| # | Title | Journal | Year | Citations |
|---|
| 1 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 2 | A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease | Cell | 2017 | 3,282 |
| 3 | Network motifs: theory and experimental approaches | Nature Reviews Genetics | 2007 | 2,789 |
| 4 | Network motifs in the transcriptional regulation network of Escherichia coli | Nature Genetics | 2002 | 2,603 |
| 5 | Personalized Nutrition by Prediction of Glycemic Responses | Cell | 2015 | 1,816 |
| 6 | Cellular Senescence: Defining a Path Forward | Cell | 2019 | 1,551 |
| 7 | An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma | Cell | 2019 | 1,408 |
| 8 | UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development | Nature | 2007 | 1,183 |
| 9 | The human tumor microbiome is composed of tumor type–specific intracellular bacteria | Science | 2020 | 1,077 |
| 10 | The DNA-encoded nucleosome organization of a eukaryotic genome | Nature | 2009 | 1,063 |
| 11 | Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine | Science | 2017 | 1,059 |
| 12 | Functional atlas of the integrin adhesome | Nature Cell Biology | 2007 | 1,033 |
| 13 | Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features | Cell | 2018 | 1,015 |
| 14 | When mutants gain new powers: news from the mutant p53 field | Nature Reviews Cancer | 2009 | 999 |
| 15 | Decision making by p53: life, death and cancer | Cell Death and Differentiation | 2003 | 992 |
| 16 | A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor | Molecular and Cellular Biology | 1996 | 919 |
| 17 | Dynamics of the p53-Mdm2 feedback loop in individual cells | Nature Genetics | 2004 | 900 |
| 18 | Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning | Cell | 2013 | 898 |
| 19 | Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes | Cell | 2019 | 830 |
| 20 | Single-cell spatial reconstruction reveals global division of labour in the mammalian liver | Nature | 2017 | 809 |
| 21 | Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT | Cell | 2018 | 752 |
| 22 | Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis | Genes and Cancer | 2011 | 751 |
| 23 | Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling | Cell | 2015 | 728 |
| 24 | Outcome signature genes in breast cancer: is there a unique set? | Bioinformatics | 2005 | 721 |
| 25 | A histone H3 lysine 27 demethylase regulates animal posterior development | Nature | 2007 | 718 |
| 26 | The pros, cons, and many unknowns of probiotics | Nature Medicine | 2019 | 706 |
| 27 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers | Cell | 2020 | 691 |
| 28 | A comprehensive library of fluorescent transcriptional reporters for Escherichia coli | Nature Methods | 2006 | 680 |
| 29 | Negative Autoregulation Speeds the Response Times of Transcription Networks | Journal of Molecular Biology | 2002 | 672 |
| 30 | Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. | EMBO Journal | 1996 | 671 |
| 31 | The p53–Mdm2 module and the ubiquitin system | Seminars in Cancer Biology | 2003 | 665 |
| 32 | Binding and modulation of p53 by p300/CBP coactivators | Nature | 1997 | 664 |
| 33 | ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation | Molecular Cell | 2002 | 657 |
| 34 | Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes | Cell Death and Differentiation | 2009 | 599 |
| 35 | Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection | Science | 2018 | 582 |
| 36 | Biological Networks: The Tinkerer as an Engineer | Science | 2003 | 571 |
| 37 | Identification and consequences of miRNA–target interactions — beyond repression of gene expression | Nature Reviews Genetics | 2014 | 556 |
| 38 | ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage | Genes and Development | 2001 | 550 |
| 39 | Oscillations and variability in the p53 system | Molecular Systems Biology | 2006 | 539 |
| 40 | Dynamic Proteomics of Individual Cancer Cells in Response to a Drug | Science | 2008 | 539 |
| 41 | The Coherent Feedforward Loop Serves as a Sign-sensitive Delay Element in Transcription Networks | Journal of Molecular Biology | 2003 | 527 |
| 42 | Variability and memory of protein levels in human cells | Nature | 2006 | 526 |
| 43 | The integrin adhesome: from genes and proteins to human disease | Nature Reviews Molecular Cell Biology | 2014 | 526 |
| 44 | Evolutionary Trade-Offs, Pareto Optimality, and the Geometry of Phenotype Space | Science | 2012 | 516 |
| 45 | Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome | Cancer Research | 2000 | 508 |
| 46 | The microbiome and human cancer | Science | 2021 | 506 |
| 47 | Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy | Nature | 2011 | 502 |
| 48 | The extracellular matrix protein agrin promotes heart regeneration in mice | Nature | 2017 | 498 |
| 49 | Assigning numbers to the arrows: Parameterizing a gene regulation network by using accurate expression kinetics | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 479 |
| 50 | Hierarchical assembly of cell–matrix adhesion complexes | Biochemical Society Transactions | 2004 | 474 |
