920(top 1%)
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Top Articles

#TitleJournalYearCitations
1Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamineNeuropharmacology19861,247
2Airway Smooth Muscle Cell Proliferation Is Increased in AsthmaAmerican Journal of Respiratory and Critical Care Medicine2001475
3How opioids inhibit GABA-mediated neurotransmissionNature1997468
4THE 'ABC' OF GABA RECEPTORS: A BRIEF REVIEWClinical and Experimental Pharmacology and Physiology1999347
5GABA-Activated Ligand Gated Ion Channels:  Medicinal Chemistry and Molecular BiologyJournal of Medicinal Chemistry2000326
6Parkinson's disease, pesticides, and glutathione transferase polymorphismsLancet, The1998303
7GABAA receptor pharmacologyLancet, The1996292
8Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following ExposureNeuropsychopharmacology2008271
9Interaction between glucocorticoids and β 2 agonists on bronchial airway smooth muscle cells through synchronised cellular signallingLancet, The2002261
10Dysfunctional Interaction of C/EBPα and the Glucocorticoid Receptor in Asthmatic Bronchial Smooth-Muscle CellsNew England Journal of Medicine2004254
11Footshock induced analgesia in mice: Its reversal by naloxone and cross tolerance with morphineLife Sciences1977240
12GABAA Receptor Channel PharmacologyCurrent Pharmaceutical Design2005240
13DPA-714, a New Translocator Protein–Specific Ligand: Synthesis, Radiofluorination, and Pharmacologic CharacterizationJournal of Nuclear Medicine2008237
14Increase by the ORL1 receptor (opioid receptor‐like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neuronesBritish Journal of Pharmacology1996215
15Central nervous system depressant action of flavonoid glycosidesEuropean Journal of Pharmacology2006215
162-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptorsNeuroscience Letters1988212
17OPIOID RECEPTOR SIGNALLING MECHANISMSClinical and Experimental Pharmacology and Physiology1999207
18Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitroBritish Journal of Pharmacology1996206
19Inflammatory response: an unrecognised source of variability in the pharmacokinetics and pharmacodynamics of cancer chemotherapyLancet Oncology, The2003205
20Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro.Journal of Physiology1997203
21Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase responseBritish Journal of Cancer2002198
22Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridgeNature Structural Biology2000194
23Flavonoid modulation of GABAA receptorsBritish Journal of Pharmacology2011192
24Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanismJournal of Allergy and Clinical Immunology2004191
25Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitroMolecular Pharmacology2000188
26Anatomy and electrophysiology of fast central synapses lead to a structural model for long-term potentiationPhysiological Reviews1995175
27Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of ratsBrain Research1989172
28The structure of a novel insecticidal neurotoxin, ω-atracotoxin-HV1, from the venom of an Australian funnel web spiderNature Structural Biology1997172
29Gingerols: a novel class of vanilloid receptor (VR1) agonistsBritish Journal of Pharmacology2002171
30(+)- And (−)-borneol: efficacious positive modulators of GABA action at human recombinant α1β2γ2L GABAA receptorsBiochemical Pharmacology2005170
31Actions of the ORL1Receptor Ligand Nociceptin on Membrane Properties of Rat Periaqueductal Gray NeuronsIn VitroJournal of Neuroscience1997168
32Diazepam enhancement of low affinity GABA binding to rat brain membranesNeuroscience Letters1982166
33Enhanced Opioid Efficacy in Opioid Dependence Is Caused by an Altered Signal Transduction PathwayJournal of Neuroscience1998150
34The Production of Extracellular Matrix Proteins by Human Passively Sensitized Airway Smooth-Muscle Cells in CultureAmerican Journal of Respiratory and Critical Care Medicine2000150
35Exhalation of respiratory viruses by breathing, coughing, and talkingJournal of Medical Virology2009147
36Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus In vitroJournal of Physiology2002146
37Drug combinations and impaired renal function - the 'triple whammy'British Journal of Clinical Pharmacology2005146
38Opioid Agonists Have Different Efficacy Profiles for G Protein Activation, Rapid Desensitization, and Endocytosis of Mu-opioid ReceptorsJournal of Biological Chemistry2003142
39The Hepatic Sinusoid in Aging and CirrhosisClinical Pharmacokinetics2005140
40ATP - a fast neurotransmitterFEBS Letters1993137
41Localization of 3 H‐Dihydroergotamine‐binding sites in the cat central nervous system: Relevance to migraineAnnals of Neurology1991135
42CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftmentLeukemia2007135
43The dietary flavonoids apigenin and (−)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABAA receptorsBiochemical Pharmacology2004129
44Cannabinoid receptor activation inhibits GABAergic neurotransmission in rostral ventromedial medulla neurons in vitroBritish Journal of Pharmacology1999124
45Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in RatsPLoS ONE2011123
46Where is the locus in opioid withdrawal?Trends in Pharmacological Sciences1997122
47DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implicationsTrends in Pharmacological Sciences2015122
48Expression of Connective Tissue Growth Factor in Asthmatic Airway Smooth Muscle CellsAmerican Journal of Respiratory and Critical Care Medicine2003120
49Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro.Journal of Physiology1996118
50Extracellular Matrix Regulates Enhanced Eotaxin Expression in Asthmatic Airway Smooth Muscle CellsAmerican Journal of Respiratory and Critical Care Medicine2006118