| # | Title | Journal | Year | Citations |
|---|
| 1 | Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer | Nature Medicine | 2016 | 1,193 |
| 2 | Structure of calmodulin refined at 2.2 Å resolution | Journal of Molecular Biology | 1988 | 1,104 |
| 3 | EGF receptor | International Journal of Biochemistry and Cell Biology | 1999 | 882 |
| 4 | Intracellular cyclic GMP receptor proteins | FASEB Journal | 1993 | 612 |
| 5 | Mycoplasmas and Ureaplasmas as Neonatal Pathogens | Clinical Microbiology Reviews | 2005 | 504 |
| 6 | Modern Age Pathology of Pulmonary Arterial Hypertension | American Journal of Respiratory and Critical Care Medicine | 2012 | 501 |
| 7 | Regulation of Myosin Phosphatase by a Specific Interaction with cGMP- Dependent Protein Kinase I | Science | 1999 | 489 |
| 8 | Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143] | Journal of Cell Biology | 1993 | 446 |
| 9 | Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP | American Journal of Physiology - Cell Physiology | 1994 | 406 |
| 10 | A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 312 |
| 11 | Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes | Journal of Biological Chemistry | 2013 | 277 |
| 12 | Acute Interstitial Pneumonia | American Journal of Surgical Pathology | 1986 | 262 |
| 13 | PD-L1hi B cells are critical regulators of humoral immunity | Nature Communications | 2015 | 261 |
| 14 | Isolated Lymphoid Follicle Formation Is Inducible and Dependent Upon Lymphotoxin-Sufficient B Lymphocytes, Lymphotoxin β Receptor, and TNF Receptor I Function | Journal of Immunology | 2003 | 259 |
| 15 | Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation | Nature | 1993 | 253 |
| 16 | Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 Å resolution | EMBO Journal | 1997 | 233 |
| 17 | Liver-specific Deletion of the Growth Hormone Receptor Reveals Essential Role of Growth Hormone Signaling in Hepatic Lipid Metabolism | Journal of Biological Chemistry | 2009 | 230 |
| 18 | The Reaction between Nitrite and Deoxyhemoglobin | Journal of Biological Chemistry | 2005 | 229 |
| 19 | The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 219 |
| 20 | Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin | Nature Chemical Biology | 2007 | 206 |
| 21 | Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. | Journal of Biological Chemistry | 1994 | 199 |
| 22 | Focal adhesion kinase in netrin-1 signaling | Nature Neuroscience | 2004 | 196 |
| 23 | Loss of Fibroblast Thy-1 Expression Correlates with Lung Fibrogenesis | American Journal of Pathology | 2005 | 194 |
| 24 | Regulatory T Cell Suppression and Anergy Are Differentially Regulated by Proinflammatory Cytokines Produced by TLR-Activated Dendritic Cells | Journal of Immunology | 2004 | 192 |
| 25 | Skeletal Muscle Composition and Its Relation to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction | American Journal of Cardiology | 2014 | 183 |
| 26 | Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase | Journal of Biological Chemistry | 1994 | 183 |
| 27 | Development and Validation of a Fourfold Multiplexed Opsonization Assay (MOPA4) for Pneumococcal Antibodies | Vaccine Journal | 2006 | 173 |
| 28 | STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2) | | 1992 | 163 |
| 29 | Pathologic Features of Allergic Bronchopulmonary Aspergillosis | American Journal of Surgical Pathology | 1988 | 158 |
| 30 | Modification of the Mitochondrial Proteome in Response to the Stress of Ethanol-dependent Hepatotoxicity | Journal of Biological Chemistry | 2004 | 158 |
| 31 | Requirement of KISS1 Secretion for Multiple Organ Metastasis Suppression and Maintenance of Tumor Dormancy | Journal of the National Cancer Institute | 2007 | 155 |
| 32 | Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humans | Journal of Immunology | 1989 | 153 |
| 33 | Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44+CD25+Pro-T thymocytes | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 149 |
| 34 | Mesenchymal Stem Cells Expressing Osteogenic and Angiogenic Factors Synergistically Enhance Bone Formation in a Mouse Model of Segmental Bone Defect | Molecular Therapy | 2010 | 143 |
| 35 | Tissue localization and CD8 accessory molecule expression of T gamma delta cells in humans. | Journal of Immunology | 1989 | 141 |
| 36 | Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor | Journal of Molecular Biology | 1992 | 138 |
| 37 | LIM Kinase 1 Is Essential for the Invasive Growth of Prostate Epithelial Cells | Journal of Biological Chemistry | 2003 | 135 |
| 38 | A Prospective Evaluation of an Algorithm Incorporating Routine Preoperative Endoscopic Ultrasound-Guided Fine Needle Aspiration in Suspected Pancreatic Cancer | Journal of Gastrointestinal Surgery | 2007 | 124 |
| 39 | Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals | Immunity | 2013 | 124 |
| 40 | Glial injury in neurotoxicity after pediatric CD19‐directed chimeric antigen receptor T cell therapy | Annals of Neurology | 2019 | 124 |
| 41 | Xylazine spreads across the US: A growing component of the increasingly synthetic and polysubstance overdose crisis | Drug and Alcohol Dependence | 2022 | 113 |
| 42 | Possible Role of Phytohaemagglutinin in Phaseolus vulgaris L. | Nature: New Biology | 1973 | 112 |
| 43 | Effects of Chronicβ-Adrenergic Receptor Stimulation in Mice | Journal of Molecular and Cellular Cardiology | 1997 | 110 |
| 44 | Anti-HIV Activity in Cervical-Vaginal Secretions from HIV-Positive and -Negative Women Correlate with Innate Antimicrobial Levels and IgG Antibodies | PLoS ONE | 2010 | 109 |
| 45 | Notch2 Haploinsufficiency Results in Diminished B1 B Cells and a Severe Reduction in Marginal Zone B Cells | Journal of Immunology | 2003 | 108 |
| 46 | Heparan Sulfate Chains of Syndecan-1 Regulate Ectodomain Shedding | Journal of Biological Chemistry | 2012 | 104 |
| 47 | Endoscopic Ultrasound-Guided Fine-Needle Aspiration: A Cytopathologist's Perspective | American Journal of Clinical Pathology | 2003 | 104 |
| 48 | Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 102 |
| 49 | Increased ischemic injury but decreased hypoxic injury in hypertrophied rat hearts. | Circulation Research | 1990 | 97 |
| 50 | Keynote review: Recent advances in biomarkers for cancer diagnosis and treatment | Drug Discovery Today | 2005 | 97 |
