| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 8,001 |
| 2 | A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains | Nature Medicine | 2000 | 1,945 |
| 3 | Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial | Lancet, The | 2012 | 1,041 |
| 4 | Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial | Lancet, The | 2012 | 1,040 |
| 5 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 6 | Transcranial Magnetic Stimulation during Positron Emission Tomography: A New Method for Studying Connectivity of the Human Cerebral Cortex | Journal of Neuroscience | 1997 | 657 |
| 7 | Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway | | 2014 | 648 |
| 8 | Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy | Annals of Neurology | 2001 | 451 |
| 9 | Narcolepsy is strongly associated with the T-cell receptor alpha locus | Nature Genetics | 2009 | 445 |
| 10 | Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study | Lancet Neurology, The | 2009 | 430 |
| 11 | Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy | Nature Genetics | 2004 | 395 |
| 12 | Elevated Anti-Streptococcal Antibodies in Patients with Recent Narcolepsy Onset | Sleep | 2009 | 311 |
| 13 | Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease? | Nature Reviews Neurology | 2018 | 293 |
| 14 | Autologous Bone Marrow Transplantation in Patients with Subacute and Chronic Spinal Cord Injury | Cell Transplantation | 2006 | 292 |
| 15 | Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force | European Journal of Neurology | 2006 | 276 |
| 16 | Structure and Pathology of Tau Protein in Alzheimer Disease | International Journal of Alzheimer's Disease | 2012 | 276 |
| 17 | Spatial navigation deficit in amnestic mild cognitive impairment | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 258 |
| 18 | PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome | Nature Genetics | 2008 | 252 |
| 19 | Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study | Multiple Sclerosis Journal | 2015 | 249 |
| 20 | EFNS‐ENS Guidelines on the diagnosis and management of disorders associated with dementia | European Journal of Neurology | 2012 | 239 |
| 21 | EFNS guidelines on management of narcolepsy | European Journal of Neurology | 2006 | 235 |
| 22 | Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica | Journal of Neurology, Neurosurgery and Psychiatry | 2016 | 228 |
| 23 | Dose-Dependent Reduction of Cerebral Blood Flow During Rapid-Rate Transcranial Magnetic Stimulation of the Human Sensorimotor Cortex | Journal of Neurophysiology | 1998 | 224 |
| 24 | Pramipexole and pergolide in the treatment of depression in Parkinson's disease: a national multicentre prospective randomized study | European Journal of Neurology | 2003 | 220 |
| 25 | Risk stratification for progressive multifocal leukoencephalopathy in patients treated with natalizumab | Multiple Sclerosis Journal | 2012 | 220 |
| 26 | ImmunoChip Study Implicates Antigen Presentation to T Cells in Narcolepsy | PLoS Genetics | 2013 | 206 |
| 27 | Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis | JAMA Neurology | 2017 | 199 |
| 28 | The pressure measurement in the ulnar nerve. A contribution to the pathophysiology of the cubital tunnel syndrome | Journal of Biomechanics | 1975 | 166 |
| 29 | Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1 | PLoS Genetics | 2011 | 163 |
| 30 | Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study | Journal of Neurology | 2016 | 158 |
| 31 | Functional magnetic resonance imaging during deep brain stimulation: A pilot study in four patients with Parkinson's disease | Movement Disorders | 2001 | 153 |
| 32 | Decreased CSF Histamine in Narcolepsy With and Without Low CSF Hypocretin-1 in Comparison to Healthy Controls | Sleep | 2009 | 142 |
| 33 | Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores | Nature Communications | 2021 | 140 |
| 34 | Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study | JAMA Neurology | 2021 | 132 |
| 35 | European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society | European Journal of Neurology | 2012 | 131 |
| 36 | Selecting deep brain stimulation or infusion therapies in advanced Parkinson’s disease: an evidence-based review | Journal of Neurology | 2013 | 128 |
| 37 | Survey on cannabis use in Parkinson's disease: Subjective improvement of motor symptoms | Movement Disorders | 2004 | 127 |
| 38 | Evidence of a non-progressive course of alternating hemiplegia of childhood: study of a large cohort of children and adults | Brain | 2010 | 126 |
| 39 | Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study | Multiple Sclerosis Journal | 2017 | 126 |
| 40 | Transplantation of Mesenchymal Stromal Cells in Patients with Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial | Cell Transplantation | 2017 | 123 |
| 41 | Spatial navigation testing discriminates two types of amnestic mild cognitive impairment | Behavioural Brain Research | 2009 | 122 |
| 42 | Genetic predisposition in anti‐LGI1 and anti‐NMDA receptor encephalitis | Annals of Neurology | 2018 | 120 |
| 43 | Spectral analysis of the heart rate variability in sleep | Physiological Research | 2005 | 120 |
| 44 | Clinical Phenotypes and Comorbidity in European Sleep Apnoea Patients | PLoS ONE | 2016 | 118 |
| 45 | Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhood—a study of 155 patients | Orphanet Journal of Rare Diseases | 2015 | 117 |
| 46 | REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy | Sleep Medicine | 2007 | 115 |
| 47 | Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome | Brain | 2018 | 115 |
| 48 | Long‐term follow‐up of Wilson Disease: natural history, treatment, mutations analysis and phenotypic correlation | Liver International | 2011 | 114 |
| 49 | Anti-Tribbles Homolog 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy | Sleep | 2010 | 113 |
| 50 | Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: An open label trial | Brain Stimulation | 2013 | 113 |
