| # | Title | Journal | Year | Citations |
|---|
| 1 | Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study | Scientific Reports | 2021 | 9,439 |
| 2 | Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria | Annals of Neurology | 2011 | 8,001 |
| 3 | EAU Guidelines on Non–Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016 | European Urology | 2017 | 1,594 |
| 4 | Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial | Lancet, The | 2019 | 1,274 |
| 5 | ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging | Bioinformatics | 2014 | 1,252 |
| 6 | EAU Guidelines on Interventional Treatment for Urolithiasis | European Urology | 2016 | 1,166 |
| 7 | Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours | Journal of Pathology | 2014 | 1,151 |
| 8 | 2016 updated EULAR evidence-based recommendations for the management of gout | Annals of the Rheumatic Diseases | 2017 | 1,096 |
| 9 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 10 | European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (TaT1 and Carcinoma In Situ) - 2019 Update | European Urology | 2019 | 936 |
| 11 | ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma | International Journal of Gynecological Cancer | 2021 | 859 |
| 12 | Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases | European Heart Journal | 2016 | 757 |
| 13 | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa | Nature Genetics | 2019 | 641 |
| 14 | EAU Guidelines on Non-Muscle-Invasive Urothelial Carcinoma of the Bladder | European Urology | 2008 | 592 |
| 15 | The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation | Atherosclerosis | 2015 | 587 |
| 16 | EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis | European Urology | 2016 | 581 |
| 17 | Performance measures for lower gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative | Endoscopy | 2017 | 533 |
| 18 | Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 | Nature | 2017 | 516 |
| 19 | Lung cancer susceptibility locus at 5p15.33 | Nature Genetics | 2008 | 514 |
| 20 | The Beaker phenomenon and the genomic transformation of northwest Europe | Nature | 2018 | 503 |
| 21 | The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis | American Journal of Psychiatry | 2018 | 476 |
| 22 | Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases | European Heart Journal | 2021 | 434 |
| 23 | Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study | Lancet Neurology, The | 2009 | 430 |
| 24 | The role of adipose tissue immune cells in obesity and low-grade inflammation | Journal of Endocrinology | 2014 | 409 |
| 25 | Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study | Blood | 2009 | 383 |
| 26 | Durvalumab, with or without tremelimumab, plus platinum–etoposide versus platinum–etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial | Lancet Oncology, The | 2021 | 356 |
| 27 | Hypersensitivity Pneumonitis: Perspectives in Diagnosis and Management | American Journal of Respiratory and Critical Care Medicine | 2017 | 338 |
| 28 | Déjà vu in proteomics. A hit parade of repeatedly identified differentially expressed proteins | Proteomics | 2008 | 337 |
| 29 | 137 ancient human genomes from across the Eurasian steppes | Nature | 2018 | 325 |
| 30 | Cardiac manifestations of Anderson-Fabry disease: results from the international Fabry outcome survey | European Heart Journal | 2007 | 320 |
| 31 | Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals | European Journal of Clinical Pharmacology | 2011 | 284 |
| 32 | Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus | Physiological Research | 2002 | 284 |
| 33 | Angiogenic factors are elevated in overweight and obese individuals | International Journal of Obesity | 2005 | 278 |
| 34 | Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data | Lancet Oncology, The | 2015 | 277 |
| 35 | Oxidative stress, metabolism of ethanol and alcohol-related diseases | Journal of Biomedical Science | 2001 | 273 |
| 36 | Determinants of Procedural Pain Intensity in the Intensive Care Unit. The Europain® Study | American Journal of Respiratory and Critical Care Medicine | 2014 | 259 |
| 37 | Cell biology of hydrogels | Biomaterials | 1993 | 251 |
| 38 | Polypharmacy in Nursing Home in Europe: Results From the SHELTER Study | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2012 | 250 |
| 39 | Cystathionine ?-synthase mutations in homocystinuria | | 1999 | 247 |
| 40 | Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis | Nature Communications | 2017 | 245 |
| 41 | Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing | Nature Genetics | 2013 | 237 |
| 42 | Mutations in DNAJC5, Encoding Cysteine-String Protein Alpha, Cause Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis | American Journal of Human Genetics | 2011 | 236 |
| 43 | Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica | Journal of Neurology, Neurosurgery and Psychiatry | 2016 | 228 |
| 44 | Late-Onset Wilson’s Disease | Gastroenterology | 2007 | 227 |
| 45 | The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases | Frontiers in Pharmacology | 2012 | 224 |
| 46 | Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3 | Nature Genetics | 2011 | 220 |
| 47 | Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study | Lancet Neurology, The | 2020 | 219 |
| 48 | Prevalence of primary hyperaldosteronism in moderate to severe hypertension in the Central Europe region | Journal of Human Hypertension | 2003 | 213 |
| 49 | Core/Shell Nanofibers with Embedded Liposomes as a Drug Delivery System | Biomacromolecules | 2012 | 212 |
| 50 | EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis | Annals of the Rheumatic Diseases | 2017 | 209 |
