and Chemical Toxicology | 2008 | 68 |
| 40 | Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 68 |
| 41 | Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: Essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase | Toxicology and Applied Pharmacology | 2010 | 67 |
| 42 | Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells | Breast Cancer Research and Treatment | 2011 | 67 |
| 43 | Mucoadhesive and Physicochemical Characterization of Carbopol-Poloxamer Gels Containing Triamcinolone Acetonide | Drug Development and Industrial Pharmacy | 2000 | 66 |
| 44 | Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances | Oxidative Medicine and Cellular Longevity | 2020 | 66 |
| 45 | Effects of epigallocatechin gallate on the oral bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats | Anti-Cancer Drugs | 2009 | 65 |
| 46 | Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response | Immunology | 2003 | 64 |
| 47 | Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials | PLoS ONE | 2014 | 63 |
| 48 | Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs | Scientific Reports | 2017 | 63 |
| 49 | Enhanced efficacy by percutaneous absorption of piroxicam from the poloxamer gel in rats | International Journal of Pharmaceutics | 2000 | 61 |
| 50 | Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats | International Journal of Pharmaceutics | 2005 | 61 |
