| # | Title | Journal | Year | Citations |
|---|
| 1 | The Role of Metallothionein in Oxidative Stress | International Journal of Molecular Sciences | 2013 | 632 |
| 2 | Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 | Chemico-Biological Interactions | 2002 | 487 |
| 3 | In vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity | Nature Biotechnology | 2015 | 362 |
| 4 | Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes | Cancer Research | 2002 | 200 |
| 5 | Comparison of hormonal responses to heat, drought and combined stress in tobacco plants with elevated proline content | Journal of Plant Physiology | 2010 | 183 |
| 6 | Functional Role of C-Terminal Cytoplasmic Tail of Rat Vanilloid Receptor 1 | Journal of Neuroscience | 2003 | 181 |
| 7 | What can enzymes of C4 photosynthesis do for C3 plants under stress? | Plant Science | 2011 | 173 |
| 8 | The role of cytokinins in responses to water deficit in tobacco plants over‐expressing trans‐zeatin O‐glucosyltransferase gene under 35S or SAG12 promoters | Plant, Cell and Environment | 2008 | 160 |
| 9 | Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment | Food and Chemical Toxicology | 2004 | 154 |
| 10 | Gaseous O2, NO, and CO in Signal Transduction: Structure and Function Relationships of Heme-Based Gas Sensors and Heme-Redox Sensors | Chemical Reviews | 2015 | 150 |
| 11 | Relevance of miR-21 and miR-143 expression in tissue samples of colorectal carcinoma and its liver metastases | Cancer Genetics and Cytogenetics | 2010 | 139 |
| 12 | The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts☆1☆Supported by German Cancer Research Center, Grant Agency of the Czech Republic (grant 203/01/0996) and the Ministry of Education of the Czech Republic (grant MSM 1131 00001).1Abbreviations: α-NF, α-naphthoflavone; 3-IPMDIA, 3-isopropenyl-3-methyldiamantane; CHAPS, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate; CYP, cytochrome P450; IC50, 50% inhibitory dose; MDR, multidrug resistance; PEI, polyethyle | Biochemical Pharmacology | 2001 | 138 |
| 13 | Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres | Chemical Society Reviews | 2019 | 138 |
| 14 | The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N2-Oxide | Cancer Research | 2004 | 125 |
| 15 | Antibacterial screening of some Peruvian medicinal plants used in Callería District | Journal of Ethnopharmacology | 2005 | 121 |
| 16 | Human Enzymes Involved in the Metabolic Activation of Carcinogenic Aristolochic Acids: Evidence for Reductive Activation by Cytochromes P450 1A1 and 1A2 | Chemical Research in Toxicology | 2001 | 120 |
| 17 | Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of atmospheric particulate matter from São Paulo, Brazil | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | 2008 | 116 |
| 18 | Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice | Carcinogenesis | 2007 | 115 |
| 19 | A biosensor for the detection of triazine and phenylurea herbicides designed using Photosystem II coupled to a screen-printed electrode | Biotechnology and Bioengineering | 2002 | 105 |
| 20 | Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy | Mutation Research - Reviews in Mutation Research | 2008 | 103 |
| 21 | Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase | Carcinogenesis | 2003 | 97 |
| 22 | Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures | Carcinogenesis | 1994 | 95 |
| 23 | Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers | Cancer Letters | 2005 | 95 |
| 24 | Effect of posttranslational modifications on enzyme function and assembly | Journal of Proteomics | 2013 | 93 |
| 25 | Sarcosine as a Potential Prostate Cancer Biomarker—A Review | International Journal of Molecular Sciences | 2013 | 93 |
| 26 | Effect of heavy metal ions on growth and biochemical characteristics of photosynthesis of barley and maize seedlings | Biologia Plantarum | 1987 | 90 |
| 27 | Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:Cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer | International Journal of Cancer | 2005 | 90 |
| 28 | Vertebrate metallothioneins as target molecules for analytical techniques | TrAC - Trends in Analytical Chemistry | 2010 | 90 |
| 29 | Is aristolochic acid a risk factor for Balkan endemic nephropathy‐associated urothelial cancer? | International Journal of Cancer | 2002 | 89 |
| 30 | Some potentialities and drawbacks of contemporary size-exclusion chromatography | Journal of Proteomics | 2003 | 86 |
| 31 | Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy | Carcinogenesis | 2002 | 85 |
| 32 | Design, functional evaluation and biomedical applications of carbohydrate dendrimers (glycodendrimers) | Reviews in Molecular Biotechnology | 2002 | 85 |
| 33 | Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein | Scientific Reports | 2016 | 81 |
| 34 | Structure of human α1-acid glycoprotein and its high-affinity binding site | Biochemical and Biophysical Research Communications | 2003 | 80 |
| 35 | Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy | International Journal of Cancer | 2014 | 80 |
| 36 | A sensitive photosystem II-based biosensor for detection of a class of herbicides | Biotechnology and Bioengineering | 1998 | 77 |
| 37 | Metallothioneins and zinc in cancer diagnosis and therapy | Drug Metabolism Reviews | 2012 | 77 |
| 38 | DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique | Chemico-Biological Interactions | 2002 | 76 |
| 39 | Purification and characterization of a nitrilase from Aspergillus niger K10 | Applied Microbiology and Biotechnology | 2006 | 76 |
| 40 | Decreased paraoxonase activity in critically ill patients with sepsis | Clinical and Experimental Medicine | 2010 | 75 |
| 41 | Phosphoenolpyruvate carboxylase, NADP-malic enzyme, and pyruvate, phosphate dikinase are involved in the acclimation of Nicotiana tabacum L. to drought stress | Journal of Plant Physiology | 2014 | 74 |
| 42 | Defining a lectin | Nature | 1981 | 71 |
| 43 | Heme-based Globin-coupled Oxygen Sensors: Linking Oxygen Binding to Functional Regulation of Diguanylate Cyclase, Histidine Kinase, and Methyl-accepting Chemotaxis | Journal of Biological Chemistry | 2013 | 71 |
| 44 | Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs nephropathy | Experimental and Toxicologic Pathology | 1999 | 69 |
| 45 | DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer | International Journal of Molecular Sciences | 2017 | 67 |
| 46 | DNA adduct formation by the anticancer drug ellipticine in rats determined by32P postlabeling | International Journal of Cancer | 2003 | 66 |
| 47 | Modern Micro and Nanoparticle-Based Imaging Techniques | Sensors | 2012 | 66 |
| 48 | Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase — 32P-postlabeling analysis of DNA adduct formation | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | 2001 | 65 |
| 49 | α5β1 integrin antagonists reduce chemotherapy‐induced premature senescence and facilitate apoptosis in human glioblastoma cells | International Journal of Cancer | 2010 | 65 |
| 50 | Ellipticine cytotoxicity to cancer cell lines - a comparative study | Interdisciplinary Toxicology | 2011 | 64 |
