| # | Title | Journal | Year | Citations |
|---|
| 1 | A Size Standard for Pharmacokinetics | Clinical Pharmacokinetics | 1996 | 424 |
| 2 | Human renal function maturation: a quantitative description using weight and postmenstrual age | Pediatric Nephrology | 2009 | 406 |
| 3 | Rat models of hypertension, cardiac hypertrophy and failure | Cardiovascular Research | 1998 | 404 |
| 4 | A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial | Journal of Allergy and Clinical Immunology | 2008 | 394 |
| 5 | A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models | Computer Methods and Programs in Biomedicine | 1999 | 318 |
| 6 | Clinical Pharmacokinetics of H1-Receptor Antagonists (The Antihistamines) | Clinical Pharmacokinetics | 1985 | 309 |
| 7 | The response to levodopa in parkinson's disease: Imposing pharmacological law and order | Annals of Neurology | 1996 | 296 |
| 8 | Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity | Nature Communications | 2017 | 265 |
| 9 | Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics | CPT: Pharmacometrics and Systems Pharmacology | 2017 | 261 |
| 10 | Brain Pericytes As Mediators of Neuroinflammation | Trends in Pharmacological Sciences | 2017 | 253 |
| 11 | Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases | Progress in Neurobiology | 2000 | 251 |
| 12 | Clinical Pharmacokinetics and Pharmacodynamics of Warfarin | Clinical Pharmacokinetics | 1986 | 249 |
| 13 | Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system | Progress in Neurobiology | 1999 | 247 |
| 14 | Clinical Pharmacokinetics of Ethanol | Clinical Pharmacokinetics | 1987 | 223 |
| 15 | Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists | Science Signaling | 2020 | 219 |
| 16 | The human side of microglia | Trends in Neurosciences | 2014 | 206 |
| 17 | The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial | Lancet Respiratory Medicine,the | 2015 | 189 |
| 18 | Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease | Neuroscience | 2004 | 186 |
| 19 | Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon‐γ and breast milk transforming growth factor‐β and immunoglobin A detection | Clinical and Experimental Allergy | 2008 | 185 |
| 20 | Size, Myths and the Clinical Pharmacokinetics of Analgesia in Paediatric Patients | Clinical Pharmacokinetics | 1997 | 180 |
| 21 | The role of inducible transcription factors in apoptotic nerve cell death | Brain Research Reviews | 1995 | 174 |
| 22 | In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake | Journal of Inorganic Biochemistry | 2008 | 174 |
| 23 | Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs | British Journal of Cancer | 2000 | 170 |
| 24 | Clinical Trial Simulation: A Review | Clinical Pharmacology and Therapeutics | 2010 | 169 |
| 25 | Independent Regulation of Apical and Basolateral Drug Transporter Expression and Function in Placental Trophoblasts by Cytokines, Steroids, and Growth Factors | Drug Metabolism and Disposition | 2007 | 165 |
| 26 | Population clinical pharmacology of children: modelling covariate effects | European Journal of Pediatrics | 2006 | 158 |
| 27 | Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates | Molecular Therapy | 2009 | 150 |
| 28 | AAV-Mediated gene delivery of BDNF or GDNF is neuroprotective in a model of huntington disease | Molecular Therapy | 2004 | 149 |
| 29 | Understanding dosing: children are small adults, neonates are immature children | Archives of Disease in Childhood | 2013 | 148 |
| 30 | Tips and traps analyzing pediatric PK data | Paediatric Anaesthesia | 2011 | 141 |
| 31 | Safety assessment of postoperative pain management by an acute pain service | Pain | 1993 | 139 |
| 32 | Progression of motor and nonmotor features of Parkinson's disease and their response to treatment | British Journal of Clinical Pharmacology | 2012 | 139 |
| 33 | Platinum neurotoxicity: clinical profiles, experimental models and neuroprotective approaches | Journal of Inorganic Biochemistry | 1999 | 138 |
| 34 | Disrupting established tumor blood vessels | Cancer | 2010 | 138 |
| 35 | TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function | Journal of Neuroinflammation | 2016 | 136 |
| 36 | Improving the oral bioavailability of beneficial polyphenols through designed synergies | Genes and Nutrition | 2010 | 134 |
| 37 | Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells | Journal of Neuroinflammation | 2015 | 134 |
| 38 | Adverse Effects of Systemic Opioid Analgesics | Drug Safety | 1992 | 132 |
| 39 | Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide | Brain Research | 2006 | 130 |
| 40 | The SLCO1B1 rs4149032 Polymorphism Is Highly Prevalent in South Africans and Is Associated with Reduced Rifampin Concentrations: Dosing Implications | Antimicrobial Agents and Chemotherapy | 2011 | 130 |
| 41 | Allopregnanolone regulates neurogenesis and depressive/anxiety-like behaviour in a social isolation rodent model of chronic stress | Neuropharmacology | 2012 | 130 |
| 42 | A role for human brain pericytes in neuroinflammation | Journal of Neuroinflammation | 2014 | 125 |
| 43 | The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain | Neuroscience | 2005 | 124 |
| 44 | The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair | Molecular Brain Research | 1996 | 123 |
| 45 | Loss of A1 adenosine receptors in human temporal lobe epilepsy | Brain Research | 1996 | 120 |
| 46 | Prostaglandins and parturition | Reproduction, Fertility and Development | 1995 | 115 |
| 47 | Structural and solution chemistry of gold(I) and silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agents | Coordination Chemistry Reviews | 1999 | 115 |
| 48 | Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal! | Journal of Neuroscience Methods | 2008 | 113 |
| 49 | Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons | Journal of Pharmacology and Experimental Therapeutics | 2011 | 112 |
| 50 | Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain | Neurobiology of Disease | 2015 | 112 |
